Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
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Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
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Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
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Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.60328704
The saturation binding of P [ 125I ] MBA in T47D cells as studied by Scatchard analysis showed saturable binding , with a Kd = 94 + / 7 nM and a Bmax = 2035 + / 305 fmol / mg of proteins . 0.60328704^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.54342608
The only preoperative parameter ( of the LVM formula ) that was different between AR and AS patients was the left ventricular end diastolic diameter ( 68 + / 11 mm vs . 51 + / 7 mm , respectively , P < 0 . 05 ) . 0.54342608^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.74394133
In this study we show that E 6 AP interacts with androgen receptor ( AR ) in a hormone dependent manner and enhances the transactivation function of AR . 0.74394133^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
On a series of 170 aortic valve replacement 100 aortic stenoses ( AS ) and 70 aortic regurgitations ( AR ) with an early post operative death rate of 5 . 3 % and a late one of 8 % ( with a minimum follow up of 1 year and an average one of 25 . 4 months , two electrocardiographic and radiological checks could be done on 123 patients , 12 months on an average after the operation , and again for 116 patients , 21 months after the operation . ^^^ The decrease of LVH ( Sokolow ' s index and AVL ) tended to be more marked for the AS group and that of HA for the AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
There were nine patients with aortic stenosis ( AS ) , ten patients with combined stenosis and regurgitation ( AS AR ) , and five patients with aortic regurgitation ( AR ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
However , the performance of the color Doppler method in patients with AR accompanying aortic stenosis ( AS ) has not been studied . ^^^ We therefore compared results of color Doppler and semiquantitative angiographic grading of AR in 32 patients with AS ( mean valve area = 0 . 7 cm 2 ) undergoing supravalvular aortography in the course of cardiac catheterization . ^^^ Thus , color Doppler sensitively depicts AR in patients with AS , and the ratio of JH to LVOT height by color Doppler correctly identifies patients with III+ or IV+ AR by aortography . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The 85 kd subunit ( p 85 alpha ) lacks Pl 3 kinase activity and acts as an adaptor , coupling the 110 kd subunit ( p 110 ) to activated protein tyrosine kinases . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
To elucidate the aging changes of human aortic valves and their relation to aortic regurgitation ( AR ) or stenosis ( AS ) , consecutive echocardiographic examinations in 1601 subjects were carried out . ^^^ The incidence of TAV and the associated AS and AR tended to increase with age . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
This was independent of IR and AR as the rate of movement in Bismark cultivar was markedly slower than that in Omega and Spunta ( IR AR ) , Delaware ( 1 ( S ) AR ) , and Desiree and Renova ( 1 ( S ) A ( S ) ) cultivars . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Age and sex ar not significantly associated with AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In this study 13 patients with aortic stenosis ( AS ) and 19 patients with aortic regurgitation ( AR ) were analyzed to investigate the correlation between myocardial structure and left ventricular ( LV ) function . ^^^ AR group : EM score in AR was significantly higher than that in AS ( p < 0 . 05 ) . ^^^ The above mentioned results indicated that preoperative LVMI and the morphologic parameters were useful to predict the reversibility of the postoperative LV function in both AS and AR . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
It is concluded that an MBP peptide specific disease can be induced in three different haplotypes and it is possible that shared structures between the As , Aq and Ar molecules are of importance for the trigger of encephalitogenic T cells with different TcR 5 elements . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
QRST area departure maps were constructed from electrocardiographic ( ECG ) data recorded in patients with LVH and precordial negative T waves resulting from aortic stenosis ( AS ) ( 10 patients ) , aortic regurgitation ( AR ) ( 12 patients ) , or hypertrophic cardiomyopathy ( HCM ) with asymmetric septal hypertrophy ( 22 patients ) . ^^^ Patients with large LV masses due to AS or AR had 2 SD areas located over the left anterior chest or the midanterior chest , respectively . ^^^ The sum of QRST area values less than the normal range ( sigma QRST ) was significantly correlated with LV mass in patients with AS or AR ( r = 0 . 83 and r = 0 . 69 , p less than 0 . 01 and p less than 0 . 05 ) . ^^^ However , there was no significant correlation between sigma QRST and the severity of LVH in patients with HCM . sigma QRST divided by the number of electrodes in the 2 SD area was significantly greater in patients with HCM than in those with AS or AR . ^^^ QRST isointegral departure maps may provide ECG evidence of LV mass of patients with AS or AR and of susceptibility to malignant arrhythmias in patients with HCM . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In the present study , to assess the two types of hypertrophied myocardium we investigated the 44 patients undergoing valve replacement ; the 23 patients of aortic stenosis ( AS ) without aortic regurgitation ( AR ) , and the 21 patients of AR without AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
We have studied the response of EOS isolated from the blood of atopic subjects with symptoms of asthma ( AS , n = 7 ) or rhinitis ( AR , n = 4 ) or without symptoms ( AA , n = 5 ) and of subjects with the hypereosinophilic syndrome ( HES , n = 5 ) . ^^^ Normodense EOS from AS ( PAF induced CL = 90 + / 27 mV ) were more responsive to PAF than were those from AR ( 17 + / 13 mV , p less than 0 . 01 ) and from AA ( 23 + / 14 mV , p less than 0 . 01 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
It was low in most of AR , being the erythroid population the most affected in AS and the granulocytic one in AREB and AREB T . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Pre and postoperative left ventricular ( LV ) mass and myocardial contractile state were evaluated in 62 patients with aortic regurgitation ( AR ) and in 20 patients with aortic stenosis ( AS ) . ^^^ Preoperatively , there was a significant inverse correlation between LV mass and end systolic wall stress ( ESS ) / end systolic volume index in AR patients and AS patients . ^^^ Our results indicated that myocardial function was irreversible even in postoperative unloading conditions , when preoperative LV mass exceeded 250 g / m2 in AR patients as well as AS patients . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Among 240 patients who had undergone aortic valve replacement ( AVR ) including combined valvular diseases up to March 1989 , the congenitally bicuspid aortic valve was responsible for AR and stenosis ( AS ) in 33 patients ( 13 . 8 % ) and were divided according to the presence of a raphe . ^^^ Rest of the patients exhibited severe AS due to the calcification of cusps except a case who showed IE with AR in the calcified cusp . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Especially evident was the high prevalence of IgA antibodies to a 60 kD antigen among patients with ReA ( 67 % ) compared with patients with AS ( 20 % ) . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Preparation of red cell or saliva specific ABH antibodies To prepare agglutinins specific for red cell ( anti Hr , Ar and Br ) or for saliva ( anti Hs , As and Bs ) , many animals were immunized with red cell or saliva . ^^^ By these procedures , specific anti Hr , Ar , Hs , As and Hs were prepared . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The relation between preoperative left ventricular ( LV ) systolic function at rest and postoperative LV response to exercise was assessed in 13 patients with aortic regurgitation ( AR ) and nine patients with aortic stenosis ( AS ) . ^^^ Our study demonstrated that preoperative LV systolic function in AR and AS patients closely reflected postoperative LV response to exercise . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Eleven were normal ( N ) , 14 had aortic stenosis ( AS ) and 16 had aortic regurgitation ( AR ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
