| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Activation of hepatocyte growth factor by two homologous proteases , blood coagulation factor XIIa and hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| It has been reported that thrombin activates the zymogen of hepatocyte growth factor activator [ Shimomura , T . , Kondo , J . , Ochiai , M . , Naka , D . , Miyazawa , K . , Morimoto , Y . & Kitamura , N . ( 1993 ) J . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Activation of the zymogen of hepatocyte growth factor activator by thrombin . ^^^ Hepatocyte growth factor activator ( HGF activator ) is a serine protease which converts single chain HGF to the active two chain form . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Database searches revealed a 50 63 % similarity and 34 42 % identity with several families of serine proteases , in particular the trypsin like proteases , members of the glandular kallikrein family ( including prostate specific antigen , nerve growth factor gamma , and epidermal growth factor binding protein ) and the activators for the kringle family proteins ( including the human tissue plasminogen activator and human hepatocyte growth factor activator ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Purification and characterization of a novel hyaluronan binding protein ( PHBP ) from human plasma : it has three EGF , a kringle and a serine protease domain , similar to hepatocyte growth factor activator . ^^^ The amino acid sequence deduced from the nucleotide sequence of the cloned PHBP cDNA exhibited significant homology to that of hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation . ^^^ Hepatocyte growth factor activator ( HGFA ) is a serine protease that is responsible for localized activation of hepatocyte growth factor ( HGF ) in injured tissue . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor , a novel Kunitz type serine protease inhibitor . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| This conversion was accompanied by increased gene expression of hepatocyte growth factor activator in the stomach . ^^^ In rats with acute mucosal lesions , hepatocyte growth factor activator mRNA was most abundant 6 h after induction of mucosal lesions . ^^^ On the other hand , hepatocyte growth factor and hepatocyte growth factor activator mRNA levels were elevated until 15 days after the induction of chronic ulcers . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Astroglial expression of hepatocyte growth factor and hepatocyte growth factor activator in human brain tissues . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Purification and cloning of hepatocyte growth factor activator inhibitor type 2 , a Kunitz type serine protease inhibitor . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Like human PHBP , the amino acid sequence predicted from the nucleotide sequence of mouse PHBP cDNA exhibited significant homology to that of human hepatocyte growth factor activator ( HGFA ) . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| PHBP is a novel human plasma hyaluronan binding protein that shows significant homology in amino acid sequence to hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa . ^^^ Gene expression of hepatocyte growth factor activator inhibitor ( HAI ) , a recently identified Kunitz type serine proteinase inhibitor , was analyzed in a series of human colorectal carcinoma cell lines and in human colorectal tissues . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2 . ^^^ Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was identified as a potent inhibitor of hepatocyte growth factor activator ( HGF activator ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene phylogenetic and functional relationship with blood coagulation factor 12 , urokinase , and tissue type plasminogen activator . ^^^ The organization and structure of the gene coding for hepatocyte growth factor activator ( HGFA ) have been determined by isolation of unique clones from a human genomic library . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator : a possible regulator of morphogenesis during fetal development of the rat gastrointestinal tract . ^^^ The role played by the hepatocyte growth factor activator ( HGFA ) during morphogenesis of the gastrointestinal tract was investigated in fetal rats between days 16 and 21 of gestation . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz type serine proteinase inhibitor domain is a predominant product in mouse but not in human . ^^^ Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a new Kunitz type serine protease inhibitor , which is purified and cloned from human stomach cancer cell line MKN 45 . ^^^ The mature HAI 2 protein contains two Kunitz domains and the first domain is mainly responsible for the inhibitory activity against hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Distribution of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in human tissues . ^^^ We used a specific monoclonal antibody to human hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in immunohistochemical procedures to determine the distribution and localization of HAI 1 in human tissues . