| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.81394876 |
| These findings indicate that interactions between the AR , SRY , and DAX 1 contribute to normal male development and function and suggest a general role for protein protein interactions between high mobility group box proteins and steroid hormone receptors in regulating tissue specific gene expression . . 0.81394876^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.74262069 |
| Here , we show that the single HMGB 1 domains A and B , the HMG box domain of sex determination factor SRY , as well as the prokaryotic HMGB 1 like protein HU , specifically interact with hcDNA ( Kd approximately 0 . 5 nM ) . 0.74262069^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| We first describe the basis of sexual determination and differentiation , and then we analyze the different roles of SRY gene , encoding for the testis determining factor , androgen receptor gene , 5 alpha reductase gene and anti Mllerian hormone gene . . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| Recent developments in molecular biology have provided the opportunity to analyze the gene responsible for testicular determination , SRY , the androgen receptor gene and the gene encoding the cP 450 enzyme specific for 21 hydroxylation , CYP21B , whose defects are responsible for congenital adrenal hyperplasia . ^^^ Southern blotting studies and PCR analyses of SRY , androgen receptor and CYP21B genes can be routinely used for the direct diagnosis of gonadal dysgenesis , androgen insensitivity syndromes and congenital adrenal hyperplasia , respectively . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| Normal endocrinological findings and exclusion of mutations in SRY , androgen receptor and alpha reductase genes point to supplementary gene ( s ) located in 9p2305 ter , haplo insufficiency ( by deletion ) of which is expected to cause defective male morphogenesis . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| We have amplified by polymerase chain reaction ( PCR ) five polymorphic markers along the 10 chromosome ( DXS1283E , DYS 2 , DMD 49 , AR and DXS 52 ) and three markers along the Y chromosome ( SRY , DYZ 3 and DYZ 1 ) . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| METHODS : Genomic DNA from leukocytes was isolated in order to analyze SRY gene by PCR and sequencing of the eight exons of AR gene . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| DNA extracted from 81 lavage and the corresponding placental samples was amplified by a polymerase chain reaction ( PCR ) assay using primers for SRY and HUMARA genes . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| Description and molecular analysis of SRY and AR genes in a patient with 46 , XY pure gonadal dysgenesis ( Swyer syndrome ) . 46 , XY pure gonadal dysgenesis , first described in 1955 by Swyer , results from testicular tissue loss during the first 8 weeks of fetal life , a critical period for male differentiation . ^^^ A molecular investigation was undertaken in an attempt to determine mutations in SRY and AR genes through DNA sequencing . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| During fetal development , SRY , SOX 9 , WT 1 , SRD5A2 and AR are important at different stages in the differentiation and development of the male genital system . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| The cloning of the gene responsible for testicular determination SRY , of the anti Mllerian hormone and anti Mllerian hormone receptor genes , of the several steroidogenic enzymes genes , of the 5 alpha reductase type 2 gene and of the androgen receptor gene has permitted to elucidate the molecular defects causing abnormal sexual differentiation . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| Coding sequences of the sex determining gene ( SRY ) and androgen receptor gene ( AR ) were found to be identical to those of a normal male excluding their role in the cause of the present condition . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| These include the discovery of a number of genes ( SRY , WT 1 , SF 1 , SOX 9 ) and one locus ( DSS ) involved in human gonadal differentiation , and understanding gained from extensive studies of the androgen receptor and its gene . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| The Wilms ' tumor gene WT 1 can regulate genes involved in sex determination and differentiation : SRY , Mllerian inhibiting substance , and the androgen receptor . ^^^ |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| One set of sense / antisense primers is used to amplify the experimental transgene ( androgen receptor gene in this case ) , the second set for the mouse Y chromosome specific SRY gene , and the third set for the beta subunit of the thyroid stimulating hormone ( TSH beta ) , an internal control . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| The PCR assay for fetal sex determination was performed by using , in a multiplex reaction , primers for SRY ( Y chromosome sex determining region , 738 bp ) and HUMARA ( human androgen receptor on the 10 chromosome , 280 bp ) genes . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| The 60 normal individuals in the study were correctly typed to their phenotypic sex by the 2 PCR methods used , i . e . , the single PCR using the amelogenin sequence specific for the 10 and Y chromosomes and the multiplex PCR using SRY gene ( male specific ) and the AR gene ( 10 specific ) . ^^^ |
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| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| TDF neither competed for binding to D 2 , D 3 or D 4 DA receptors nor altered the Kd or the Bmax of [ 3H ] SCH 23390 and [ 3H ] spiperone recognition sites associated with striatal D 1 and D 2 receptors , respectively . ^^^ |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q05066 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|