| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| When indirect responses were blocked by adding tetrodotoxin ( 0 . 2 microM ) or manganese chloride ( 2 mM ) to the normal Ringer solution , AMBD ( 0 . 01 0 . 5 mM ) selectively antagonized taurine , beta alanine , hypotaurine and kojic amine evoked depolarizations of primary afferents at their intramedullary part ( dorsal root terminals , DRT ) and on dorsal root ganglia ( DRG ) , without significantly affecting responses to glutamate ( on DRT ) , glycine ( on DRT ) or GABA ( on DRT and DRG ) . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the DRt was performed by injecting glutamate ( 100 nmol / microliters ) unilaterally , which was followed 1 min later by a significant decrease in the tail flick latency compared to saline injected controls . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| DRt blocking by lidocaine results in a decrease of the nociceptive activity of spinal dorsal horn neurones , whereas stimulation by glutamate has the opposite effect . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Replacement by glutamate rendered the kinase capable of being activated by ERK activator , while replacement by alanine did not . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The chronic morphine induced increases in ERK activity and TH expression in the VTA also were blocked by local infusion of NMDA glutamate receptor antagonists , suggesting a role for glutamate in mediating these drug effects . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Conversion of L 12 of p 38 to an `` ERK like ' ' structure was accomplished in several ways : ( 1 ) by replacing glycine with glutamate in the dual phosphorylation site , ( 2 ) by placing a six amino acid sequence present in L 12 of ERK ( but absent in p 38 ) into p 38 , and ( 3 ) by mutations of amino acid residues in loop 12 . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| These latter bring about on the one hand a raising of [ Ca2+ ] 1 partly due to the potentiation of the NMDA receptor response to endogenous glutamate and on the other hand the activation of certain MAP kinases ( ERK and JNK ) which lead to the initiation of the cell death program . . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In cultured hippocampal neurons , simulation of glutamate receptors can activate ERK signaling , for which elevation of intracellular Ca2+ is required . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Glutamate treatment leads to a robust , progressive activation of the ERK and JNK / SAPK MAPK cascades . ^^^ ERK and Elk 1 phosphorylation are blocked by the MAPK kinase inhibitor PD 98059 , indicating the primary role of the ERK cascade in mediating glutamate signaling to Elk 1 in the rat striatum in vivo . ^^^ Interestingly , KN 62 , which interferes with calcium calmodulin kinase ( CaM K ) activity , leads to a reduction of glutamate induced ERK activation and of CREB phosphorylation . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Activation of metabotropic glutamate receptors ( mGluRs ) leads to modulation of a variety of second messenger pathways probably including the mitogen activated protein kinase ( MAPK ) extracellular signal regulated protein kinases ( ERK ) . ^^^ However , glutamate stimulated ERK activation remained unaffected . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons . ^^^ However , SAPK and ERK can also be coordinately activated in neurons in response to glutamate stimulation of NMDA receptors . ^^^ To explore the mechanisms of these MAPK activations , we compared the ionic mechanisms mediating SAPK and ERK activations by glutamate . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Glutamate stimulated calcium activation of Ras / Erk pathway mediated by nitric oxide . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that increased expression of genes encoding the following proteins are involved in oligodendroglial differentiation : Fyn , Erk , p 85 , G alpha 12 guanine nucleotide binding , and transducin beta 2 signal transduction molecules ; glial maturation factor ; the proteasomal subunits C 8 and C 3 ; the proteasomal targeting molecule polyubiquitin ; the cell cycle regulatory proteins Set , protein phosphatase 2A , and nuclear tyrosine phosphatase ( PRL 1 ) ; and the high affinity glutamate cotransporter EAAC 1 . . