| Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms . ^^^ Expression of MCSP enhances integrin mediated cell spreading , FAK phosphorylation , and activation of ERK1 / 2 . ^^^ Enhanced activation of FAK and ERK1 / 2 by MCSP appears to involve independent mechanisms because inhibition of FAK activation had no effect on ERK1 / 2 phosphorylation . ^^^ |