To investigate the relation of left ventricular ( LV ) afterload , hypertrophy , geometry and systolic pump function , 17 normal persons , 24 patients with aortic stenosis ( AS ) , 20 with aortic regurgitation ( AR ) and 15 with idiopathic dilated cardiomyopathy ( DC ) were studied . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Therefore , 25 patients with angiographically documented severe AR and peak systolic aortic velocities of greater than 2 . 5 m / s were studied by continuous wave Doppler to determine the accuracy of pressure gradient and aortic valve area calculations in assessing the severity of aortic stenosis ( AS ) in this patient population . ^^^ Thus , the continuity equation provides a reliable estimate of aortic valve area in patients with severe AR and should be used to evaluate the extent of AS in such patients when high systolic aortic velocities are present . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The initial lesion was aortic stenosis ( AS ) in 40 p . cent , aortic regurgitation ( AR ) in 35 p . cent and aortic disease ( AD ) in 25 p . cent of the cases . ^^^ Peri operative mortality ( up to 30 days ) was 7 . 09 p . cent in both the 1974 79 period and the 1980 86 period ; it was 3 . 4 p . cent in AS , 7 . 4 p . cent in AD and 10 . 7 p . cent in AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
This study was consisted of 69 patients undergoing aortic valve replacement for chronic aortic regurgitation ( AR ) and 29 patients , for aortic stenosis ( AS ) between 1978 and 1985 . ^^^ In conclusion , minimal preoperative left ventricular function for satisfactory late results and reversal of functional results may be at a lower level was LVESVI 200 ml / m2 in AR patients and 100 ml / m2 in AS patients . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Fifty six patients with volume overloaded hearts ( 27 with AR , 24 with MR , and 4 with AR and MR ) and 10 patients with AS were examined . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
They included 204 cases ( 45 % ) of aortic regurgitation ( AR ) , 171 cases ( 37 % ) of mitral regurgitation ( MR ) , followed by 45 ( 10 % ) of aortic stenosis ( AS ) and 27 cases ( 6 % ) of mitral stenosis ( MS ) . ^^^ The clinical characteristics in cases with valvular diseases were as follows : atrial fibrillation was prominent in MS ; congestive heart failure was found in 60 % of cases except those with degenerative AR ; cardiac death was frequent in syphilitic and rheumatic AR ; association of hypertension was found in 50 % of cases with MR and degenerative AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Ampicillin susceptible ( AS ) and ampicillin resistant ( AR ) challenge strains were employed . ^^^ Treatment with enoxacin or ofloxacin produced intrapulmonary killing of H . influenzae that was superior to that achieved with ampicillin ( P less than 0 . 01 to P less than 0 . 001 for both AS and AR strains ) . ^^^ We conclude that enoxacin and ofloxacin may be effective antimicrobial agents in treating either AS or AR strains causing H . influenzae pneumonia . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
An ampicillin sensitive ( AS ) and an ampicillin resistant ( AR ) challenge strain were employed . ^^^ Ciprofloxacin treatment produced intrapulmonary killing of H . influenzae which was superior to that achieved with ampicillin ( P less than 0 . 001 , both strains ) and chloramphenicol ( P less than 0 . 001 , strain AS ; P less than 0 . 005 , strain AR ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
A 70 kD component and several low molecular weight components ( Mr 19 kD and 14 kD ( doublet ] were detectable only in CIC from patients with AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Frame by frame analysis of stress ( sigma ) and volume ( 5 ) was performed for two differently loaded beats in 26 patients who underwent simultaneous cineangiography and micromanometry : nine normal subjects , eight with isolated aortic regurgitation ( AR ) , and nine with aortic stenosis ( AS ) . ^^^ MaxEav was preserved in the AR group ( 1575 + / 565 ) and increased in the AS group ( 1877 + / 544 ; p = . 02 ) compared with normal ( 1320 + / 268 ) , suggesting maintenance of contractile force per unit of myocardium in these two lesions . ^^^ However , theoretical `` unloaded ' ' shortening fraction ( SFo ) was depressed in the AS group ( 0 . 30 + / 0 . 06 ; p = . 01 ) compared with normal ( 0 . 37 + / 0 . 04 ) , preserved in the AR group ( 0 . 34 + / 0 . 07 ; p = . 24 ) , and inversely related to maxEav ( r = . 66 , p = . 01 ) , suggesting a disparity between shortening potential and force potential . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
A primary pigment in the microvillous structure , AR , or in organelles in the Semper cells , AS , is converted by UV light into an excited state AR * or AS * , which either relaxes to the primary pigment by photon emission , or converts into an intermediate 10 , which by proton uptake changes into stable products , BR or BS . ^^^ Blue illumination converts BR and BS into the excited states BR * and BS * , which either relax by photon emission to BR or BS , or convert into an intermediate Y , which after deprotonation reconverts into the primary pigment AR or AS . 5 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In the present study , the effects of nomegestrol acetate and other antiandrogens on the binding of androgen to the androgen receptor ( AR ) and on the ' activation ' of this receptor were investigated , using rat ventral prostate as target model . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Twenty three cases with aortic regurgitation ( AR ) and 20 cases with aortic stenosis ( AS ) were selected by postoperative period over 12 months . ^^^ In 18 AR cases with normal coronary artery substantiated by selective coronary angiography , cross sectional area index of left ventricular wall ( CSAI ) and ST depression in left chest leads of electrocardiogram correlated well as the CSAI increased , so decreased the ST segment . ^^^ By means of introduction of this indicator , 23 AR and 20 AS patients were divided into two groups as group C 1 having CSAI over 20 cm2 / m2 and group C 2 under 20 cm2 / m2 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The AS lyase monomer in control fibroblasts was present in two bands of approximately 51 and approximately 49 Kd . ^^^ The approximately 51 Kd band was found in only six mutants with near normal amounts of AS lyase CRM or high residual enzyme activity . ^^^ The residual AS lyase enzyme activity in a mutant did not necessarily reflect the amount of the 49 51 Kd monomer in that strain . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
While accommodative stimulus ( AS ) is slowly changed over a wide range with a constant velocity ( 0 . 2 D s 1 ) , accommodative response ( AR ) is continuously measured . ^^^ AS and AR , respectively , are recorded on the abscissa and the ordinate of an 10 y recorder to produce a `` quasi static ' ' response / stimulus curve . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
