| Interacting proteins: Q05682 and P29353 |
Pubmed |
SVM Score :0.0 |
| This complex consists of Src homologous collagen protein ( Shc ) , growth factor receptor binding protein 2 ( Grb 2 ) , son of sevenless ( Sos ) , and a novel tyrosine phosphorylated form of the cytoskeletal regulatory protein caldesmon . ^^^ Immunofluorescence localization studies further reveal that , in contrast to the distribution of caldesmon along actin stress fibers in normal fibroblasts , caldesmon colocalizes with Shc in plasma membrane blebs in transformed fibroblasts . ^^^ This colocalization of caldesmon and Shc correlates with actin stress fiber disassembly and 5 erbB mediated transformation . ^^^ The tyrosine phosphorylation of caldesmon , and its association with the Shc Grb 2 Sos signaling complex directly links tyrosine kinase oncogenic signaling events with cytoskeletal regulatory processes , and may define one mechanism regulating actin stress fiber disassembly in transformed cells . . ^^^ |
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| Interacting proteins: Q05682 and P29353 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of caldesmon is required for binding to the Shc . ^^^ |
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| Interacting proteins: Q05682 and P29353 |
Pubmed |
SVM Score :0.0 |
| This phosphoprotein complex includes Grb 2 , Shc , Sos , tyrosine phosphorylated form of caldesmon , and two , as yet , unidentified proteins . ^^^ |
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| Interacting proteins: Q05682 and P29353 |
Pubmed |
SVM Score :0.0 |
| The components of this signaling complex include the signal adapter proteins Shc , Grb 2 , and Nck , and tyrosine phosphorylated forms of p 21 activated kinase ( Pak ) , caldesmon , and myosin light chain kinase . ^^^ |
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