| Interacting proteins: P42224 and Q05397 |
Pubmed |
SVM Score :1.1101698 |
| We found in a yeast two hybrid screen that the N terminal domain of FAK interacted with protein inhibitor of activated STAT 1 ( PIAS 1 ) . 1.1101698^^^ |
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| Interacting proteins: P42224 and Q05397 |
Pubmed |
SVM Score :0.0 |
| In particular , we observe that FAK is capable of activating Stat 1 , but not Stat 3 . ^^^ Co immunoprecipitation and in vitro binding assays demonstrate that Stat 1 is transiently and directly associated with FAK during cell adhesion , and Stat 1 is activated in this process . ^^^ Moreover , Stat 1 activation during cell adhesion is diminished in FAK deficient cells , correlating with decreased migration in these cells . ^^^ Thus , our results have demonstrated , for the first time , a critical signaling pathway from integrin / FAK to Stat 1 that reduces cell adhesion and promotes cell migration . . ^^^ |
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| Interacting proteins: P42224 and Q05397 |
Pubmed |
SVM Score :0.0 |
| A Janus protein tyrosine kinase 2 inhibitor ( AG 490 ) blocked the IFN gamma stimulated tyrosine phosphorylation of STAT 1 , promoter activity of the 4 , 831 to +195 bp region , Nox 1 mRNA expression , and O ( 2 ) ( ) production , also suggesting a crucial role of STAT 1 and GAS in the IFN gamma stimulated transcription of the Nox 1 gene . ^^^ |
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