After partial purification by 35 % ammonium sulfate precipitation ( AS cytosol ) , the binding specificity pattern was consistent with that of androgen receptor . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Ia . 22 can be generated by the complementation of Ab , Ak , As , Ar , with Ed , Ek , Ep , Er , Ew 3 , Eu , Ev but Eb , Ef , Eq , and Es . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Echocardiographic LV mass was then compared with RE and SL in an unselected clinical series of 100 subjects , in 28 subjects with severe aortic stenosis ( AS ) and in 14 with severe aortic regurgitation ( AR ) . ^^^ In the AS and AR groups , with a high prevalence of LVH , the low sensitivity of RE point score and Sl criteria led to poor overall results . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The operation was done because of aortic stenosis ( AS ) in 14 patients and aortic regurgitation ( AR ) in 19 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Frequency and grade of ventricular arrhythmias in patients with isolated aortic stenosis ( AS ) or regurgitation ( AR ) were determined by 24 hour ambulatory electrocardiographic monitoring . ^^^ Among patients with AS or AR , arrhythmia occurrence and grade of ventricular ectopic activity were not related to the degree of AS or AR , ventricular hemodynamics or the presence or absence of concomitant CAD . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Microsomes prepared from the brachial artery and the thoracic aorta of atherosclerosis resistant ( AR ) Show Racer and atherosclerosis prone ( AS ) White Carneau pigeons were incubated with 14C prostaglandin endoperoxide ( PGH ) and prostaglandin products analyzed . ^^^ Reduced glutathione enhanced PGE 2 formation in both the AR and AS preparations identifying an active PGH PGE isomerase . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Doppler echocardiographically measured maxPG at rest was 31 + / 16 mmHg , which showed no significant difference from the differences in patients ' diseases ( aortic regurgitation = AR or stenosis = AS ) , or BSA . ^^^ These results indicate that , following the implantation of SJM 19 , LV hypertrophy was reduced in patients with AR as well as with AS , when their BSA values were less than 1 . 6 m 2 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
To determine resting myocardial perfusion in 30 patients with aortic valve disease ( AVD ) TI 201 emission computer tomography ( ECT ) studies and heart catheterization were performed . 16 patients had a predominant aortic regurgitation ( AR ) ; an aortic stenosis ( AS ) was found in 14 patients at catheterization . ^^^ Perfusion defects were documented in 10 of 16 patients with AR , and in 5 of 14 patients with AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Indications for operation included : aortic stenosis ( AS ) 15 patients , aortic regurgitation ( AR ) 24 , and mixed 11 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
We examined 26 patients with chronic aortic regurgitation ( AR ) , 12 patients with predominant aortic stenosis ( AS ) , and 11 control subjects using an intravascular Doppler catheter with spectral analysis . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The substrate dATP binds tightly to peptide 1 under these conditions ( KD = 0 . 5 microM ) as determined by fluorescence quenching but induces no change in peptide conformation , as detected by CD spectroscopy . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Five different enzymes , carbamyl phosphate synthetase 1 ( CPS 1 ) , ornithine transcarbamylase ( OTC ) argininosuccinate synthetase ( AS ) , argininosuccinate lyase ( AL ) and arginase ( AR ) play a role in urea synthesis from ammonium . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
This property might be attributed to a reversal of biaryl configuration from the normal aS to aR . ^^^ Therefore , the N aroyl analogs were further evaluated by circular dichroism , which readily distinguishes between the aS and aR biaryl configurations . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The configuration of the parent alcohol ( compound 5 ) was established unequivocally as ( aR , 6S ) by 10 ray crystallographic analysis . ^^^ To explain the strong antitubulin activity of compound 5 ( with an aR configured biaryl system in contrast to the aS configuration previously described for colchicinoids , allocolchicinoids , and steganacin ) we speculate that a rapid atropisomerism equilibrium must exist for 5 and its active derivatives . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Transmural LV free wall homogenates from DIAB exhibited similar beta AR density as CON , but decreased cAMP production ( pmol cAMP / mg prot . min ) using these pharmacological stimulators : 10 microM Isoproterenol plus 100 microM GTP ( 74 + / 5 5 97 + / 11 ) ; 100 microM Gpp ( NH ) p ( 116 + / 7 5 161 + / 17 ) ; 10 mM fluoride ion ( 266 + / 16 5 324 + / 25 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Infection : ( 1 ) increased right ventricular ( RV ) beta adrenergic receptor ( beta AR ) density five fold ; ( 2 ) decreased left ventricle beta AR density by 20 % ; ( 3 ) reduced the proportion of high affinity beta AR receptors to the same extent in both left and right ventricles ; ( 4 ) reduced alpha s by 50 % as determined by Western blot analysis , increased alpha 11 3 but did not change alpha 0 ; and ( 5 ) decreased the magnitude of pertussis toxin dependent [ 32P ] ADP ribosylation by 60 % as well as the proportion of [ 32P ] ADP ribose incorporated in alpha 0 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Both the time of external pipping ( ep ) and hatching of embryos from the ascites resistant ( AR ) broiler line was earlier compared to the ascites sensitive line ( AS ) . ^^^ The T 3 and T 4 concentrations in plasma of the AS line were lower compared to the AR line . 4 . ^^^ Analyses of partial pressures of oxygen ( pO 2 ) and carbon dioxide ( pCO 2 ) in the air cell of the egg revealed that at day 18 the AS embryos had lower pO 2 and higher pCO 2 concentrations compared to the AR embryos . 5 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In all cases , optically pure isomers with the ( ) aS , 7S configuration exhibited greater biological activity than racemic mixtures or isomers or isomers with the ( + ) aR , 7R configuration . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Three hundred and thirty five patients were included in a prospective study : 78 had MR , 57 had AR , 150 had AS and 50 had MS . ^^^ The quantification of the valvular disease was concordant for groups 1 and 2 in 93 , 97 , 98 . 5 and 100 % for MR , AR , AS and MS respectively . ^^^ The theoretical management decision was concordant between the two groups for 97 % of MR , 94 . 7 % of AR , 95 . 3 % of AS and 94 % of MS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In this paper , we report studies on prospective probiotic effects of Bifidobacterium longum NCFB 2259 in relation to other bacterial populations , production of tyrosine and phenylalanine metabolites , and bacterial synthesis of enzymes involved in the formation of putatively genotoxic metabolites , including beta glucosidase ( GS ) , arylsulphatase ( AS ) , beta glucuronidase ( GN ) , nitroreductase ( NR ) and azoreductase ( AR ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Our objective was to assess myocardial reflectivity pattern of patients with severe left ventricular hypertrophy caused by either aortic stenosis ( AS ) or aortic regurgitation ( AR ) . ^^^ Ten patients with AS , 10 patients with AR , and 10 closely age and gender matched healthy controls were studied by two dimensional Doppler echocardiography . ^^^ All patients with stenosis or aortic insufficiency showed a normal regional and global resting systolic function ( fractional shortening : AS = 36 . 0 + / 6 . 6 versus AR = 40 . 3 + / 6 . 2 versus control = 40 . 2 + / 8 . 7 ; p = not significant [ NS ] ) Left ventricular mass index ( Devereux ' s formula ) was markedly increased in patients with stenosis or aortic insufficiency ( AS = 199 . 3 + / 18 versus AR = 208 . 8 + / 60 versus control = 97 . 3 + / 11 g / m2 ; p < 0 . 0001 ) . ^^^ Myocardial echo density was increased in patients with stenosis or aortic insufficiency in comparison with controls , both in the septum ( IBI % : AR = 40 . 7 + / 7 . 9 versus AS = 33 . 4 + / 4 . 2 versus control = 23 . 0 + / 6 . 2 ; p < 0 . 0001 ) and in the posterior wall ( IBI % : AR = 27 . 1 + / 4 . 3 versus AS = 23 . 0 + / 2 . 6 versus control = 15 . 0 + / 4 . 2 ; p < 0 . 0001 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