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In this paper , the functional effects of IL 6 on the spread of excitation visualized by dark field / infrared videomicroscopy in rat cortical slices and on glutamate release from cortical synaptosomes were analysed and correlated with the activation of the STAT 3 , mitogen activated protein kinase ERK ( MAPK / ERK ) and stress activated protein kinase / cJun NH 2 terminal kinase ( SAPK / JNK ) pathways . ^^^ We have found that IL 6 depresses the spread of excitation and evoked glutamate release in the cerebral cortex , and that these effects are accompanied by a stimulation of STAT 3 tyrosine phosphorylation , an inhibition of MAPK / ERK activity , a decreased phosphorylation of the presynaptic MAPK / ERK substrate synapsin 1 and no detectable effects on SAPK / JNK . ^^^ The inhibitory effects of IL 6 on glutamate release and on the spread of excitation in the rat cerebral cortex indicate that the protective effect of IL 6 on neuronal survival could be mediated by a downregulation of neuronal activity , release of excitatory neurotransmitters and MAPK / ERK activity . . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Persistent activation of ERK contributes to glutamate induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures . ^^^ Furthermore , we find that U 0126 , a specific inhibitor of the ERK activating kinase , MEK 1 / 2 , protects both HT 22 cells and immature primary cortical neuron cultures from glutamate toxicity . ^^^ Glutamate induced ERK activation requires the production of specific arachidonic acid metabolites and appears to be downstream of a burst of reactive oxygen species ( ROS ) accumulation characteristic of oxidative stress in HT 22 cells . ^^^ However , inhibition of ERK activation reduces glutamate induced intracellular Ca ( 2+ ) accumulation . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Activation of pp 60 ( c Src ) kinase and phosphorylation of ERK were observed in response to glutamate treatment . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here , we show that a novel MAPK / ERK kinase ( MEK ) specific inhibitor U 0126 profoundly protected HT 22 cells against oxidative stress induced by glutamate , which was accompanied by an inhibition of phosphorylation of ERK1 / 2 . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Glutamate receptors of NMDA subtypes also participated in ERK activation , as shown after injection of the NMDA receptor antagonist MK 801 . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The members of the mitogen activated protein ( MAP ) kinase family p44 / p42 MAP kinase ( ERK ) , c jun N terminal kinase ( JNK ) and p 38 MAP kinase ( p 38 ) are known to be important mediators of the physiological plasticity or neurotoxicity induced in the striatum by activation of ionotropic glutamate receptors . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Inhibitor analysis as well as immunochemical characterization has indicated that the MEK ( MAPK / ERK kinase ) ERK ( extracellular signal regulated kinase ) cascade plays an indispensable role in glutamate stimulated induction of Homer 1a mRNA . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| These changes are accompanied by increased activation of one member of the family of mitogen activated protein kinases , extracellular signal regulated kinase ( ERK ) and the data indicate that these events play a role in modulating release of glutamate from perforant path granule cell synapses , because the Trk inhibitor K252a and the ERK inhibitor , UO 126 , both inhibited the BDNF induced enhancement of release . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| DA D 2 and glutamate receptors of NMDA subtypes also participate , albeit to a lesser extent , to THC induced ERK activation in the striatum , as shown after injection of selective antagonists ( raclopride and MK 801 , respectively ) . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| This process follows the stimulation of both N methyl D aspartate and metabotropic glutamate receptors and involves the activation of the mitogen activated protein kinase ERK via protein kinase C . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| To evaluate putative roles of group 1 metabotropic glutamate receptors ( mGluRs ) in CREB , Elk 1 , and ERK phosphorylation , the group 1 selective agonist , 3 , 5 dihydroxyphenylglycine ( DHPG ) , was infused into the dorsal striatum at doses of 125 , 250 , or 500 nmol in freely moving rats . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors control phosphorylation of CREB , Elk 1 and ERK via a CaMKII dependent pathway in rat striatum . ^^^ In vivo activation of group 1 metabotropic glutamate receptors ( mGluRs ) upregulates phosphorylation of cyclic AMP response element binding protein ( CREB ) , Elk 1 and extracellular signal regulated kinases ( ERK ) in striatal neurons . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Stimulation of glutamate receptors with 100 microM kainate or 100 microM glutamate for 2 min was sufficient to induce the activation of the extracellular signal regulated kinase ( ERK ) . ^^^ Inhibition of the ERK activation with the MEK inhibitors U 0126 and PD 98059 increased the toxicity induced by kainate but was without effect on the toxicity induced by glutamate . ^^^ These results indicate that , although stimulation with both glutamate receptor agonists increased ERK phosphorylation , only kainate induced ERK activation correlates with the activation of a survival signaling pathway . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In order to investigate a role for the extracellular signal regulated kinases 1 and 2 ( ERK1 / 2 ) on hippocampal neurotransmitter release , we studied the effect of commonly used MEK ( mitogen activated protein kinase [ MAPK ] / ERK kinase ) inhibitors , PD 098 , 059 and U 0126 , on depolarization induced glutamate release . ^^^ U 0126 , however , did not significantly affect KCl evoked glutamate release at concentrations shown to inhibit ERK activity . ^^^ PD 098 , 029 and U 0126 showed a small dose dependent inhibitory effect on ionomycin induced glutamate release , at concentrations shown to inhibit ionomycin stimulated ERK phosphorylation . ^^^ These findings uncover new unspecific actions for both MEK inhibitors and suggest a minor role for ERK in modulating glutamate release in the hippocampus . . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Glutamate release was also enhanced , and the data suggest that this may be a consequence of increased activation of TrkB and ERK . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Reintroduction of wild type Tob and mutant Tob with serine to alanine but not to glutamate mutations on the Erk phosphorylation sites in these cells restores the suppression of cyclin D 1 expression . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Moreover , FGF 1 protection against glutamate toxicity was dependent on GSK3beta inactivation by the PI3K Akt but was independent of ERK . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors , mGlu1a and mGlu5a , couple to extracellular signal regulated kinase ( ERK ) activation via distinct , but overlapping , signalling pathways . ^^^ The coupling of the group 1 metabotropic glutamate receptors , mGlu1a and mGlu5a , to the extracellular signal regulated protein kinase ( ERK ) pathway has been studied in Chinese hamster ovary cell lines where receptor expression is under inducible control . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We used an immunocytochemical approach to examine ERK activation by muscarinic acetylcholine ( mAChR ) , metabotropic glutamate ( mGluR ) , and beta adrenergic ( beta AR ) receptors in CA 1 neurons of mouse hippocampal slices . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Finally , the effects of cannabinoids on ERK activation were dependent on the activity of glutamate NMDA receptors in vivo , but not in hippocampal slices , indicating the existence of several pathways linking CB 1 R to the ERK cascade . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Erk activation is required for Nrf 2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG 2 cells . ^^^ Pyrrolidine dithiocarbamate ( PDTC ) induction of the human glutamate cysteine ligase modulatory ( GCLM ) gene is dependent on activation of the mitogen activated protein kinases ( MAPKs ) extracellular regulated kinase ( Erk ) and p 38 , and is not affected by protein kinase C ( PKC ) or PI3K inhibitors . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We have recently found that Alzheimer ' s disease amyloid beta protein ( Abeta ) activates the extracellular signal regulated kinase ( ERK ) and promotes L glutamate uptake in astrocytes . ^^^ To elucidate the relationship between the Abeta induced ERK phosphorylation and promotion of L glutamate uptake , we investigated the effects of U 0126 and PD 98059 , specific inhibitors of the ERK activating enzyme MEK , in cultured rat cortical astrocytes . ^^^ Abeta induced ERK phosphorylation was completely blocked by the MEK inhibitors , while Abeta induced promotion of extracellular L glutamate clearance was enhanced by the presence of the MEK inhibitors . ^^^ The effective concentrations of MEK inhibitors in enhancing Abeta induced promotion of glutamate clearance and GLAST expression were consistent with those in blocking Abeta induced ERK phosphorylation . ^^^ These results suggest that the MEK / ERK signal functions to suppress Abeta induced upregulation of a glutamate uptake system in astrocytes . . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Exogenous nitric oxide ( NO ) donors ( S nitroso N acetyl DL penicillamine and ( E ) 4 ethyl 2 [ ( E ) hydroxyimino ] 5 nitro 3 hexenamide ) and simultaneous application of high potassium and glutamate led to the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 / 2 in cerebellar Purkinje cells . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of ERK1 / 2 induced by TPA and co application of high potassium and glutamate was greatly attenuated by preincubating Purkinje cells with the MEK1 / 2 ( MAPK ERK kinase 1 / 2 ) inhibitor PD 98059 . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Glutamate transmission via NMDA and mGluR 1 but not AMPA receptors was critical to this ERK activation . ^^^ In conclusion , glutamate and BDNF are the important C fiber signaling components for ERK activation in dorsal horn neurons . . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We have previously determined that glutamate induced oxidative toxicity is accompanied by a robust increase in activation of the mitogen activated protein kinase ( MAPK ) member extracellular signal regulated kinase ( ERK ) and that this activation is essential for neuronal cell death . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Developmentally regulated role for Ras GRFs in coupling NMDA glutamate receptors to Ras , Erk and CREB . p 140 Ras GRF 1 and p 130 Ras GRF 2 constitute a family of calcium / calmodulin regulated guanine nucleotide exchange factors that activate the Ras GTPases . ^^^ Studies on mice lacking these exchange factors revealed that both p 140 Ras GRF 1 and p 130 Ras GRF 2 couple NMDA glutamate receptors ( NMDARs ) to the activation of the Ras / Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NR 1 phosphorylation induced by BDNF was blocked by a TrkB inhibitor , an ERK inhibitor and a PKC inhibitor but not a PKA inhibitor . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| These results suggest that glutamate released from corticostriatal afferents modulates the ability of amphetamine to engage striatopallidal neurons through an ERK / MAPK signaling dependent mechanism . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In the present study we found that the epidermal growth factor activated ERK 2 in cerebellar granule neurons and that this activation prohibited glutamate induced subcellular translocation of NGFI B . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In young rats , BDNF LTP was accompanied by increased activation of the BDNF receptor TrkB , and extracellular signal regulated kinase ( ERK ) , as well as enhanced evoked release of glutamate in synaptosomes prepared from DG . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here we investigated the interaction between NMDA receptors and metabotropic glutamate receptor 5 ( mGluR 5 ) in the integral regulation of extracellular signal regulated protein kinase ( ERK ) and gene expression in cultured rat striatal neurons . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum . ^^^ Here , we show in mouse that d amphetamine activates ERK in a subset of medium size spiny neurons of the dorsal striatum and nucleus accumbens , through the combined action of glutamate NMDA and D 1 dopamine receptors . ^^^ Thus , activation of ERK , by a multilevel protein phosphatase controlled mechanism , functions as a detector of coincidence of dopamine and glutamate signals converging on medium size striatal neurons and is critical for long lasting effects of drugs of abuse . . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Influx of calcium , mediated either by L type voltage sensitive calcium channels or glutamate receptors , is associated with the suppression of brain derived neurotrophic factor ( BDNF ) activation of Ras and its effectors Erk and Akt . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NMDA and TrkB receptor activation thus converge on the extracellular signal regulated kinase ( ERK ) 1 / 2 signaling pathway to protect neurons against glutamate mediated excitotoxicity . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Neuroprotection by BDNF against glutamate induced apoptotic cell death is mediated by ERK and PI 3 kinase pathways . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Of interest , N methyl d aspartate ( NMDA ) , non NMDA and metabotropic glutamate receptor antagonists all blocked Hcy induced ERK activation . ^^^ Thus , altogether these data support a role of Hcy on ERK activation , via complex mechanisms , starting with a control of glutamate release , which in turn activates ionotropic and metabotropic receptor subtypes and produces increases in intracellular calcium levels . . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Blockade of the ERK cascade with the MEK inhibitor PD 98059 inhibited phosphorylation of ELK 1 , activation of NF kB and gene expression of NR 1 , NR 2A and NK 1R , and prevented the development of excessive grooming behavior . