| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| This included treatment of cells with cAMP analogs , inclusion of phosphatase inhibitors or purified PKA in the pipette filling solution , co expression of catalytically active PKA , expression of the NR 1 PKA site phosphorylation site mimic ( S897D ) or by co expression of the PKA scaffolding protein yotiao or the dopamine D ( 1 ) receptor . ^^^ |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Yotiao , a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR 1 . ^^^ The yeast two hybrid screen was used here to identify yotiao , a novel coiled coil protein that interacts with NR 1 in a C 1 exon dependent manner . ^^^ With regard to immunohistochemistry , two anti yotiao antibodies display a somatodendritic staining pattern similar to each other and to the staining pattern of NR 1 . ^^^ Yotiao was colocalized by double label immunocytochemistry with NR 1 in rat brain and could be coimmunoprecipitated with NR 1 from heterologous cells . ^^^ Thus yotiao is an NR 1 binding protein potentially involved in cytoskeletal attachment of NMDA receptors . ^^^ |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Yotiao interacts with the NR 1 subunit of the NMDA receptor . ^^^ A stable complex composed of Yotiao , RII and NR 1 was immunoprecipitated from whole rat brain extracts . ^^^ Immunostaining analysis disclosed that Yotiao , RIIbeta and NR 1 colocalize in striatal and cerebellar neurons . ^^^ Co assembly of Yotiao / PKAII complexes with NR 1 subunits may promote cAMP dependent modulation of NMDA receptor activity at synapses , thereby influencing brain development and synaptic plasticity . . ^^^ |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The WDR 9 protein has a high similarity with the Mus musculus neuronal differentiation protein ( NDRP ) and a region of similarity with the region of the Yotiao protein that has been proposed to bind the NR 1 subunit of the NMDA receptor . ^^^ |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated dopamine glutamate interactions by measuring the expression of transcripts encoding the subunits for the ionotropic glutamate receptors ( NMDA , AMPA and kainate ) and five NMDAR associated intracellular proteins , PSD 93 , PSD 95 , SAP 102 , NF L and yotiao in the dopaminergic neurons in the substantia nigra pars compacta ( SNc ) of subjects with schizophrenia and a comparison group . ^^^ |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99996 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
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