OBJECTIVES : We attempted to determine whether inflammation is present in induced sputum of patients with seasonal allergic rhinitis ( AR ) as compared with those with perennial asthma ( AS ) and examined its relationship with bronchial responsiveness to methacholine . ^^^ RESULTS : We found that the number of eosinophils in the AS group was greater than that in the AR+ group ( p < 0 . 05 ) and in the AR group ( p < 0 . 01 ) . ^^^ Similarly , the number of EG2+ cells was greater in the AS group than in the AR group ( p < 0 . 02 ) and the AR group ( p < 0 . 05 ) . ^^^ The number of mast cells and basophils in the AS group was greater than that in the AR group ( p < 0 . 05 and p < 0 . 01 , respectively ) . ^^^ Our findings are consistent with the hypothesis that eosinophils , as well as mast cells , contribute to bronchial responsiveness not only in AS but also in seasonal AR . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
G alpha 16 proteins were revealed in myeloid cells as two bands ( 43 and 46 kD ) , implying that G alpha 16 exist in short and long forms . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
We have demonstrated that anti sense phosphorothioate oligodeoxynucleotides ( AS S oligos ) directed against the EGF like growth factors CRIPTO ( CR ) , amphiregulin ( AR ) or transforming growth factor alpha ( TGFalpha ) mRNA , are equipotent in their ability to inhibit the growth of human colon carcinoma GEO cells . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In the anabolic steroid ( AS ) treated horses , but not in the controls ( C ) , the cross sectional area of the type 1 fibres increased significantly during the treatment period , and the percentage of type IIA fibres correlated positively with AR concentration at the end of nandrolone treatment . ^^^ It can thus be concluded that AS produce differing effects on type 1 and type 2 fibres , and the AR concentration in equine muscle may contribute to the change observed in the middle gluteal muscle . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Main etiology of their diseases is calcific AS 7 ( 4 : bicuspid valve ) , degenerative AR 4 , rheumatic AS / AR 5 , AAE 2 , MR due to MVP or chordal rupture 13 , rheumatic MS / MR 13 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
As a result of earlier surgical referral , however , fewer patients with aortic regurgitation ( AR ) and advanced LV failure present for operation today . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Fusion of the beta 2 AR to Gs alpha promotes efficient coupling as shown by high affinity agonist binding and GTPase and adenylyl cyclase activation and ensures fixed stoichiometry between receptor and G protein . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Preoperative diagnosis revealed aortic regurgitation ( AR ) in 25 cases , aortic stenosis ( AS ) in ten , combined AS and AR in nine and LVOTO in two patients . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The experiments were carried out during continuous recording of tracheal pressure ( Ptr ) , airflow ( 5 ) and tidal volume ( VT ) signals variations evidencing respiratory asynchronism ( AS ) and allowing measurements of the changes in airway resistance ( AR ) and dynamic compliance ( Cdyn ) during all the challenge . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Among the four isomers of 3 , the ( aR , S ) enantiomer ( 3a A ) exhibited the most potent antagonistic activities with an IC 50 value of 0 . 80 nM ( in vitro inhibition of [ 125I ] BH SP binding in human IM 9 cells ) and ED 50 values of 9 . 3 micrograms / kg ( 4 ) and 67 . 7 micrograms / kg ( po ) ( in vivo inhibition of capsaicin induced plasma extravasation in guinea pig trachea ) , while the activity of the ( aS , R ) enantiomer ( 3b B ) was the weakest with an IC 50 value of 620 nM . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
RESULTS : Thirty two patients demonstrated aortic stenosis ( AS ) , 27 aortic regurgitation ( AR ) , and four had both conditions . ^^^ Patients with AR were significantly younger than those with AS ( 45 + / 13 versus 60 + / 11 years ; p < 0 . 01 ) . ^^^ Twenty one patients ( 55 % ) in the former group demonstrated AR , whereas 19 ( 76 % ) in the latter group demonstrated AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Antisense 20 mer phosphorothioate oligodeoxynucleotides ( AS S oligos ) directed against CR , AR , and TGF alpha mRNAs were equipotent in their ability to inhibit both the anchorage dependent growth and the anchorage independent growth ( AIG ) of GEO cells , with a 50 % inhibitory concentration of about 5 micrometer in the AIG assay . ^^^ For example , a combination of two different AS S oligos ( either AR + CR , or TGF alpha + CR , or TGF alpha + AR ) at a concentration of 1 micrometer each ( total concentration , 2 micrometer ) resulted in 50 % inhibition of GEO cells AIG , whereas the use of each AS S Oligo at a 1 or 2 micrometer concentration resulted respectively in about 10 and 20 % growth inhibition . ^^^ The AS S oligos were also able to inhibit specifically the expression of either AR , CR , or TGF alpha proteins in GEO cells , as assessed using immunocytochemistry or Western blot analysis . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Several hydrolytic and reductive bacterial enzymes ( beta glucuronidase , GN ; beta glucosidase , GS ; arylsulphatase , AS ; azoreductase , AR ; nitroreductase , NR ) involved in production of mutagenic or genotoxic metabolites were measured in human colonic contents . ^^^ Cell associated AS and extracellular GS were approximately twice as high in the distal colon compared with the proximal bowel , while AR changed little throughout the gut . ^^^ All five clostridia studied ( Clostridium bifermentans , C . septicum , C . perfringens , C . sporogenes and C . butyricum ) produced NR and AR , as did the bacteroides ( B . fragilis , B . ovatus and B . vulgatus ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Treatment with the AR AS S oligo also resulted in a significant inhibition of MDA MB 468 anchorage dependent growth ( ADG ) . ^^^ The AS S oligos inhibited the expression of AR , CR or TGF alpha proteins and mRNAs , as assessed by immuno cytochemistry and semi quantitative RT PCR . ^^^ Indeed , treatment of MDA MB 468 cells with a combination of AR , CR and TGF alpha AS S oligos resulted in about 70 % growth inhibition at a concentration of 0 . 7 microM each . ^^^ Finally , treatment of MDA MB 468 cells with a combination either of the 3 AS S oligos or of an EGF receptor blocking antibody ( MAb 225 ) and either CR , AR or TGFalpha AS S oligos resulted in a significant increase in DNA fragmentation . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Patients were divided into four groups : aortic regurgitation ( AR ) , aortic stenosis ( AS ) , mitral regurgitation ( MR ) and mitral stenosis ( MS ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The percentages of motile sperm ( % MO ) , hyperactivated sperm ( % HA ) , and acrosome reacted sperm ( % AR ) of four beagle dogs with asthenozoospermia ( AS ) and five normal beagle dogs were determined during 7 h of incubation . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
O ' Donnell CP , Schaub CD , Haines AS , Berkowitz DE , Tankersley CG , Schwartz AR , Smith PL . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
