| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.63735675 |
| Within one minute after stimulation of EphA 2 with its ligand , ephrin A 1 , the protein tyrosine phosphatase SHP 2 is recruited to EphA 2 ; this is followed by dephosphorylation of FAK and paxillin , and dissociation of the FAK EphA 2 complex . 0.63735675^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| A comprehensive analysis of tyrosine kinase expression revealed overexpression or functional activation of the Axl , FAK , and EphA 2 tyrosine kinases in transformed MCF 10A cells . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| EphA 2 , focal adhesion kinase ( FAK ) and p 130 ( cas ) were identified as the major ephrin dependent phosphotyrosyl proteins during the ephrin induced morphological changes . ^^^ These data show that ephrinA 1 can induce cell adhesion and actin cytoskeletal changes in fibroblasts in a FAK and p 130 ( cas ) dependent manner , through activation of the EphA 2 receptor . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Structures of the cancer related Aurora A , FAK , and EphA 2 protein kinases from nanovolume crystallography . ^^^ This report presents the structures of kinase domains for three cancer associated protein kinases : ephrin receptor A 2 ( EphA 2 ) , focal adhesion kinase ( FAK ) , and Aurora A . ^^^ The expression profiles of EphA 2 , FAK , and Aurora A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents . ^^^ The structures were determined from crystals grown in nanovolume droplets , which produced high resolution diffraction data at 1 . 7 , 1 . 9 , and 2 . 3 A for FAK , Aurora A , and EphA 2 , respectively . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| In addition , novel signaling pathways are discussed , involving VE cadherin , EphA 2 , FAK , and PI 3 kinase , which promote cell migration , invasion , and matrix remodeling . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| EphA 2 siRNA suppresses EphA 2 expression , cellular invasiveness , anoikis resistance and FAK phosphorylation in vitro and retards tumor growth and inhibits metastasis in vivo . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| In addition to interactions with multiple signaling adaptors Grb 2 , SHC , SCK , and NSP 2 , EGF receptors in HN 5 cells were shown to form direct or indirect physical interactions with additional kinases including ACK 1 , focal adhesion kinase ( FAK ) , Pyk 2 , Yes , EphA 2 , and EphB 4 . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : We have been investigating various molecules correlated with the malignancy of esophageal squamous cell carcinoma and , in the present study , we examined the correlation of four of them ( KAI 1 , FAK , EphA 2 , Ki 67 labeling index ) with the prognosis of affected patients . ^^^ The malignancy index ( MI ) was defined in terms of the KAI 1 , FAK and EphA 2 scores and the Ki 67 labeling index , and the reliability and utility of the correlation between MI and prognosis was evaluated . ^^^ The rate of concordance between the biopsy samples and surgical specimens was 79 . 4 % for KAI 1 , 88 . 2 % for FAK and 73 . 5 % for EphA 2 , and the rates of concordance for 1 , 2 , 3 , 4 , 5 , 6 , 7 and 8 biopsy samples were 66 . 7 % , 64 . 1 % , 74 . 5 % , 90 . 7 % , 91 . 7 % , 83 . 3 % , 100 % and 100 % , respectively . ^^^ |
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| Interacting proteins: P29317 and Q05397 |
Pubmed |
SVM Score :0.0 |
| NA |
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