| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| Virus has been isolated from 15 PML brains , and preliminary studies indicate that one isolate , while clearly of JCV type , is serologically distinguishable from prototype Mad 1 JCV . . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| Sequencing of the JCV regulatory region from the lymphocytes of three patients revealed the prototype MAD 1 strain of JCV in one patient with PML , a MAD 4 strain in a second patient with PML , and a slightly modified MAD 4 strain in an HIV 1 positive patient without PML . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| A newly isolated virus from a patient with progressive multifocal leukoencephalopathy ( PML ) ( Tokyo 1 strain ) was found serologically identical to JC virus ( Mad 1 strain ) and showed high neurooncogenicity in hamsters . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| In the present study we examined the infectivity of archetypal JCV ( CY ) , PML type JCV ( Mad 1 ) and Chimera JCV ( Mad 1 / CR CY ) , in which the regulatory region is composed of CY and the other region Mad 1 . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| The TCR of the major variant JCV W 1 was comparable in sequence and structure to that of the PML prototype JCV Mad 1 DNA . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| The prototype Mad 1 variant of JCV induces a fatal demyelinating disease of the central nervous system ( CNS ) called Progressive Multifocal Leukoencephalopathy ( PML ) in immunosuppressed individuals . ^^^ The archetype form of this virus , JCV ( CY ) , which has been repeatedly isolated from the urine of PML and non PML individuals , is distinct from JCV ( Mad 1 ) in the structural organization of the regulatory sequence . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| In keeping with the role of PML in transcriptional repression , pRB also promoted PML dependent transcriptional repression by the c Myc antagonist Mad 1 . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| However the rearranged forms , whose prototype is Mad 1 , possibly generated by deletion and duplication of segments of the archetype sequence , are found in the brain and cerebrospinal fluid ( CSF ) of PML patients . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| Growth occurred more slowly and to lower titers than is seen with the prototypical PML JCV strain Mad 1 , with relatively few cells containing viral T antigen ( T Ag ) or viral capsid protein , Vp 1 . ^^^ The amount of GS / K DNA was also greatly enhanced when it was cotransfected with Mad 1 JCV DNA , the prototypical PML isolate . ^^^ Archetype JCV can be successfully propagated in HFB cells , although infection develops much more slowly than that caused by the PML JCV variant Mad 1 . ^^^ |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05195 and P29590 |
Pubmed |
SVM Score :0.0 |
| NA |
|