| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The activity of NMDA ( N methyl D aspartate ) receptors is mechanosensitive and dependent on the integrity of actin , suggesting a functionally important interaction between NMDA receptors and the postsynaptic cytoskeleton . alpha Actinin 2 , a member of the spectrin / dystrophin family of actin binding proteins , is identified here as a brain postsynaptic density protein that colocalizes in dendritic spines with NMDA receptors and the putative NMDA receptor clustering molecule PSD 95 . alpha Actinin 2 binds by its central rod domain to the cytoplasmic tail of both NR 1 and NR2B subunits of the NMDA receptor , and can be immunoprecipitated with NMDA receptors and PSD 95 from rat brain . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| To determine their roles in the assembly of glutamatergic postsynaptic sites , we studied the distributions of NMDA and AMPA type glutamate receptors ; the NMDA receptor interacting proteins alpha actinin 2 , PSD 95 , and chapsyn ; and the PSD 95 associated protein GKAP during the development of hippocampal neurons in culture . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Recently the actin binding protein alpha actinin 2 was shown to bind directly to the NMDA receptor subunits NR 1 and NR2B ( ) , suggesting that alpha actinin 2 may function to attach NMDA receptors to the actin cytoskeleton . ^^^ By immunogold electron microscopy , alpha actinin 2 is concentrated over the postsynaptic density ( PSD ) of numerous asymmetric synapses where it colocalizes with NR 1 immunoreactivity . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this inactivating effect of calmodulin can be prevented by coexpressing a region of the cytoskeletal protein alpha actinin 2 known to interact with the CO region of NR 1 . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Additional clustering of NMDA receptors is provided through the binding of NRI subunits to the cytoskeletal protein alpha actinin 2 . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| A multi mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin , alpha actinin 2 and a glutamate receptor in differentiated PC 12 cells . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Reduced ethanol inhibition of N methyl D aspartate receptors by deletion of the NR 1 C0 domain or overexpression of alpha actinin 2 proteins . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Alpha actinin ( alpha actinin 2 ) is a protein which links the NR 1 and NR2B subunits of N methyl D aspartate ( NMDA ) glutamate receptors to the actin cytoskeleton . ^^^ A subunit specific anti NR 1 antibody co precipitated major fractions of NR2A and NR2B subunits , but only a minor fraction of striatal alpha actinin 2 . ^^^ Conversely , alpha actinin 2 antibody immunoprecipitated only modest fractions of striatal NR 1 , NR2A and NR2B subunits . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Like Ca ( 2+ ) / calmodulin , autophosphorylated CaMKII competes with alpha actinin 2 for binding to NR 1 . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We offer a novel mechanism describing this attenuation in which PP 1 and 2A dephosphorylate the NMDAR ( NR 1 subunit ) followed by calmodulin binding , a subsequent dissociation of alpha actinin 2 from the NR 1 subunit , and a decrease in NMDAR activity . . ^^^ |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35609 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
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