RESULTS : At the time of mitral valve surgery , 59 patients ( 45 % ) had mild aortic valve disease : 7 ( 5 % ) aortic stenosis ( AS ) , 58 ( 44 % ) aortic regurgitation ( AR ) . ^^^ At the end of follow up , 96 patients ( 73 % ) had aortic valve disease : 33 AS ( mild or moderate except in two cases ) and 90 AR ( mild or moderate except in one case ) . ^^^ Disease progression was noted in three of the seven patients with AS ( 2 to severe ) and in six of the fifty eight with AR ( 1 to severe ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Significantly , the in vitro activity of ( aR , 9R ) 8b was ca . 750 fold higher than that of its enantiomer ( aS , 9S ) 8b , ca . 40 fold higher than its atropisomer ( aS , 9R ) 8b , and ca . 20 fold higher than its diastereomer ( aR , 9S ) 8b . ^^^ Compound ( aR , 9R ) 8b has been identified as a potential clinical candidate for the treatment of bladder function disorders . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The preoperative diagnosis was aortic stenosis ( AS ; n = 66 ) , aortic regurgitation ( AR ; n = 19 ) or AS / AR ( n = 8 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Rigid body docking simulations between the different forms of the alpha 1 b AR and the heterotrimeric G alpha q , G alpha s , G alpha i 1 , and G alpha t suggest that the cytosolic crevice shared by the active receptor and including the second and the third intracellular loops as well as the cytosolic extension of helices 5 and 6 , represents the receptor surface with docking complementarity with the G protein . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Three clones , selected by hygromycin B , expressed AR antisense RNA ( AR AS 1 , AR AS 2 and AR AS 3 cell lines ) in which AR protein expression was reduced ( ranging from about 50 to < 5 % ) . ^^^ The anchorage independent growth of AR AS cell lines was reduced to levels ranging from 32 . 4 6 . 8 % relative to the control cell line transfected with the vector alone . ^^^ Moreover , intra tumoral vascularization decreased significantly in tumors derived from AR AS cells ( 26 . 7 , 70 . 7 and 50 . 4 % of control ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
For aortic stenosis ( AS ) , valvotomy may be preferred to replacement wherever feasible and for aortic regurgitation ( AR ) repair is not yet well established . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Haemodynamic indication for AVR was aortic regurgitation ( AR ) in 24 ( 42 . 8 % ) , aortic stenosis ( AS ) in 22 ( 39 . 2 % ) and mixed disease in ten ( 17 . 8 % ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Aortic valve etiology was as follows , AS : 1 case , AR : 2 cases , ASR : 3 cases , IE : 1 case , mechanical valve malfunction due to subvalvular pannus : 1 case . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The antiproliferative effects of antisense phosphorothioate oligodeoxynucleotides ( AS S Oligos ) directed against either AR , CR or TGFalpha was evaluated by using a clonogenic assay . ^^^ AS S Oligos directed against either AR , CR or TGFalpha were able to inhibit the anchorage independent growth of NIH : OVCAR 3 and NIH : OVCAR 8 cells in a dose dependent manner . ^^^ A 60 % 75 % growth inhibition was observed using combinations of AR , CR and TGFalpha AS S oligos at a total concentration of 2 microM . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Androgen receptor blockade by flutamide also decreased the prostatic levels of alpha ( s , ) alpha ( i1 / 2 ) , and alpha ( i3 / 0 ) G protein subunits , as estimated by an immunological procedure . ^^^ Thus , androgen receptor blockade by flutamide results in an important impairment of the components of the VIP receptor / effector system in rat prostate as well as in a modification of their coupling extent , which is presumably due to differences observed in plasma membrane fluidity . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
OBJECTIVE : In view of a possible role of androgens in the pathogenesis of ankylosing spondylitis ( AS ) , we investigated the association between Japanese male patients with AS and CAG microsatellites of the androgen receptor ( AR ) gene which related to the AR transactivation function . ^^^ CONCLUSIONS : Shorter CAG repeats of the AR gene , presenting high levels of transactivation activity , may play a role in male AS . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Participants with AR had larger aortic root diameters ( 3 . 6+ / 0 . 4 vs . 3 . 4+ / 0 . 4 cm , p < 0 . 001 ) , higher creatinine levels ( 1 . 3+ / 1 . 3 vs . 1 . 0+ / 1 . 0 mg / dl , p < 0 . 001 ) and higher urine albumin / creatinine levels ( 3 . 6+ / 2 . 3 vs . 3 . 3+ / 2 . 0 log , p < 0 . 001 ) , as well as higher prevalences of aortic stenosis ( AS ) or mitral stenosis ( MS ) ( p < 0 . 001 ) . ^^^ Regression analysis showed that AR was independently related to older age and larger aortic roots ( p < 0 . 0001 ) , AS and absence of diabetes ( p = 0 . 002 ) , MS ( p = 0 . 003 ) and higher log urine albumin / creatinine ( p = 0 . 005 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Its polygraphic features involve progressive increases in esophageal pressure ( Pes ) , terminated by arousal ( AR ) as defined by the American Sleep Disorders Association ( ASDA ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Within very specific chemical environments , metolachlor atropisomers aS , 12S ( aR , 12R ) and aR , 12S ( aS , 12R ) freely interchange , and consequently , the multiple conformations also interchange . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
METHODS : The level of EXCH transcription was analyzed in myocardial biopsies from eleven patients with aortic stenosis ( AS ) , five with aortic regurgitation ( AR ) and six with primary mitral regurgitation ( MR ) of different hemodynamic severity and myocardial impairment using the quantitative rt PCR technique . ^^^ RESULTS : The mean level of EXCH transcription in patients with AS was : 1 . 8 + / 1 . 4 amol / ng total RNA , with AR : 1 . 9 + / 0 . 8 amol / ng and with MR : 2 . 2 + / +2 . 1 amol / ng . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
A biochemical characterization was then carried out on the 70 % AS supernatants by ultrafiltration on 30 and 50 kD cut off membranes and by sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS PAGE ) . ^^^ SDS PAGE of 70 % AS supernatants revealed a protein of 23 kD that was more concentrated in AS supernatants from FSGS plasma than the other plasma samples and that was identified by microsequencing as apolipoprotein A 1 . ^^^ After sequential ultrafiltration of 70 % AS supernatants on 30 and 50 kD cut off membranes , a second band of 43 kD was found at a much higher concentration in the FSGS samples than in non FSGS NS and healthy individuals samples . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In this study , we analyzed the extent and pattern of regression of left ventricular ( LV ) hypertrophy after aortic valve replacement in patients with aortic stenosis ( AS ) and compared the results with those of another group of patients with aortic regurgitation ( AR ) . ^^^ After aortic valve replacement , the wall thickness remained significantly greater than normal for patients with AS , and the chamber radius remained significantly greater than normal for patients with AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Cognition 1994 ; 50 : 7 15 ) and those with peripheral neuropathy ( Bechara A , Tranel D , Wilson J , Heberlein AS , Ross M , Damasio AR , 1998 . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
RESULTS : Protein , ACE and TGF beta 1 mRNA were significantly increased in patients with AS and AR ( 1 . 5 to 2 . 1 fold ) and correlated with each other . ^^^ Collagen 1 and 3 and fibronectin mRNAs were both upregulated about twofold in patients with AS and AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Possible coupling of alpha ( 2A ) AR to endogenous G ( alphai / o ) proteins in CHO K 1 cells was excluded by measuring pertussis toxin ( PTX ) resistant [ ( 35 ) S ] GTPgammaS binding responses as a common functional response to alpha ( 2A ) AR activation . ( ) Adrenaline ( 10 microM ) displayed the highest magnitude of [ ( 35 ) S ] GTPgammaS binding response in the co presence of a PTX resistant G ( alphao ) Cys ( 351 ) Ile protein , whereas a decreased response was obtained with the mutant G ( alphai1 / 2 ) proteins . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Because some properties of native GPCRs are disadvantageous for ectopic therapeutic expression , we utilized the beta ( 2 ) adrenergic receptor ( beta ( 2 ) AR ) as a scaffold to construct a highly modified therapeutic receptor effector complex ( TREC ) suitable for gene therapy . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
