| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.78840782 |
| Here we show that CaMKII directly binds to the NMDA receptor subunits NR 1 and NR2B . 0.78840782^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.55863154 |
| Like Ca ( 2+ ) / calmodulin , autophosphorylated CaMKII competes with alpha actinin 2 for binding to NR 1 . 0.55863154^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| SMI 34 labeling of perikarya and dendrites was prevented by pretreatment with either the NMDA receptor antagonist APV or by the Ca2+ / calmodulin dependent protein kinase ( CaMK ) inhibitor KN 62 , but not by antagonists of AMPA / kainate or metabotropic glutamate receptors or by inhibitors of arachidonic acid metabolic pathways . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We report here that haloperidol causes an increase in the activity of CaMK 2 and a decrease in the density of immuno gold labelling for glutamate within the nerve terminals of asymmetrical synapses containing a perforated or nonperforated PSD . ^^^ These results are consistent with the hypothesis that the haloperidol induced increase in activity of CaMK 2 and the increase in glutamate release , as suggested by the decrease in presynaptic glutamate immunoreactivity , may ultimately lead to an increase in the number of synapses displaying a perforated PSD . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We have examined glutamate receptors ( GluRs ) as substrates for CaM K 2 because ( 1 ) they are colocalized in the PSD , ( 2 ) cloned GluRs contain consensus phosphorylation sites for protein kinases including CaM K 2 , and ( 3 ) several GluRs are regulated by other protein kinases . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In contrast , neither CaM K 2 nor PKA seems to mediate the metabotropic glutamate receptor action on IAHP . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| This selectively solubilized actin and spectrin while other prominent PSD proteins , such as CaMK 2 alpha , the AMPA and NMDA type glutamate receptors and GABA receptors , were not extracted at all . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Ca2+ / calmodulin dependent protein kinase 2 ( CAMK 2 ) and one of its target , alpha amino 3 hydroxy 5 methylisoxazole 4 propionic acid ( AMPA ) , glutamate receptors have been shown to participate in both long term potentiation ( LTP ) in the hippocampus , and in spatial , as well as in a variety , of learning paradigms . ^^^ Taken together , these findings confirm and extend previous data suggesting that CAMK 2 and AMPA glutamate receptors in the hippocampus participate in the early phase of memory formation of an inhibitory avoidance learning . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Interestingly , KN 62 , which interferes with calcium calmodulin kinase ( CaM K ) activity , leads to a reduction of glutamate induced ERK activation and of CREB phosphorylation . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that CREB phosphorylation in neurons after ischemia and exposure to glutamate is induced by NMDA receptor gated calcium influx and subsequent activation of CaMK 2 4 and that CREB phosphorylation after metabolic stress might show a neuroprotective response through CRE mediated gene induction . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| A chronic ( 2 wk ) inactivation of N methyl D aspartate ( NMDA ) ionotropic glutamate receptors , L type voltage gated Ca ( 2+ ) channels , calmodulin , Ca ( 2+ ) / calmodulin dependent protein kinases II / IV ( CaMK II / IV ) , or protein kinase C ( PKC ) increased the number of cholinergic neurons ( to 15 24 % ) and induced ACh activity ( in 40 60 % of cells ) . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| A series of genes that were not reported before were up regulated by phenylalanine , including Ca ( 2+ ) / calmodulin dependent protein kinase , Brain type 2 ( CaMK 2 ) , Ras , P 38 MAP kinase , L voltage dependent calcium channel , some genes related to vesicle formation and transmitter release , some glutamate receptor subunits and glutamate transporters . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| These results indicate that activation of glutamate receptors triggers the release of purines from retinal cells by a mechanism involving calcium influx , CAMK 2 and the nitrobenzylthioinosine sensitive nucleoside transporter . ^^^ The regulation of adenosine release by glutamate receptors and CAMK 2 could have important consequences in the presynaptic control of glutamate release . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In experiment 1 , Western immunoblotting was used to demonstrate that i . c . v . injection of SKF 82958 ( 20 microg ) produces greater phosphorylation of the NMDA NR 1 subunit and calcium calmodulin kinase 2 ( CaMK 2 ) in NAc of FR as compared with AL rats . ^^^ These results point to specific neuroadaptations in the NAc of FR rats whereby D 1 DA receptor stimulation leads to increased NMDA NR 1 subunit phosphorylation and consequent increases in NMDA receptor dependent CaMK 2 and ERK1 / 2 signaling , and increased NMDA receptor / ERK1 / 2 dependent phosphorylation of the nuclear transcription factor , CREB . