| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.82406402 |
| Subsequent studies revealed that pp125FAK binds Cas L on its SH 3 domain and phosphorylates its tyrosine residues upon beta 1 integrin stimulation . 0.82406402^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.52681059 |
| Induced Nedd 9 protein was tyrosine phosphorylated and was bound to FAK in dendrite and soma of neurons after the ischemia . 0.52681059^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| These findings further define the roles of pp105 / Cas L and pp125FAK in the integrin mediated signaling pathways . . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We show here that p 130 ( Cas ) and Cas L are FAK substrates . ^^^ The Cas L YDYVHL sequence is phosphorylated upon integrin ligand binding , and this integrin mediated tyrosine phosphorylation is inhibited by the cotransfection of the FAK COOH terminal domain that does not contain a kinase domain . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Furthermore , a Cas L mutant that lacks the SH 3 domain , the binding site for focal adhesion kinase ( FAK ) , is also tyrosine phosphorylated upon CD 3 cross linking , but not upon beta 1 integrin crosslinking , suggesting that FAK is not involved in CD 3 dependent Cas L phosphorylation . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| In the H 9 T cell line , beta 1 integrin engagement leads to the increased tyrosine phosphorylation of three 105 to 115 kDa substrates that are distinct from focal adhesion kinase ( FAK ) : HEF 1 ( human enhancer of filamentation 1 ) , a protein with structural homology to p130Cas , and two novel substrates , pp 105 and pp 115 . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We now show that the cytoplasmic tyrosine kinase , focal adhesion kinase ( FAK ) plays an essential role in the beta 1 integrin stimulated migration of T cells through regulation of the unique Crk associated substrate ( Cas ) family docking protein , human enhancer of filamentation 1 ( HEF 1 ) and effects on `` outside in ' ' beta 1 integrin signaling . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| FAK overexpression and PDGF stimulation was found to increase the phosphorylation of the Crk associated substrate ( CAS ) family member human enhancer of filamentation 1 ( HEF 1 ) , but not p130CAS or Src interacting protein ( Sin ) / Efs , although the levels of expression of these proteins was similar . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Both pp 105 and pp 115 are antigenically distinct from HEF 1 , p130Cas , pp125FAK , Pyk 2 , p120cbl , and the p 110 subunit of phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We found that a focal adhesion kinase ( FAK ) related protein , cell adhesion kinase beta ( CAKbeta ) , was bound in vitro by the SH 3 domain of embryonal Fyn associated substrate ( Efs ) , a docking protein structurally related to p130Cas ( Cas ) and HEF 1 . ^^^ A competitive binding assay showed that Efs , compared with Cas and HEF 1 , had a SH 3 domain with a lower relative affinity to CAKbeta and FAK and with a preference to interact with FAK rather than CAKbeta . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Endogenous HEF 1 is cleaved into 65 and 55 kDa fragments and a newly detected 28 kDa form in response to the induction of apoptosis , paralleling cleavage of poly ( ADP ribose ) polymerase and focal adhesion kinase ( FAK ) ; the death promoting activity of over expressed HEF 1 is associated with production of the 28 kDa form . ^^^ Based on these results , we propose that dysregulation of HEF 1 and its family members along with FAK may signal the destruction of focal adhesion sites and regulate the onset of apoptosis . . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Calcitonin induces the association and tyrosine phosphorylation of focal adhesion kinase ( FAK ) , paxillin , and HEF 1 in HEK 293 cells that overexpress the calcitonin receptor ( C1a HEK ) , but the hormone ' s effect on these adhesion related proteins in osteoclasts is not known . ^^^ We therefore studied the effect of calcitonin on the tyrosine phosphorylation and subcellular distribution of paxillin , HEF 1 , FAK , and Pyk 2 , a FAK related tyrosine kinase , in osteoclasts . ^^^ |
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| Interacting proteins: Q14511 and Q05397 |
Pubmed |
SVM Score :0.0 |
| NA |
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