While sodium hydride mediated intramolecular amination of ( 4S , aS ) 4 alkyl 4 [ N ( arylsulfonyl ) amino ] 1 bromobuta 1 , 2 dienes yields a mixture of 2 , 3 cis and 2 , 3 trans 2 ethynylaziridines in which the cis isomer predominates ( 79 : 21 89 : 11 ) , the amination of ( 4S , aR ) isomers affords 2 , 3 cis aziridines in excellent selectivities ( 91 : 9 100 : 0 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Resolution of the enantiomers of ( + / ) econazole , ( + / ) miconazole , and ( + / ) sulconazole has been achieved on different normal phase chiral amylose columns , Chi ralpak AD , AS , and AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Recombinant A ( 1 ) and A ( 3 ) adenosine receptors couple well to G ( i / o ) , but recombinant human A ( 2A ) adenosine receptors ( hA ( 2A ) AR ) couple poorly to G ( s ) and bind agonists with K ( 1 ) values in binding assays that are much higher than ED ( 50 ) values for functional responses such as coronary dilation and inhibition of neutrophil oxidative burst . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Although certain genes , such as SOD or hemoxygenase and antisense to AT ( 1 ) R , ACE , and ( beta ( 1 ) AR can provide short term protection of the heart from ischemia , there is no known mechanism for constantly responding to repeated incidences of ischemia . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Based on the type of valvular dysfunction , patients were classified into 2 groups : 141 patients with aortic stenosis ( group AS ) and 42 patients with pure aortic regurgitation ( group AR ) . ^^^ Both LA size and LA ejection force were significantly greater in group AS than group AR , particularly in patients with a concentric LV pattern . ^^^ The degree of LA enlargement depended on LV mass in the patients with a concentric LV pattern ( group AS r = 0 . 61 , p < 0 . 00001 ; group AR r = 0 . 38 , p = 0 . 04 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The patients were divided into three groups : patients with ascending aortic replacement ( group AS , n = 41 ) , those with hemiarch replacement ( group HA , n = 23 ) , and those with transverse arch replacement ( group AR , n = 24 ) . ^^^ In hospital mortality in groups AS , HA , and AR were 7 . 3 % , 8 . 6 % , and 33 . 3 % , respectively ( p = 0 . 011 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The transition structures for cis aziridine formation of both ( 4S , aR ) and ( 4S , aS ) bromoallenes in DMF are favored over the corresponding trans transition structures by 4 . 35 and 1 . 41 kcal / mol , respectively . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
This report proposes a beta ( 3 ) adrenoceptor ( AR ) selective agonist , 2 [ 2 chloro 4 ( 2 ( [ ( 1S , 2R ) 2 hydroxy 2 ( 4 hydroxyphenyl ) 1 methylethyl ] amino ) ethyl ) phenoxy ] acetic acid ( 1a ) , as a novel agent for treating urinary bladder dysfunction . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The results showed that As in rice seed was mainly combined with the proteins with apparent molecular weights of 54 . 5 KD and 5 . 5 KD . ^^^ The protein binding form of As ( 54 . 5 KD ) was unstable , and was easily decomposed into stable and tiny molecular under the treatment of steaming and digestive enzyme . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The current studies were designed to explore the effect of prolonged inhibition of central alpha ( 2B ) AR gene expression by antisense ( AS ) DNA on this hypertension . ^^^ METHODS : We developed a plasmid vector driven by a cytomegalovirus promoter , containing a green fluorescent protein reporter gene and AS for rat alpha ( 2B ) AR protein . ^^^ Subtotally nephrectomized , salt loaded hypertensive rats received intracerebroventricular injection of 500 microg of either the AS plasmid ( n = 9 ) or sense plasmid ( containing cDNA for alpha ( 2B ) AR ) , as control ( n = 7 ) . ^^^ CONCLUSIONS : These results indicate that protracted translational inhibition of the alpha ( 2B ) AR gene in the central nervous system can be obtained by AS DNA delivered via plasmid vector and lead to decreased generation of alpha ( 2B ) AR protein , which can partly reverse salt induced hypertension for several days . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
OBJECTIVE : Aortic valve replacement for aortic valve stenosis ( AS ) and regurgitation ( AR ) in patients with severe left ventricular ( LV ) dysfunction contains an increased risk . ^^^ METHODS : Fifty five consecutive patients with severe LV dysfunction ( ejection fraction , EF ; < 30 % ) and aortic valve replacement for AS ( n=35 ) or AR ( n=20 ) were investigated between 1994 and 2001 . ^^^ RESULTS : The survival rates for AS were : 1 year 76 % , 2 year 68 . 8 % , 5 year 64 . 2 % ; for AR : 1 year 94 . 4 % , 2 year 86 . 5 % , 5 year 74 . 2 % . ^^^ NYHA functional class improved from 90 % in class III / IV to 45 ( AR group ) and 24 % ( AS group ) at follow up ( P < 0 . 02 ) . ^^^ The EF improved to 38+ / 4 ( AR group ) and 40+ / 5 % ( AS group ) at follow up . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Therefore , we designed this study to investigate the overall effect of multiple IEAS on appearance of asthma ( AS ) , allergic rhinitis ( AR ) , and eczema ( EC ) symptoms in 1472 primary school children . ^^^ The association of IEAS and AR increased stepwise as more IEAS appeared in the environment ( 1 . 71 , 2 . 47 , to 2 . 86 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
BACKGROUND : Patients with bicuspid aortic valve ( BAV ) have been frequently complicated with ascending aortic dilation possibly because of hemodynamic burdens by aortic stenosis ( AS ) or regurgitation ( AR ) or congenital fragility of the aortic wall . ^^^ METHODS AND RESULTS : To clarify if the aortic dilation could be prevented by aortic valve replacement ( AVR ) in BAV patients , we studied 13 BAV ( 8 AR dominant , 5 AS dominant ) and 14 tricuspid aortic valve ( TAV ) patients ( 7 AR , 7 AS ) by echocardiography before and after AVR ( 9 . 7+ / 4 . 8 years ) . ^^^ We also studied 18 BAV ( 11 AR , 7 AS ) without AVR . ^^^ AR dominant group showed tendency of more progressive dilation than AS dominant group in BAV , although it did not reach statistical significance . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The established standard ketone hydrogenation ( abbreviated HY herein ) precatalyst [ Ru ( Cl ) ( 2 ) ( ( S ) tolbinap ) [ ( S , S ) dpen ] ] ( ( S ) , ( S , S ) 1 ) has turned out also to be a precatalyst for ketone transfer hydrogenation ( abbreviated TRHY herein ) as tested on the substrate acetophenone ( 3 ) in iPrOH under standard conditions ( 45 degrees C , 45 bar H ( 2 ) or Ar at atmospheric pressure ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
METHODS : Patients with chronic pressure overload due to aortic stenosis ( AS , n = 19 ) and chronic volume overload due to either aortic regurgitation ( AR , n = 9 ) or mitral regurgitation ( MR , n = 10 ) were examined . ^^^ RESULTS : The amount of interstitial cardiac fibrosis ( ICF ) was significantly higher in AS ( 5 . 7 + / 4 . 1 g / m2 ) , AR ( 8 . 8 + / 4 . 9 g / m2 ) or MR ( 4 . 7 + / 2 . 8 g / m2 ) than in controls ( 2 . 3 + / 1 . 5 g / m2 ) ( p = 0 . 003 ) . ^^^ The amount of thick collagen fibers was higher in AR than in AS , where by density of fibroblasts did not differ . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