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| A series of genes that were not reported previously were upregulated by phenylalanine , including Ca2+ / calmodulin dependent protein kinase , Brain type 2 ( CaMK 2 ) , ras , P 38 , L voltage dependent calcium channel , some genes related to vesicle formation and transmitter release , some glutamate receptor subunits and glutamate transporters . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Purified PKC 2 and endogenous CaMK 2 catalyzed the phosphorylation of 80 200 kDa proteins in the PSD and L glutamate ( or NMDA ) induced increase of ( + ) 5 [ 3H ] methyl 10 , 11 dihydro 5H dibenzo [ a , d ] cyclohepten 5 , 10 imi ne maleate ( [ 3H ] MK 801 ; open channel blocker for NMDA receptor / channel ) binding activity was significantly enhanced . ^^^ However , the pretreatment of PKC 2 and CaMK 2 catalyzed phosphorylation did not change the binding activity of L [ 3H ] glutamate , cis 4 [ 3H ] ( phosphonomethyl ) piperidine 2 carboxylate ( [ 3H ] CGS 19755 ; competitive NMDA receptor antagonist ) , [ 3H ] glycine , alpha [ 3H ] amino 3 hydroxy 5 methyl isoxazole 4 propionate , or [ 3H ] kainate in the PSD . ^^^ Pretreatment with PKC 2 and CaMK 2 catalyzed phosphorylation enhanced L glutamate induced increase of [ 3H ] MK 801 binding additionally , although purified cyclic AMP dependent protein kinase did not change L glutamate induced [ 3H ] MK 801 binding . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The role of several biological molecules in learning and memory are considered , for example , protein kinase C ( PKC ) , Ca ( ++ ) Calmodulin kinase 2 ( CaMKII ) , GAP 43 , and glutamate receptors . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| To study potential molecular mechanisms of epileptogenesis in the neocortex , the motor cortex of rats was injected with tetanus toxin ( TT ) , and gene expression for 67 kDa glutamic acid decarboxylase ( GAD 67 ) , type 2 calcium / calmodulin dependent protein kinase ( CaMKII ) , NMDA receptor subunit 1 ( NR 1 ) , and AMPA receptor subunit 2 ( GluR 2 ) was investigated by in situ hybridization histochemistry . ^^^ Epileptic rats perfused 14 d after TT injection showed a focus of increased GAD 67 and NR 1 , and of decreased alpha CaMKII and GluR 2 mRNA levels at the injection site . ^^^ A zone of cortex surrounding the focus showed changes in alpha CaMKII , GAD 67 , and NR 1 mRNA levels that were reciprocal to those in the focus . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here we show that calcium independent CaMKII specifically binds to isolated postsynaptic densities ( PSDs ) , leading to enhanced phosphorylation of many PSD proteins including the alpha amino 3 hydroxy 5 methyl 4 isoxazole propionic acid ( AMPA ) type glutamate receptor . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Regulatory phosphorylation of AMPA type glutamate receptors by CaM KII during long term potentiation . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Preactivated recombinant alpha calcium calmodulin dependent multifunctional protein kinase 2 ( CaMKII * ) was perfused internally into CA 1 hippocampal slice neurons to test the effect on synaptic transmission and responses to exogenous application of glutamate analogues . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Ca2+ / CaM dependent protein kinase 2 ( CaM KII ) can phosphorylate and potentiate responses of alpha amino 3 hydroxyl 5 methyl 4 isoxazole propionate type glutamate receptors in a number of systems , and recent studies implicate this mechanism in long term potentiation , a cellular model of learning and memory . ^^^ In this study we have identified this CaM KII regulatory site using deletion and site specific mutants of glutamate receptor 1 ( GluR 1 ) . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| To examine in vivo the implication of CaMKII activity in synaptic plasticity , we used an animal model characterized by developmentally induced targeted neuronal ablation within the cortex and the hippocampus , and showing , at presynaptic level , molecular alterations leading to facilitation of glutamate release in hippocampal synapses ( methylazoxymethanol treated rats , MAM rats ) . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| LTP in the CA 1 field of the hippocampus requires activation of Ca2+ / calmodulin kinase 2 ( CaM KII ) , which phosphorylates Ser 831 in the GluR 1 subunit of the alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate glutamate receptor ( AMPA R ) , and this activation / phosphorylation is thought to be a postsynaptic mechanism in LTP . ^^^ Coexpression in HEK 293 cells of activated CaM KII with GluR 1 did not affect the glutamate affinity of the receptor , the kinetics of desensitization and recovery , channel rectification , open probability , or gating . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of the glutamate receptor 1 ( GluR 1 ) subunit of AMPA receptors by protein kinase A ( PKA ) , protein kinase C ( PKC ) , and Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) has been characterized extensively . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization histochemistry and immunocytochemistry were used to map distributions of cells expressing mRNAs encoding alpha , beta , gamma , and delta isoforms of type 2 calcium / calmodulin dependent protein kinase ( CaMKII ) , alpha amino 3 hydroxy 5 methyl 4 isoxazoleproprionate ( AMPA ) / kainate receptor subunits , ( GluR 1 7 ) , and N methyl D aspartate ( NMDA ) receptor subunits , NR 1 and NR2A D , or stained by subunit specific immunocytochemistry in the dorsal lateral geniculate nuclei of macaque monkeys . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Activation and Thr 286 autophosphorylation of calcium / calmodulindependent kinase 2 ( CaMKII ) following Ca2+ influx via N methyl D aspartate ( NMDA ) type glutamate receptors is essential for hippocampal long term potentiation ( LTP ) , a widely investigated cellular model of learning and memory . ^^^ Here , we show that NR2B , but not NR2A or NR 1 , subunits of NMDA receptors are responsible for autophosphorylation dependent targeting of CaMKII . ^^^ Autophosphorylation induces direct high affinity binding of CaMKII to a 50 amino acid domain in the NR2B cytoplasmic tail ; little or no binding is observed to NR2A and NR 1 cytoplasmic tails . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Ca2+ / calmodulin dependent protein kinase 2 ( CaM KII ) regulates numerous physiological functions , including neuronal synaptic plasticity through the phosphorylation of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid type glutamate receptors . ^^^ In COS 7 cells phosphorylation of transfected alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid type glutamate receptors by CaM KII , but not by protein kinase C , was blocked upon cotransfection with CaM KIIN . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The association of NMDA receptor subunits and CaMKII was assessed by immunoprecipitating PSD proteins with antibodies specific for NR2A / B and CaMKII : CaMKII coprecipitated with NR2A / B and NR 1 but not with other glutamate ionotropic receptor subunits , such as GluR 1 and GluR 2 3 . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that multifunctional calcium / calmodulin dependent protein kinase 2 ( CaMKII ) and one of its substrates , the glutamate receptor , are key players in experience driven synaptic plasticity in several areas of the central nervous system ( CNS ) . ^^^ To determine if CaMKII and the glutamate receptor are regulated by visual activity in the retina , we compared dark reared ( DR ; 1 week ) rats with control rats raised in a diurnal light dark cycle ( LD ) , at the following ages : postnatal day 12 ( P12d ) , 2 month ( 2m ) and 6 month ( 6m ) old . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In the CA 1 region , induction of LTP enhances the function of postsynaptic alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate receptors ( AMPARs ) because of the Ca2+ calmodulin kinase 2 ( CaMKII ) dependent phosphorylation of this subtype of glutamate receptor . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The level of antibody binding to the CamKII and the activity of CamKII were found to be increased after intravitreal injection of glutamate . ^^^ The glutamate mediated increases in CamKII were specific and blocked by 3 , 5 Dimethyl 1 adamantanamine ; 3 , 5 Dimethylamantadine ( Memantine ) , ( + / ) 2 Amino 5 Phosphopentonic ( AP 5 ) and 6 Cyano 7 Nitroquinoxaline 2 , 3 Dione ( CNQX ) but not with dl 2 Amino 3 Phosphono Propionic ( AP 3 ) . ^^^ The results indicate that the retinal neurotransmitter , glutamate , can regulate retinal CamKII activity through ionotropic but not metabotropic glutamate receptors . ^^^ A model in which cooperative interaction between NMDA and non NMDA glutamate receptors / ion channels is presented to explain the glutamate stimulated increases in CamKII activity in the retina . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Calcium influx through the N methyl d aspartate ( NMDA ) type glutamate receptor and activation of calcium / calmodulin dependent kinase 2 ( CaMKII ) are critical events in certain forms of synaptic plasticity . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The aims of this study were to investigate the involvement of ionotropic glutamate receptors , especially those of the NMDA subtype , and the requirement for Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in these phenomena . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| As ionotropic glutamate receptors are known substrates of CAMKII , this study set out to determine if the protein levels of ionotropic glutamate receptors in the rdta mouse retina are also affected . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Calcium and calmodulin dependent protein kinase 2 ( CaMKII ) and glutamate receptors are integrally involved in forms of synaptic plasticity that may underlie learning and memory . ^^^ Here we show that regulated CaMKII interaction with two sites on the NMDA receptor subunit NR2B provides a mechanism for the glutamate induced translocation of the kinase to the synapse in hippocampal neurons . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In cultures , glutamate induced thickening of PSDs and the accumulation of CaMKII on PSDs are reversed within 5 min of removal of glutamate and Ca ( 2+ ) from the extracellular medium . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The effect of environmental enrichment on NR 1 and BDNF gene expression was specific to Pb2+ exposed animals and was present in the absence of changes in the NR2B subunit of the N methyl D aspartate receptor , GluR 1 , alpha CamKII , or PSD 95 gene expression measured in the same animals . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that NCAM increased the expression levels of CaMKII , p MAPK , GluR 1 and NR 1 but decreased p STAT 3 . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The above results indicate that intra amygdaloid injection of KA produces excitatory signals for ipsilateral CA 3 neurons in the hippocampus and that subsequently increased levels of CaMKII in postsynaptic neurons induce neuronal injury via phosphorylation of N methyl D aspartate type glutamate receptor . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors control phosphorylation of CREB , Elk 1 and ERK via a CaMKII dependent pathway in rat striatum . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Activation of CaMKII has been shown to phosphorylate the glutamate receptor 1 subunit of the AMPA receptor ( AMPAR ) , thereby affecting some of the properties of the receptor . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Calcium / calmodulin dependent protein kinase type 2 ( CaMKII ) and NMDA type glutamate receptor ( NMDAR ) are neuronal proteins involved in learning and memory . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Further , the activation of glutamate receptors increases the association of p 35 and p 39 with CaMKIIalpha , and the inhibition of CaMKII activation diminishes this effect . ^^^ The glutamate mediated increase in association of p 35 and CaMKIIalpha is mediated in large part by NMDA receptors , suggesting that cross talk between the Cdk 5 and CaMKII signal transduction pathways may be a component of the complex molecular mechanisms contributing to synaptic plasticity , memory , and learning . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Calcium / calmodulin dependent protein kinase 2 ( CaMKII ) and the ionotropic glutamate receptors ( iGluRs ) have been shown to be pivotal in the maturation of synapses during development of the central nervous system . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Recent evidence shows that calcium / calmodulin dependent kinase 2 ( CaMKII ) is also upregulated early in the process of central sensitization and that several types of ionotropic glutamate receptors become phosphorylated . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The role of NMDA glutamate receptors , PKA , MAPK , and CAMKII in the hippocampus in extinction of conditioned fear . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| As to subcellular neurochemical mechanisms of sensitization , the activation of three main cascades is indispensable , 1 ) D 1 dopamine ( DA ) receptors / PKA / phospho 34Thr DARPP 32 / PP 1 cascade activated by psychostimulant induced enhancement of DA release in the accumbens , 2 ) NMDA receptors and CaM KII activated by enhanced release of glutamate , 3 ) activation of MAP kinase cascade by BDNF and beta 1 subunit of G protein . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NGF significantly increased the depolarization induced activation of Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) and the subsequent phosphorylation of synapsin 1 in the absence of external Ca2+ and the NGF effect on evoked glutamate release was inhibited by the CaMKII inhibitors KN 93 and CaMKII 281 309 peptide but not by the MAP kinase inhibitor PD 98059 . ^^^ Thus , the effect of NGF on evoked glutamate release is linked to an increase in [ Ca2+ ] 1 contributed by both Ca2+ entry and mobilization from InsP 3 sensitive , ryanodine sensitive and mitochondrial stores and to the subsequent activation of CaMKII . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Consistently , we show that glutamate receptor mutants also have a higher number of T bars ; this increase is suppressed by postsynaptic activation of CaMKII . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here we show that SAP 97 is enriched at the postsynaptic density where it co localizes with both ionotropic glutamate receptors and downstream signaling proteins such as Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Measurements of gene expression following CPB revealed significantly increased levels of mRNA for NMDAR 1 , DARPP 32 , CamKII , GluR 1 , and D1AR . ^^^ DHCA caused changes similar to those for CPB in levels of mRNA for NMDAR 1 , DARPP 32 , CamKII and GluR 1 . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Interactions with various subunits of the NMDA ( N methyl D aspartate ) subtype of glutamate receptor have attracted the most attention , but binding of CaMKII to cytoskeletal and several other regulatory proteins has also been reported . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The interaction of calcium / calmodulin dependent protein kinase 2 ( CaMKII ) with the NR2B subunit of N methyl D aspartate type glutamate receptor is thought to be one of the important events leading to synaptic plasticity . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Treatment of neurons with 5 microm glutamate stimulated CaMKII phosphorylation of nNOS at Ser ( 847 ) , whereas excitotoxic concentrations of glutamate , 100 and 500 microm , induced Ser ( 847 ) PO ( 4 ) dephosphorylation by protein phosphatase 1 . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The membrane expression of key molecules in memory consolidation , such as the NR 1 and NR2B subunits of the N methyl D aspartate ( NMDA ) receptor , Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) and protein phosphatase 1 ( PP 1 ) was measured . ^^^ RESULTS : In hippocampal membrane extracts , passive avoidance training increased NMDA receptor NR 1 subunit expression as well as CaMKII levels and phosphorylated CaMKII . ^^^ In untrained rats , MDMA reduced NR 1 and NR2B protein levels , membrane CaMKII levels and enzyme activity , and enhanced PP 1 levels and activity . ^^^ In trained rats , MDMA prevented the learning specific increase in NR 1 subunit expression and membrane CaMKII / pCaMKII levels . ^^^ After pronounced 5 HT depletion by PCPA , MDMA impaired passive avoidance retention to a similar extent and also prevented the training associated changes in NR 1 levels and CaMKII activity . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Further , CaMKII dependent SAP 97 Ser 39 phosphorylation determined a redistribution of the glutamate receptor subunit ( GluR 1 ) of the AMPA receptor . ^^^ In conclusion , our data show that CaMKII dependent SAP 97 Ser 39 phosphorylation regulates the association of SAP 97 with the postsynaptic complex , thus providing a fine molecular mechanism responsible for the synaptic delivery of SAP 97 interacting proteins , i . e . ionotropic glutamate receptor subunits . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here we report that KN 93 , a membrane permeable CaMKII inhibitor , blocked glutamate induced increases in the frequency of miniature excitatory postsynaptic currents ( mEPSCs ) and the number of presynaptic functional boutons in cultured hippocampal pyramidal neurons . ^^^ In addition , presynaptic injection of the membrane impermeable CaMKII inhibitor peptide 281 309 blocked synaptic plasticity induced by tetanus , glutamate , or NO / cGMP pathway activation as expressed by long lasting increases in EPSC amplitude and functional presynaptic boutons . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Co addition of the protein kinase C ( PKC ) inhibitor GF109203X and the Ca ( 2+ ) calmodulin dependent kinase 2 ( CaMKII ) inhibitor KN 93 blocked the ability of glutamate and carbachol to increase the association of GRK 2 with mGluR1a . ^^^ However , unlike mGluR1a , glutamate stimulated association of GRK 2 with mGluR1b was not reduced by PKC / CaMKII inhibition . ^^^ These results demonstrate that the internalization of mGluR1a , triggered homologously by glutamate or heterologously by carbachol , is PKC / CaMKII , GRK 2 , arrestin , and clathrin dependent and that PKC / CaMKII activation appears to be necessary for GRK 2 to associate with mGluR1a . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The increased levels of extracellular glutamate , NMDA receptor zeta subunit ( NR 1 ) mRNA , NMDA receptor epsilon 1 subunit ( NR2A ) protein , phosphorylated Ca ( 2+ ) / calmodulin kinase 2 ( p CaMKII ) protein , c fos mRNA , c Fos protein , are observed in the specific brain areas of mice and / or rats showing signs of naloxone precipitated withdrawal . ^^^ The activation of CaMKII and increased expression of c Fos protein in the brain of animals with naloxone precipitated withdrawal syndrome are prevented by NMDA receptor antagonists , whereas the increased levels of extracellular glutamate are not prevented by them . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The present findings also suggest that glutamate agonist induced activation of CaM KII in the VTA plays a critical role in the behavioral and neuronal plasticity induced by repeated cocaine injections . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Long term potentiation or depression of synaptic function often requires Ca2+ influx via NMDA type glutamate receptors ( NMDARs ) and changes in the autophosphorylation of Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) at Thr 286 . