| Interacting proteins: Q8TDY2 and Q05397 |
Pubmed |
SVM Score :1.3788478 |
| Last , we show that disruption of the functional interaction between endogenous FIP 200 with FAK leads to increased FAK phosphorylation and partial restoration of cell cycle progression in cells plated on poly L lysine , providing further support for FIP 200 as a negative regulator of FAK . 1.3788478^^^ We show the association of endogenous FIP 200 with FAK , which is decreased upon integrin mediated cell adhesion concomitant with FAK activation . 0.61476571^^^ |
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| Interacting proteins: Q8TDY2 and Q05397 |
Pubmed |
SVM Score :0.81256088 |
| FIP 200 is a novel protein inhibitor for focal adhesion kinase ( FAK ) , which binds to FAK directly and inhibits its kinase activity and associated cellular functions , such as cell adhesion , spreading , and motility in fibroblasts . 0.81256088^^^ |
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| Interacting proteins: Q8TDY2 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We report the identification of a novel Pyk 2 interacting protein designated FIP 200 ( FAK family kinase interacting protein of 200 kD ) by using a yeast two hybrid screen . ^^^ In vitro binding assays and coimmunoprecipitation confirmed association of FIP 200 with Pyk 2 , and similar assays also showed FIP 200 binding to FAK . ^^^ |
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| Interacting proteins: Q8TDY2 and Q05397 |
Pubmed |
SVM Score :0.0 |
| FIP 200 ( focal adhesion kinase [ FAK ] family interacting protein of 200 kD ) is a newly identified protein that binds to the kinase domain of FAK and inhibits its kinase activity and associated cellular functions . ^^^ Conversely , knockdown of endogenous FIP 200 by RNA interference reduced S 6 kinase phosphorylation and cell size , which required TSC 1 but was independent of FAK . ^^^ |
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