At the beginning of PD therapy the older patients showed higher total fat mass ( TFM ) expressed as % of total body mass ( TBM ) , lower lean body mass ( LBM ) , lower serum levels of iron , phosphorus and creatinine as well as lower transferrin saturation . ^^^ When mean values representing the entire PD course were compared , the older patients showed higher TFM as % of TBM and serum ferritin level , whereas lower values were observed for diastolic blood pressure ( DBP ) , LBM , serum creatinine , phosphorus and iron . ^^^ At the end of PD therapy TFM as % of TBM and serum ferritin level remained higher in older patients as well as lower both DBP and LBM were maintained . ^^^ In conclusion , the older patients reach similar PD outcome parameters compared to the younger ones while they show higher TFM as % of TBM , stable RRF and more satisfactory DBP . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Primary dynamics predisposing to the onset of chronic spinal disorders , e . g . , adolescent idiopathic scoliosis ( AIS ) or ankylosing spondylitis ( AS ) , must clearly be differentiated from secondary alterations . ^^^ The hypothesis postulates opposing inherent muscle tonicity in AIS versus AS . ^^^ Converse degrees of spinal stability may predispose to the respective curvature deformities of AIS and the enthesopathy lesions of AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Postoperative long term changes in LV indices were investigated in patients with asymptomatic aortic regurgitation ( AR ) and symptomatic aortic stenosis ( AS ) and related to alleles of ACE polymorphisms . ^^^ METHODS : A total of 96 patients was included in the study , 21 with class IIa AR ( 22 % ) and 75 with class 1 AS ( 78 % ) recommendations for surgery . ^^^ CONCLUSION : AR patients showed a statistically significant decrease in absolute / indexed LVMM during follow up , but never achieved LV mass recovery compared to standard values or to values in patients undergoing aortic valve replacement for AS . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The objectives of the present study were to determine if the nature of allergenic exposition to animal , plant or fungal allergens influenced the clinical manifestations of atopic dermatitis ( AD ) , allergic rhinitis ( AR ) or asthma ( AS ) in patients living in a tropical environment . ^^^ SUBJECTS AND METHODS : A total of 1496 atopic cases , grouped according to the primary diagnosis of AD or AR or AS , were skin tested using a standardized allergen panel . ^^^ Of these , 38 . 4 % had AD , 31 . 3 % had AR and 30 . 5 % with AS . ^^^ CONCLUSION : These data demonstrate that for patients with AD , AR and AS living in a tropical environment , the prevalence of positive skin reactions to animal allergens is highest followed by plant and fungal allergens . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
METHODS : Thirty rats were randomly divided into allergic rhinitis group ( AR ) , asthma group ( AS ) , and control group ( Con ) . ^^^ RESULTS : The numbers of eosinophils and mast cells in nasal mucosa and lung tissue of AR were both significantly higher than those of Con , and similar results were observed between AS and Con . ^^^ The forced expiratory volume in 0 . 3 second ( FEV0 . 3 ) / forced vital capacity ( FVC ) of AR and AS was both significantly lower than that of Con . ^^^ The numbers of VCAM 1 and IL 13 positive vessels in lung tissue of AR were both significantly higher than those of Con , and similar results were observed between AS and Con . ^^^ The concentration of IL 5 in the serum of AR and AS was both significantly higher than that of Con . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Effects of dissolved carbonate on arsenate [ As ( 5 ) ] reactivity and surface speciation at the hematite water interface were studied as a function of pH and two different partial pressures of carbon dioxide gas [ P ( CO 2 ) = 10 ( 3 . 5 ) atm and approximately 0 ; CO 2 free argon ( Ar ) ] using adsorption kinetics , pseudo equilibrium adsorption / titration experiments , extended 10 ray absorption fine structure spectroscopic ( EXAFS ) analyses , and surface complexation modeling . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
METHODS : Fifty one patients with valve disease underwent single valve surgery ( mitral stenosis , MS , 13 ; mitral regurgitation , MR , 16 ; aortic stenosis , AS , 14 ; aortic regurgitation , AR , 8 patients ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
During a 9 year period from January 1965 through December 1973 , we performed isolated aortic valve replacement ( AVR ) for aortic stenosis ( AS ) or aortic regurgitation ( AR ) in 165 patients . ^^^ The 1 year survival rate was 91 % for patients with AS and 71 % for those with AR ( p < 0 . 05 ) . ^^^ These results indicate that , in both AS and AR patients , operation should be performed early , before severely limiting symptoms and signs arise . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Nevertheless , probing the physiological changes in adrenoceptor function in rodent obesity , as well as the process by which beta ( 3 ) AR agonists promote a thermogenic shift in fuel use , have yielded unexpected new insights into beta AR signaling and adipocyte physiology . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Aortic stenosis ( AS ) can be evaluated with the same modalities as AR . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
By preoperative echocardiographic and macroscopic studies , they were classified into functional disorders of predominant aortic stenosis ( AS ) , aortic stenosis with regurgitation ( AS AR ) and predominant aortic regurgitation ( AR ) . ^^^ RESULTS : Among 110 AV ( 76 isolated AV and 34 with concomitant mitral valves from patients aged 15 96 years , mean age 47 . 54 years ; male : female = 1 . 39 : 1 ) there were 25 AS ( 22 . 73 % ) , 34 AS AR ( 30 . 91 % ) and 51 AR ( 46 . 36 % ) cases . ^^^ In AS AR , 29 cases ( 85 . 29 % ; mean age 47 . 10 years ; male : female = 1 . 23 : 1 ) were attributable to postinflammatory disease and 5 cases ( mean age 70 . 20 years ; male : female = 1 . 5 : 1 ) to degenerative calcific change . ^^^ Four of 18 postinflammatory AS AR and 4 of 14 postinflammatory disease AR cases had past history of rheumatic fever . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
After that , five dentures of each denture base material were repaired with one of the four following techniques : L ( Lucitone 199 , water bath , 8 h / 74 degrees C , gypsum mould ) , A ( Acron MC , microwave , 3 min / 500 W , gypsum mould ) , AR ( Acron MC / R , autopolymerized , 60 psi / 45 degrees C / 15 min ) and the experimental technique AS ( Acron MC , 1 min / 500 W + 1 min / 0 W + 1 min / 500 W , hard silicone mould ) . ^^^ Analysis of variance ( SuperANOVA ) and means compared by Tukey Kramer intervals ( 0 . 05 ) revealed that AR repair had the best percentage difference value for DA [ 0 . 5 % ( P < 0 . 05 ) ] , while the others were not statistically different [ L = 27 . 2 % , A = 28 . 9 % , AS = 21 . 2 % ( P > 0 . 05 ) ] . ^^^ For HC , there was a statistical difference ( P < 0 . 05 ) between AR and the other techniques for the tooth pairs , 16 26 , 11 26 and 21 16 ; repairs with AR and AS differed for the 11 21 pair , while those with A and AS techniques differed for the 16 26 pair ( P < 0 . 05 ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Pure aortic stenosis ( AS ) was present in 32 % of patients , pure aortic regurgitation ( AR ) in 22 % and mixed disease in the rest . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Main valvular lesion of BAV was aortic valve stenosis ( AS ) in 17 and regurgitation ( AR ) in 9 . ^^^ There was no significant difference in the aortic annular size between BAV and non BAV cases measured by echocardiography preoperatively [ 22 . 8 + / 2 . 0 mm versus 22 . 5 + / 2 . 2 mm in AS ( NS ) , and 25 . 4 + / 2 . 4 mm versus 23 . 4 + / 2 . 5 mm in AR ( NS ) ] . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
