| Interacting proteins: P51813 and Q05397 |
Pubmed |
SVM Score :0.0 |
| The activation of Etk by extracellular matrix proteins is regulated by FAK through an interaction between the PH domain of Etk and the FERM domain of FAK . ^^^ The lack of Etk activation by extracellular matrix in FAK null cells could be restored by co transfection with wild type FAK . ^^^ Disrupting the interaction between Etk and FAK diminished the cell migration promoted by either kinase . ^^^ Taken together , our data indicate the essential role of the interaction of the PH domain of Etk and the FERM domain of FAK in integrin signalling . . ^^^ |
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| Interacting proteins: P51813 and Q05397 |
Pubmed |
SVM Score :0.0 |
| We found that three nonreceptor tyrosine kinases , focal adhesion kinase ( FAK ) , Src , and Etk / BMX play important parts in this process . ^^^ Etk / Bmx activation requires FAK and Src and is critical for neurotrophic factor induced growth , as LNCaP cells transfected with a dominant negative Etk / BMX fail to respond to bombesin . ^^^ Etk ' s activation requires FAK , Src , but not phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: P51813 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Although the Tyr kinases Src and FAK are known to activate ETK directly , Src is insensitive to AG 879 , and FAK is inhibited by 100 nM AG 879 , but not by 10 nM AG 879 . ^^^ |
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| Interacting proteins: P51813 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Although HUVECs express the non receptor tyrosine kinases Fak , Src , and Etk which mediate neuropeptide signaling in CaP , they are not activated by neuropeptides in HUVECs . . ^^^ |
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