| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| S1P induces FA remodeling in human pulmonary endothelial cells : role of Rac , GIT 1 , FAK , and paxillin . ^^^ |
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| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We propose that GIT 1 and FAK cooperate to promote motility both by directly regulating focal complex dynamics and by the activation of Rac . . ^^^ |
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| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that S1P induced focal adhesion ( FA ) remodeling involves interactions between focal adhesion kinase ( FAK ) , paxillin , and G protein coupled receptor kinase interacting proteins GIT 1 and GIT 2 and suggested a critical involvement of focal adhesions in the EC barrier regulation . ^^^ In this study , we examined redistribution of FA proteins ( FAK , paxillin , GIT 1 , and GIT 2 ) and site specific FAK tyrosine phosphorylation in human pulmonary artery endothelial cells stimulated with thrombin . ^^^ |
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| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| In human umbilical vein ECs ( HUVECs ) , thrombin recruited GIT 1 to FAs , where GIT 1 colocalized with FAK and vinculin . ^^^ Thrombin stimulated GIT 1 tyrosine phosphorylation with a time course similar to FAK phosphorylation in a Rho kinase and Src dependent manner . ^^^ Depletion of GIT 1 with antisense GIT 1 oligonucleotides had no effect on basal cell morphology , but increased cell rounding and contraction of HUVECs , increased FA formation , and increased FAK tyrosine phosphorylation in response to thrombin , concomitant with increased endothelial hyperpermeability . ^^^ |
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| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Transfection of the cells with specific p 85 beta PIX siRNA led to drastic inhibition of LPA induced FAK phosphorylation , peripheral redistribution of p 85 beta PIX with FAK and GIT 1 , and cell motility . p 85 beta PIX was also required for p 38 MAP kinase phosphorylation induced by LPA . ^^^ |
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| Interacting proteins: Q9Y2X7 and Q05397 |
Pubmed |
SVM Score :0.0 |
| The absence of either FAK or Src family kinases prevents PKL phosphorylation and suppresses localization of PKL but not GIT 1 to focal adhesions after Rac activation . ^^^ |
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