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| RESULTS : ( 1 ) Par 4 AS ODN significantly suppressed up regulation of the par 4 protein levels induced by glutamate in PC 12 cells . ( 2 ) Par 4 AS ODN could resist the decrease of phosphorylated ERK ( 1 / 2 ) ( Thr202 / Tyr204 ) induced by glutamate in PC 12 cells . ( 3 ) Par 4 AS ODN could inhibit apoptosis of PC 12 cells induced by glutamate . ^^^ CONCLUSION : Par 4 AS ODN may inhibit apoptosis of PC 12 cells induced by glutamate , and its inhibition effects may be medicated by the activation of ERK ( 1 / 2 ) . . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We propose two independent neuronal death pathways by tributyltin ; one is glutamate receptor dependent cell death via ERK phosphorylation , and the other may be glutamate receptor independent cell death via p 38 activation . . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Age dependent participation of Ras GRF proteins in coupling calcium permeable AMPA glutamate receptors to Ras / Erk signaling in cortical neurons . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that glutamate and substance P ( SP ) , two principal mediators of sensory information between primary afferent fibers and the spinal cord , activate Erk in dorsal horn neurons of both adult rat and mouse spinal cord . ^^^ In genetic knock out mice of calcium calmodulin stimulated adenylyl cyclase subtypes 1 ( AC 1 ) and 8 ( AC 8 ) , activation of Erk in dorsal horn neurons were significantly reduced or blocked , either after peripheral tissue inflammation or by glutamate or SP in spinal cord slices . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| This procedure also abolished the phosphorylation of ERK and glutamate receptor 1 observed in the ventral and dorsal striatum , 24 h later , during CPP test . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The small effect of BDNF on [ ( 3 ) H ] glutamate release correlated with a modest increase in phospholipase Cgamma ( PLCgamma ) phosphorylation , and with the lack of effect of BDNF on extracellular signal regulated kinase ( ERK ) and Akt phosphorylation . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin ( mTOR ) and extracellular signal regulated kinase ( ERK 1 / 2 ) signaling pathways in rat striatal and hippocampal synaptoneurosomes . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| As a result , simultaneous activation of both extrasynaptic and synaptic NMDAR using bath application of NMDA or glutamate ( a typical protocol explored in the majority of studies ) produced ERK activation that depended on the concentration of agonists and was always significantly weaker than those mediated by synaptic NMDARs . ^^^ Since the activation of the extrasynaptic NMDA is attributed mainly to global release of glutamate occurring at pathological conditions including hypoxic / ischaemic insults , traumas and epileptic brain damage , the reported differential regulation of ERK cascade by NMDARs provides a unique mechanism for an early identification of the physiological and / or pathophysiological consequences of NMDAR activation . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The current study demonstrated that the selective mGlu 5 receptor positive allosteric modulator , N { 4 chloro 2 [ ( 1 , 3 dioxo 1 , 3 dihydro 2H isoindol 2yl ) methyl ] phenyl } 2 hydrobenzamide ( CPPHA ) potentiated the response to a subthreshold concentration of 3 , 5 dihydroxy phenylglycine ( DHPG ) on extracellular signal regulated protein kinase ( ERK ) and cyclic AMP responsive element binding protein ( CREB ) activity , as well as N methyl d aspartate ( NMDA ) receptor subunit NR 1 phosphorylation in cortical and hippocampal slices . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Involvement of ERK and CREB signaling pathways in the protective effect of PACAP in monosodium glutamate induced retinal lesion . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Synaptic NMDA mediated current was reduced in dentate granule neurons in EphB 2 null mice , as was synaptically localized NR 1 as revealed by immunogold localization . ^^^ |
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| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Numb formed a complex with EphB 2 receptor type tyrosine kinase and NMDA type glutamate receptors . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Expression of the cefG gene from the promoters of ( 1 ) the glyceraldehyde 3 phosphate dehydrogenase ( gpd ) gene of Aspergillus nidulans , ( 2 ) the glucoamylase ( gla ) gene of Aspergillus niger , ( 3 ) the glutamate dehydrogenase ( gdh ) and ( 4 ) the isopenicillin N synthase ( pcbC ) genes of Penicillium chrysogenum , led to very high steady state levels of cefG transcript and to increased deacetylcephalosporin C acetyltransferase protein concentration ( as shown by immunoblotting ) and enzyme activity in the transformants . ^^^ |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|