| Interacting proteins: P09769 and Q05397 |
Pubmed |
SVM Score :0.0 |
| These molecules include three distinct classes of tyrosine kinases , Syk , FAK , and Fgr , and the functionally diverse proteins Vav and paxillin . . ^^^ |
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| Interacting proteins: P09769 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Five PTK mRNAs ( fgr , hck , fak , jak 2 , and flk 1 ) increased expression across all three models of activation . ^^^ |
|
| Interacting proteins: P09769 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Stimulation with LDL reveals ( 1 ) a major role for Tyr 925 phosphorylation which surpasses the phosphorylation of the other residues , including Tyr 397 , in rate and extent , ( 2 ) alphaIIbbeta 3 independent phosphorylation of Tyr 925 and Tyr 397 , and ( 3 ) complex formation between FAK and the Src kinase Fgr but not with c Src . ^^^ |
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| Interacting proteins: P09769 and Q05397 |
Pubmed |
SVM Score :0.0 |
| Full length , membrane bound Fgr , but not an N terminal truncation mutant that distributed to an intracellular compartment , increased cell migration on fibronectin and enhanced phosphorylation of the p 85 subunit of phosphatidylinositol 3 kinase ( PI3K ) , cortactin and focal adhesion kinase ( FAK ) at Y 397 and Y 576 . ^^^ Fgr increased Rac GTP loading , and phosphorylation of the Rac GEF Vav 2 , and bound to a protein complex formed by the Rho inhibitor p190RhoGAP and FAK , increasing p190RhoGAP phosphorylation , in a manner absolutely dependent on membrane localization . ^^^ A kinase defective truncation mutant of Fgr increased cell migration , albeit to a much lower extent than full length Fgr , and was found to associate with the plasma membrane , to activate Rac and to form complexes with p190RhoGAP / FAK . ^^^ Formation of complexes between p190RhoGAP , Fgr , and the FAK related protein Pyk 2 were also detected in murine macrophages . ^^^ These findings suggest that the proto oncogene Fgr regulates cell migration impinging on a signaling pathway implicating FAK / Pyk2 and leading to activation of Rac and the Rho inhibitor p190RhoGAP . . ^^^ |
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| Interacting proteins: P09769 and Q05397 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and Q05397 |
Pubmed |
SVM Score :0.0 |
| NA |
|