INTRODUCTION : It is not clear whether associated aortic regurgitation ( AR ) should be regarded as a risk factor in patients undergoing surgery for severe aortic stenosis ( AS ) . ^^^ OBJECTIVE : This study made an attempt to compare the outcome and prognosis following the surgical intervention in patients with severe AS and associated AR and those operated for pure AS , as well as to determine predictive value of clinical , functional and echocardiographic data for the outcome of surgery . ^^^ The patients were divided into AS group ( 63 patients with AS without AR or with mild AR ) and AS+AR group ( 59 patients with AS and moderate , severe or very severe AR ) . ^^^ Multivariate analysis found the association of more than mild AR as an independent predictor of poor functional capacity , irrespective of its severity . ^^^ CONCLUSION : Patients with severe AS and associated AR have poorer postoperative functional capacity as compared to patients operated for pure AS . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Reintervention for residual / recurrent AS or iatrogenic AR is relatively common , particularly during the first year after BAVP , but aortic valve replacement during early childhood is seldom necessary . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
AIMS : Recently an elevation of B type natriuretic peptide ( BNP ) and its N terminal fragment ( NT proBNP ) in patients with aortic stenosis ( AS ) and aortic regurgitation ( AR ) has been described . ^^^ NT proBNP was elevated in patients with AS ( n=109 ) and AR ( n=37 ) linked to disease severity . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Of these patients , 12 had aortic regurgitation ( AR ) , 31 had aortic stenosis ( AS ) , and 12 had mixed disease . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
METHODS AND RESULTS : Histological analysis of pathological valves [ aortic stenosis ( AS ) ( n=49 ) , aortic regurgitation ( AR ) ( n=23 ) ] and control valves ( n=8 ) was performed . ^^^ The main tissue abnormalities ( calcification , inflammatory cells , and capillaries ) observed in AS were less severe or absent in AR . ^^^ CONCLUSION : This study demonstrates the involvement of the MMP / TIMP system in ECM remodelling of both AS and AR . ^^^ These findings provide evidence of inflammatory injury more severe in AS than in AR and involvement of mesenchymal cell response . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
An arsenate reductase ( AR ) in the fern showed a reaction mechanism similar to the previously reported Acr2p , an AR from yeast ( Saccharomyces cerevisiae ) , using glutathione as the electron donor . ^^^ Substrate specificity as well as sensitivity toward inhibitors for the fern AR ( phosphate as a competitive inhibitor , arsenite as a noncompetitive inhibitor ) was also similar to Acr2p . ^^^ These results indicate that ( 1 ) arsenite , the previously reported main storage form of As in the fern fronds , may come mainly from the reduction of arsenate in roots ; and ( 2 ) AR plays an important role in the detoxification of As in the As hyperaccumulating fern . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
PATIENTS AND METHOD : There were 28 patients ( 12 men and 16 women ) , 12 AR , 15 AS and 1 unknown . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Geometrical and electronic structures of dinuclear complex ions { ( mu bpym ) [ Cu ( EAr 3 ) 2 ] 2 } 2+ with intramolecular `` organic sandwich ' ' formation ( E = P or As ; Ar = Aryl ; bpym = 2 , 2 ' bipyrimidine ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
This report describes 5 cases that demonstrate how the Blanked Flutter Search algorithm can be activated in the absence of atrial tachycardia , atrial flutter , or sinus tachycardia by a single atrial event ( AR ) detected in the atrial refractory period of the pacemaker provided it is either preceded or followed by a sensed atrial event ( AS ) . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The aim of the present study was to investigate whether patients with AR and asthma differed from AR with or without BHR in degree of perception of dyspnoea and airway inflammation , measured as fractionated exhaled nitric oxide ( NO ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Fifty seven per cent of the participants were classified as AR , 39 % as UR and 4 % as over reporters with the PFD . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The valve pathology was aortic stenosis ( AS ) in 79 % , aortic regurgitation ( AR ) in 12 % , and mixed in 9 % . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
We found that patients serum reacted : 1 ) against larval As antigens with a molecular weight ( mw ) of 25 kilodalton ( kD ) and a mw > than 100 kD , 2 ) against various metabolic As antigens with a mw > than 100 kD , a mw ranging approximately from 35 to 50 kD , and a mw around 20 kD , and 3 ) against Dp proteins with mw between 35 and 55 kD . ^^^ Preincubation of patient ' s serum with Dp extract caused the disappearance of reactivity against antigens with a mw > than 100 kD in both larval and metabolic As extracts and against proteins with mw ranging approximately from 35 to 50 kD in the metabolic As extract . ^^^ Preincubation of patients serum with As extract caused the disappearance of reactivity against antigens with mw between 35 and 55 kD in the Dp extract . ^^^ The results show that 1 ) cross reactive components between Dp and As are some proteins with a mw ranging approximately from 35 to 50 kD and with a mw > than 100 kD , and 2 ) tr is not involved in cross reactivity between As and Dp . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
In the present study the possible interaction of AV tissue with platelet aggregation was examined , using fragments of AV obtained from patients with AS and aortic regurgitation ( AR ) . ^^^ The direct effects of valve tissue from patients with AS ( n = 14 ) or with predominant AR ( n = 13 ) on ADP induced platelet aggregation and intraplatelet cGMP and cAMP content were compared . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : We used the Gregorc Style Delineator to measure participants ' perceptual and ordering abilities , combining them in a quaternary design to create mean composite scores for the Concrete Sequential ( CS ) , Abstract Sequential ( AS ) , Abstract Random ( AR ) , and Concrete Random ( CR ) Mind Styles subscales . ^^^ Program directors preferred the CS style more ( P < . 001 ) and the AS and AR styles less ( P < . 001 ) than predicted by chi ( 2 ) testing . ^^^ Men students preferred the AS style more ( P < . 01 ) and the AR style less ( P < . 01 ) than women students . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Multiple and paradoxical effects of airway smooth muscle ( ASM ) 7 transmembrane spanning receptors activated during asthma , or by treatment with bronchodilators such as beta ( 2 ) adrenergic receptor ( beta ( 2 ) AR ) agonists , indicate extensive receptor crosstalk . ^^^ Thus alone , EP ( 1 ) does not appear to have a significant direct effect on airway tone but acts as a modulator of the beta ( 2 ) AR , altering G ( alphas ) coupling via steric interactions imposed by the EP ( 1 ) : beta ( 2 ) AR heterodimeric signaling complex and ultimately affecting beta ( 2 ) AR mediated bronchial relaxation . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
Here we demonstrate that a subpopulation of L type Ca ( 2+ ) channels is localized to caveolae in ventricular myocytes as part of a macromolecular signaling complex necessary for beta ( 2 ) adrenergic receptor ( AR ) regulation of 1 ( Ca , L ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
The HPV E 6 oncoprotein binds to a cellular protein of 100 kd , termed E 6 associated protein ( E 6 AP ) . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
We demonstrated that the expression of E 6 AP protein is decreased in human invasive breast and prostate carcinomas compared with their adjacent normal tissues , and this down regulation of E 6 AP is accompanied by the up regulation of estrogen receptor ( ER ) alpha in breast and androgen receptor ( AR ) in prostate carcinomas . ^^^ Furthermore , our in vivo data from E 6 AP knockout animals indicated that the expression levels of ERalpha and AR are increased in E 6 AP null mammary and prostate glands , respectively , when compared with that of normal control animals , suggesting that E 6 AP modulates the protein levels of ERalpha in breast and AR in prostate glands . . ^^^
Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
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Interacting proteins: Q05086 and P10275 Pubmed SVM Score :0.0
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