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Protein synthesis dependent late phase LTP ( L LTP ) in the hippocampus requires calcium influx through the NMDA type glutamate receptor ( NMDA R ) to activate CaMKII as well as concomitant inhibition of PP 1 mediated by protein kinase A . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In addition , the autocamtide 2 related inhibitory peptide ( AIP ) , a specific inhibitor of CaMKII , was used to determine the involvement of CaMKII in glutamate induced RGC 5 cell death . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| However , phosphorylation of the CaMKII PP 1 substrate , Ser 831 in the glutamate receptor GluR 1 subunit , was increased only after sustained ( 9 20 months ) dopamine depletion . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here , we show that in transgenic mice overexpressing the human AD gene APPswe ( Tg 2576 ) , safflower oil induced n 3 PFA deficiency caused a decrease in N methyl D aspartate ( NMDA ) receptor subunits , NR2A and NR2B , in the cortex and hippocampus with no loss of the presynaptic markers , synaptophysin and synaptosomal associated protein 25 ( SNAP 25 ) . n 3 PFA depletion also decreased the NR 1 subunit in the hippocampus and Ca2+ / calmodulin dependent protein kinase ( CaMKII ) in the cortex of Tg 2576 mice . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We base our models on published biochemical data and experiments on the activity dependent movement of a glutamate receptor , AMPAR , and a calcium dependent kinase , CaMKII . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In these rats , however , another drug challenge produced a rapid reduction in PSD 95 immunoreactivity and prevented the learning specific increase in the NMDA receptor NR 1 subunit and phosphorylated CaMKII . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Extensive studies have shown that long term potentiation ( LTP ) of the excitatory postsynaptic current ( EPSC ) through glutamate receptors is induced by activation of N methyl D asparate receptor ( NMDA R ) the coincidence detector and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In contrast , puncta immunopositive for the NR 1 subunit were most numerous at the surface , as were puncta immunopositive for the NR 2 subunit , SynGAP , and CaMKII . ^^^ Approximately eighty five percent of VGLUT 1 positive puncta in layers 2 3 of SI are associated with NR 1 positive puncta , and approximately 80 % are associated with NR 2 , SynGAP , and CaMKII . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation is catalyzed by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) activity , as a result of activation of NR2B containing N methyl D aspartate subtype of glutamate receptors ( NMDARs ) during ischemia . ^^^ Specific blockade of NMDAR / CaMKII ASIC coupling may reduce neuronal death after ischemia and other pathological conditions involving excessive glutamate release and acidosis . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Inhibition of CaMKII by m AIP did not affect expression but significantly enhanced the release of BDNF from glutamate challenged cells . ^^^ A novel mechanism for neuroprotection is proposed for the CaMKII inhibitor , AIP , which appears to protect RGC 5 cells from cytotoxicity by enhancing the release of BDNF from glutamate challenged cells . . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Concomitant with the synaptic accumulation of alpha CaMKII in response to D 4 receptor activation , a D 4 induced increase in the CaMKII phosphorylation of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) receptor glutamate receptor 1 ( GluR 1 ) subunits and the amplitude of AMPA receptor mediated excitatory postsynaptic currents was also observed . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here we show that variability of human memory performance is related to variability in genes encoding proteins of this signaling cascade , including the NMDA and metabotrobic glutamate receptors , adenylyl cyclase , CAMKII , PKA , and PKC . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| This increase in Ser 19 phosphorylation was associated with enhanced TH activity and was due , in part , to glutamate receptor mediated calcium influx and possibly calcium / calmodulin dependent protein kinase 2 ( CaMKII ) activation . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We show that the calcium dependent effect on postsynaptic quantal size is mediated by group 1 metabotropic glutamate receptors , acting via CaMKII ( Ca2+ / calmodulin dependent protein kinase 2 ) and PKC . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Glutamate or NMDA stimulation induced CaMKII autophosphorylation over a time course that mirrored the time course of p 35 degradation . ^^^ |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13555 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|