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Amino acid sequences obtained from the matriptase associated proteins reveal that they are fragments of a Kunitz type serine protease inhibitor that was previously reported to be an inhibitor of the hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The messenger RNA ( mRNA ) for CYP2E1 , cytokeratin , ubiquitin , hepatocyte growth factor activator , and tissue transglutaminase was quantitated . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Conserved expression of hepatocyte growth factor activator inhibitor type 2 / placental bikunin in human colorectal carcinomas . ^^^ Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was recently identified as a potent inhibitor of hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Mouse hepatocyte growth factor activator gene : its expression not only in the liver but also in the gastrointestinal tract . ^^^ A cDNA encoding mouse hepatocyte growth factor activator ( HGFA ) has been cloned by RT PCR , based on the screening result from the database of expressed sequence tags . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator ( HGF A ) and its zymogen in human placenta . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator ( HGFA ) and regulates HGFA activity in the pericellular microenvironment . ^^^ Hepatocyte growth factor activator ( HGFA ) is responsible for proteolytic activation of the precursor form of hepatocyte growth factor in injured tissues . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans ' cells of human placenta . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Plasma hyaluronan biding protein ( PHBP ) is a novel serine protease , which has an amino acid sequence homology to that of hepatocyte growth factor activator ( HGFA ) , and has a similar domain structure to that of urinary plasminogen activator ( u PA ) , found in human plasma . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| We now show that the complexed matriptase is an activated , two chain form , which is inhibited in an acid sensitive , reversible manner through binding to its cognate , Kunitz type inhibitor , HAI 1 ( hepatocyte growth factor activator inhibitor 1 ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Mouse hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) / placental bikunin genes and their promoters . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor , which was identified as a potent inhibitor of hepatocyte growth factor ( HGF ) activator from the conditioned medium of a human carcinoma cell line . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| This serine protease revealed partial structural homology with a ' hepatocyte growth factor activator ' . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The crystal structure of the MT SP 1 complex with bovine pancreatic trypsin inhibitor serves as a model for hepatocyte growth factor activator inhibitor 1 , the physiological inhibitor of MT SP 1 , and suggests determinants for the substrate specificity . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , a Kunitz type serine protease inhibitor for hepatocyte growth factor activator ( HGFA ) , is responsible for proteolytic activation of hepatocyte growth factor . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a serine proteinase inhibitor containing two Kunitz type inhibitor domains , initially identified as a potent inhibitor of hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1 . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor ( HGF ) activator and matriptase . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to examine the expression of matriptase , and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , in epithelial ovarian cancer and to assign clinicopathological correlations . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Ribosomal protein S 3 was underexpressed only in squamous cell carcinomas , whereas expression of hepatocyte growth factor activator inhibitor type 2 , ubiquitin conjugating enzyme UBC 9 , and clone 333E23 on chromosome Xq21 . 1 were altered only in adenocarcinomas . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Expression of a hepatocyte growth factor activator protein in turkey ( Meleagris gallopavo ) deferent duct epithelial cells . ^^^ NCBI BLAST searches within the GenBank database returned 63 . 5 and 61 . 7 % identity with murine and human hepatocyte growth factor activator ( HGFA ) precursor , respectively . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor in gingival crevicular fluid and the distribution of hepatocyte growth factor activator in gingival tissue from adult periodontitis . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Identification of hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) : its nuclear localization and generation of chimeric mRNA transcribed from both HAI 2 and H2RSP genes . ^^^ A novel small gene , designated hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) was cloned and characterized in the process of the search for splicing variant forms of HAI 2 by 3 ' rapid amplification of cDNA ends ( RACE ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| To determine whether these factors contribute to the distinct etiologies of fibrolamellar hepatocellular carcinoma and traditional hepatocellular carcinoma , we assayed hepatocyte growth factor , the hepatocyte growth factor receptor , and two hepatocyte growth factor activators , hepatocyte growth factor activator and urokinase type plasminogen activator , in hepatocellular carcinoma , fibrolamellar hepatocellular carcinoma , cirrhotic liver and normal liver . ^^^ Western blot analyses using antibodies against hepatocyte growth factor , hepatocyte growth factor receptor , phosphotyrosine , hepatocyte growth factor activator , urokinase type plasminogen activator receptor , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen and plasmin were performed on membrane enriched fractions from the frozen tissue , as was collagen zymography for matrix metalloproteinase 2 and matrix metalloproteinase 9 . ^^^ The most notable findings are as follows : hepatocyte growth factor activator was only detected in malignant tissue but not cirrhotic liver or normal liver . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) in human testis : identification of a distinct transcription start site for the HAI 2 gene in testis . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently identified integral membrane Kunitz type proteinase inhibitors . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Roles of hepatocyte growth factor activator ( HGFA ) and its inhibitor HAI 1 in the regeneration of injured gastrointestinal mucosa . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Characterization of transcripts generated from mouse hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) and HAI 2 related small peptide ( H2RSP ) genes : chimeric mRNA transcribed from both HAI 2 and H2RSP genes is detected in human but not in mouse . ^^^ We previously reported a novel small gene , designated hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) , in the process of the search for splicing variant forms of HAI 2 by 3 ( ' ) rapid amplification of cDNA ends method [ Biochem . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Tissue microarray analysis of hepatocyte growth factor / Met pathway components reveals a role for Met , matriptase , and hepatocyte growth factor activator inhibitor 1 in the progression of node negative breast cancer . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The method is based on positive immunoselection using an antibody ( mAb C76 / 18 ) reacting with hepatocyte growth factor activator inhibitor 1 , HAI 1 , a membrane antigen on villous cytotrophoblast . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 , may also participate in the activation of matriptase , based on the observation that matriptase activation did not occur when the protease was co expressed with hepatocyte growth factor activator inhibitor 1 mutated in its low density lipoprotein receptor class A domain . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor types 1 and 2 are expressed by tubular epithelium in kidney and down regulated in renal cell carcinoma . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Genes demonstrating differential expression were confirmed by quantitative PCR ( Q PCR ) and include cytochrome P 450 1A ( CYP1A ) , a putative hepatocyte growth factor activator , a 10 ray inducible retrotransposon , and several expressed sequenced tags ( ESTs ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence of PHBP is homologous to that of hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in cancer cells at the invasion front . ^^^ We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth factor activator ( HGFA ) and matriptase , in colorectal adenocarcinomas . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator deficient mice . ^^^ BACKGROUND AND AIMS : Hepatocyte growth factor activator ( HGFA ) is a serum proteinase that specifically converts an inactive single chain form of hepatocyte growth factor ( HGF ) into an active 2 chain form . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| There are increasing data that suggest a role for the serine protease matriptase and its inhibitor , hepatocyte growth factor activator inhibitor 1 , in the pathogenesis and progression of ovarian cancer . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Tissue expression , protease specificity , and Kunitz domain functions of hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) , a new splice variant of HAI 1 . ^^^ Hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) is an integral membrane protein expressed on epithelial cells and contains two extracellular Kunitz domains ( N terminal KD 1 and C terminal KD 2 ) known to inhibit trypsin like serine proteases . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of hepatocyte growth factor activator ( HGFA ) in developing mouse liver tissues . ^^^ Hepatocyte growth factor activator ( HGFA ) can activate the single chain hepatocyte growth factor ( HGF ) required for embryonic development . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 / placental bikunin ( HAI 2 / PB ) is a serine proteinase inhibitor that has a broad inhibitory spectra against various serine proteinases . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor 2 / placental bikunin ( HAI 2 / PB ) gene is frequently hypermethylated in human hepatocellular carcinoma . ^^^ Among these genes , the hepatocyte growth factor activator inhibitor 2 / placental bikunin ( HAI 2 / PB ) gene was maximally induced by 5 Aza CdR in three of six cell lines studied ( HLE , HuH 7 , and Hep3B ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepsin activates pro hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) and HAI 2 . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) was initially identified as cognate inhibitor of matriptase , a membrane bound serine protease . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Previous microarray analysis demonstrated that 14 genes , including hepatocyte growth factor activator inhibitor 2 / placental bikunin ( HAI2 / PB ) gene , showed particularly high inductions after 5 aza 2 ' deoxycytidine ( 5Aza dC ) treatment in multiple hepatoma cell lines . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2 / SPINT2 in papillary and clear cell renal cell carcinoma . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Simultaneous activation and hepatocyte growth factor activator inhibitor 1 mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells . ^^^ Activation of single chain , latent matriptase , a type 2 transmembrane serine protease , depends on the weak proteolytic activity of its own zymogen as well as its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| A total of 804 distinct plasma proteins ( not including immunoglobulins ) were confidently identified with 32 proteins observed to be significantly increased in concentration following LPS administration , including several known inflammatory response or acute phase mediators such as C reactive protein , serum amyloid A and A 2 , LPS binding protein , LPS responsive and beige like anchor protein , hepatocyte growth factor activator , and von Willebrand factor , and thus , constituting potential biomarkers for inflammatory response . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Using COS 1 monkey kidney cells transiently transfected with rat MT SP1 / matriptase expression plasmids , we found that the enzyme is post translationally processed by the cleavage between Gly 149 and Ser 150 , that a portion of the C terminal part ( Ser 150 Val855 ) remains in the cells by association with the NTF ( N terminal fragment ) ( Met 1 Gly149 ) , while the other portions are released into the medium and that the release is increased on activation by co expression with hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Conformational lability in serine protease active sites : structures of hepatocyte growth factor activator ( HGFA ) alone and with the inhibitory domain from HGFA inhibitor 1B . ^^^ Hepatocyte growth factor activator ( HGFA ) is a serine protease that converts hepatocyte growth factor ( HGF ) into its active form . ^^^ In order to find whether this apparently non enzymatically competent arrangement would persist in the presence of a strongly interacting inhibitor , we also have determined , at 2 . 6 A resolution , the 10 ray structure of HGFA complexed with the first Kunitz domain ( KD 1 ) from the physiological inhibitor hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor activator ( HGFA ) is the principal activator of HGF . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Serum hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) in prostate cancer . ^^^ BACKGROUND : Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are Kunitz type serine protease inhibitors for hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Modified glutathione S transferase pull down assays demonstrated the interaction between the SP domain and hepatocyte growth factor activator inhibitor 1 . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , have been implicated in carcinoma onset and malignant progression . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| A novel biomarker for staging human prostate adenocarcinoma : overexpression of matriptase with concomitant loss of its inhibitor , hepatocyte growth factor activator inhibitor 1 . ^^^ Here , we establish the clinical significance of matriptase and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , during the progression of human prostate cancer ( CaP ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is required for branching morphogenesis in the chorioallantoic placenta . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a membrane associated Kunitz type serine proteinase inhibitor that was initially identified as a potent inhibitor of hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Serum hepatocyte growth factor activator ( HGFA ) in benign prostatic hyperplasia and prostate cancer . ^^^ OBJECTIVES : Hepatocyte growth factor activator ( HGFA ) is responsible for proteolytic activation of the precursor form of hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Diverse roles of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in the growth of glioblastoma cells in vivo . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is an integral membrane proteinase inhibitor . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Identification of hepatocyte growth factor activator inhibitor 1B as a potential physiological inhibitor of prostasin . ^^^ We found the expression profile of prostasin in normal human tissues to correlate highly with hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) and its splice variant HAI 1 . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Role of hepatocyte growth factor activator ( HGF activator ) in invasive growth of human glioblastoma cells in vivo . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Expression of serine protease SNC19 / matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract . ^^^ AIM : To provide the expression profile of serine protease SNC19 / matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in normal and malignant tissues of gastrointestinal tract at mRNA level for further study on their correlations with tumor progression and metastasis . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| We show here that a serine protease specific for HGF , HGF activator ( HGFA ) , is expressed and activated by the ureteric bud of the developing kidney in vivo and in vitro . ^^^ HGFA was localized around the tips of the ureteric bud in developing kidneys , while HGF was expressed diffusely throughout the mesenchyme . ^^^ The localization of HGFA to the ureteric bud and the mesenchyme immediately adjacent to it suggests that HGFA creates a gradient of HGF activity in the developing kidney . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| This processing activity was enhanced by thrombin treatment but was inhibited significantly by a neutralizing antibody against HGF activator ( HGFA ) , a factor XIIa like serine proteinase believed to be expressed mainly in the liver . ^^^ Therefore , extrahepatic expression of HGFA in the colorectal carcinoma cells could be responsible for the single chain HGF / SF processing activity of the cells . ^^^ It was concluded that HGFA is expressed in colorectal mucosa and tumors and could be involved in the activation of HGF / SF in colorectal carcinomas . ^^^ Therefore , the balance between HGFA and HAI 1 could play an important role in the regulation of HGF / SF activity in colorectal carcinomas . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Its actions are dependent on activation by HGF activator ( HGFA ) and its binding to a specific HGF receptor ( c Met ) . ^^^ We examined the role of HGF , HGFA , and c Met in synovial tissues in rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) , and their localization and mRNA expression . ^^^ METHODS : Immunohistochemical staining , Western blotting , RT PCR , and in situ hybridization ( ISH ) for HGF , HGFA , and c Met were performed on synovial tissue specimens from 10 patients with RA and 4 with OA , and 2 healthy controls . ^^^ RT PCR showed HGF , HGFA , and c Met mRNA in RA , OA , and control synovial tissue . ^^^ ISH and immunohistochemistry revealed mRNA expression for HGF , HGFA , and c Met in the cell types mentioned above . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Monoclonal antibody ( MAb ) MG 2 was specific to villous cytotrophoblast across gestation , and recognizes hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Matriptase is a type 2 transmembrane serine protease expressed in most human epithelia , where it is coexpressed with its cognate transmembrane inhibitor , hepatocyte growth factor activator inhibitor ( HAI ) 1 . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| As it exerts its effect only after a conversion to its heterodimeric active form , the activation step , which is catalyzed by an enzyme serine protease named HGF activator ( HGFA ) , is of great importance . ^^^ HGF activated by HGFA may act as a protecting agent in injured brain . ^^^ In the present study , we investigated expression of immunoreactive HGF and HGFA in rat brain after permanent middle cerebral artery ( MCA ) occlusion . ^^^ By immunohistochemical analysis , HGF and HGFA were normally expressed only in ependymal cells and choroid plexus . ^^^ At 3 h of ischemia , however , immunoreactive HGF as well as HGFA became detectable in neurons of the ischemic cerebral cortex and caudate . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Since HGF is secreted as an inactive form ( proHGF ) , and converted to an active form by serine proteases such as HGF activator ( HGFA ) , extracellular processing of proHGF is presumed to be critical in the regulation of HGF activity . ^^^ To examine the role of the HGF system in epithelial invasion followed by loss of connective tissue attachment in periodontitis , mRNA expression of HGF , its receptor ( c met ) and HGFA in gingival tissues was monitored . ^^^ The gene expression of HGF and keratinocyte growth factor ( KGF ) in gingival connective tissue , and c met , HGFA and KGF receptor ( KGFR ) in gingival epithelial tissues was monitored using RT PCR . ^^^ In terms of local production and activation of HGF in gingival tissue , these results suggest that synergistic expression of HGF in connective tissue and HGFA expression in epithelium may contribute to disease progression in periodontitis . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Morphological and functional restoration of the liver were examined , as well as activation of mitogen activated protein kinase ( MAPK ) and mRNA levels of HGF activator ( HGFA ) . ^^^ Therapy with HGF in cirrhotic PHx resulted in effective liver regeneration via restoration of HGFA and activation of MAPK p44 / p42 , accelerated normalisation of liver function , and increased collagen degradation . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The HGF activator ( HGFA ) is a coagulation factor 12 like serine proteinase critically involved in this process in injured tissues including tumor tissues . ^^^ This review is a summary and interpretation of recent data regarding the regulation of pericellular HGF / SF activation mediated by HGFA and HAIs and includes a discussion of the possible role of the type 1 transmembrane Kunitz type inhibitor in pericellular proteolysis . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| However , HGF / c Met autocrine activity requires the presence of a serine protease , the HGF activator ( HGFA ) , and , in some cells , the CD 44 transmembrane glycoprotein . ^^^ Here , we found that HGFA , HGF , c Met , and CD 44 are coexpressed in MPNSTs but their localization did not correlate with increased cell proliferation . ^^^ These data indicate that an HGF / c Met autocrine loop can promote MPNST invasion through a CD 44 independent mechanism and suggest that c Met , HGFA , and HGF are potential molecular targets to inhibit MPNST metastasis . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| This factor is produced as an inactive precursor called pro HGF , which requires proteolytic conversion , by HGF activator ( HGFA ) and matriptase , to evoke a biological response . ^^^ Two new HGFA inhibitors , HAI 1 and HAI 2 , inhibit the generation of biologically active HGF , through their interaction with HGFA . ^^^ We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND / AIMS : The activation pathway of hepatocyte growth factor ( HGF ) , including HGF activator ( HGFA ) and HGFA inhibitor 1 , 2 ( HAI 1 , 2 ) , has recently been clarified . ^^^ The present study examined mRNA expressions of HGF , HGFA and HAI 1 following partial hepatectomy in normal and cirrhotic rats . ^^^ Two weeks after , the cirrhotic and normal rats underwent 70 % hepatectomy and the liver regeneration rate , DNA synthesis of hepatocytes , plasma HGF level , and mRNA expressions of HGF , HGFA , and HAI 1 in the liver , spleen , and lung were examined at different times . ^^^ Hepatic HGF mRNA and splenic HAI 1 mRNA were upregulated and liver HGFA mRNA was downregulated in the cirrhotic rats . ^^^ CONCLUSIONS : Insufficient HGF activation both by a reduced expression of hepatic HGFA and an increased expression of splenic HAI 1 may be one of the reasons for the impaired liver regeneration in cirrhosis . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Here , we show that malignant MM plasma cells convert HGF into its active form and secrete HGF activator ( HGFA ) , a serine protease specific for HGF activation . ^^^ By using serine protease inhibitors and neutralizing antibodies , we demonstrate that HGFA produced by the MM cells is responsible for their ability to catalyze HGF activation . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| HGF is produced as a single chain precursor ( pro HGF ) and functions after activation by HGF activator ( HGFA ) . ^^^ In this study , we aimed to examine the activation of pro HGF to mature HGF and the expressions of HGF related molecules , such as HGFA and HGFA inhibitor type 1 ( HAI 1 ) , in a monkey model of gastric mucosal injury . ^^^ HGF activation was evaluated by Western blotting and enzyme linked immunosorbent assay ( ELISA ) , and the expression of HGF , HGFA , HAI 1 , and c Met were examined by Northern blotting and immunohistochemistry . ^^^ CONCLUSIONS : These results indicate that pro HGF is stored in normal gastric tissues , and suggest that its conversion to mature HGF , associated with HGFA and HAI 1 , is important for the repair of gastric mucosal injury . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The biologically active HGF ( baHGF ) , which was converted by an HGF activator protein from secretory type proHGF , showed significantly higher expression in pretreated PC than in non treated PC . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Moreover , GBM cells also co express HGF activator , a recently identified serine proteinase having efficient HGF / SF activating activity . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| In the present study we have examined the expression of regulatory components of the HGF / MET pathway , including HGF activator ( HGFA ) , within the secondary lymphoid organ microenvironment . ^^^ Both HGF and HGFA are expressed by FDCs in the GC dark zone ( CD21high / CD23low ) , but not in the light zone ( CD21high / CD23high ) . ^^^ These findings suggest that HGF and HGFA provided by dark zone FDCs help to regulate the proliferation , survival , and / or adhesion of MET positive centroblasts . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Within the tumor microenvironment of DLBCL , HGF is provided by macrophages , whereas DLBCL cells themselves produce the serine protease HGF activator ( HGFA ) , which autocatalyzes HGF activation . ^^^ Taken together , these data indicate that HGF / MET signaling , and secretion of HGFA by DLBCL cells , contributes to lymphomagenesis in DLBCL . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The women ' s plasma concentrations of total HGF , active HGF , active HGF activator ( HGFA ) , HGF activator inhibitor type 1 ( HAI 1 ) and HGF activator inhibitor type 2 ( HAI 2 ) were determined by enzyme linked immunosorbent assay . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| HGF activator ( HGFA ) , matriptase , urokinase type plasminogen activator and hepsin are the main factors responsible for converting pro HGF into active HGF . ^^^ HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Recently , a novel serine protease responsible for this processing ( HGF activator ) has been purified from fetal bovine serum ( Shimomura , T . , Ochiai , M . , Kondo , J . , and Morimoto , Y . ( 1992 ) Cytotechnology 8 , 219 229 ) . ^^^ In this study , we purified HGF activator from human serum and determined its partial amino acid sequence . ^^^ Based on the amino acid sequence , we have molecularly cloned the cDNA for human HGF activator . ^^^ The nucleotide sequence of the cDNA revealed that HGF activator is derived from the COOH terminal half region of a precursor protein of 655 amino acids and that the precursor consists of multiple putative domains homologous to those observed in blood coagulation factor 12 . ^^^ These domains may be involved in the conversion of the precursor to the active form of HGF activator . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The secreted inactive form of HGF is processed into an active form by serine proteinases such as HGF activator and urokinase . ^^^ The mRNA of HGF , HGF activator , urokinase , plasminogen activator inhibitor ( PAI ) 1 , nexin 1 , matrix metalloproteinase ( MMP ) 2 , and tissue inhibitor of metalloproteinase ( TIMP ) 1 were expressed strongly in anagen tissue and slightly in telogen tissue . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Phylogenetic analysis of protease domains of the vertebrate plasminogen prothrombin family revealed two major subfamilies : ( 1 ) a subfamily containing macrophage stimulating protein ( MSP ) , hepatocyte growth factor ( HGF ) , plasminogen , and apolipoprotein ( a ) ( APOA ) ; and ( 2 ) a subfamily containing prothrombin , HGF activator , and plasminogen activators . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Conversion of a single chain form of HGF ( pro HGF ) into an HGF heterodimer was unexpected , as pro HGF is normally cleaved by a serum protease called HGF activator . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are new Kunitz type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN 45 as specific inhibitors against HGF activator . ^^^ Upregulation of HGF activator inhibitor type 1 but not type 2 along with regeneration of intestinal mucosa . ^^^ Hepatocyte growth factor ( HGF ) activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are new Kunitz type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN 45 as specific inhibitors against HGF activator . ^^^ |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a paracrine factor secreted by follicular papilla cells , acts on neighboring follicular epithelial cells to promote follicular growth , while HGF activator is a serine proteinase , which converts inactive single chain HGF to the active heterodimeric form . ^^^ Hepatocyte growth factor ( HGF ) , a paracrine factor secreted by follicular papilla cells , acts on neighboring follicular epithelial cells to promote follicular growth , while HGF activator is a serine proteinase , which converts inactive single chain HGF to the active heterodimeric form . ^^^ In this study , using 3 ' rapid amplification of cDNA end / nested polymerase chain reaction ( 3 ' RACE / nested PCR ) and immunoblotting , we confirmed the expression of HGF activator in both cultured human follicular papilla cells and outer root sheath cells . ^^^ HGF activator mRNA was expressed in all of the isolated 15 anagen hair follicles taken from the scalps of seven individuals . ^^^ These results suggest that single chain HGF secreted from follicular papilla cells is converted to an active heterodimeric form by intrinsic HGF activator and that the resultant active form of HGF stimulates hair growth . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NYGM cells concomitantly expressed MET receptor tyrosine kinase ( a product of c met protooncogene ) and its ligand HGF / SF ( hepatocyte growth factor / scatter factor ) , as well as HGF activator and HGF activator inhibitors . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Various proteases reportedly cleave scHGF to generate the active two chain form ( HGF ) , including u PA ( urokinase type plasminogen activator ) , t PA ( tissue type plasminogen activator ) , kallikrein , Factor XIa , Factor XIIa , HGF activator and matriptase . ^^^ |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Studies were performed to examine whether the exogenous administration of recombinant human ( rh ) HGF activator converts proHGF to biologically active ( mature ) HGF , inducing an enhancement of liver regeneration in cirrhosis . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| In this study , we hypothesized that HGF , activated through the action of thrombin on the HGF activator , may enhance BMP action through the local induction of BMP or BMPRs . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Additionally , the proteolytic activation of HGF , which is mediated by HGF activator , is essential for the regeneration of injured intestinal mucosa . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF . ^^^ However , a significant amount of inactive HGF precursor ( proHGF ) is reported in the plasma of these patients . proHGF is proteolytically converted to an active form ( mature HGF ) by HGF activator . ^^^ Recombinant human HGF activator was administered via the portal vein to investigate the effect on molecular forms of HGF and its biological signaling . rhHGF activator promptly converted proHGF into mature HGF , reaching maximal levels at 5 10 min after the injection , while the decreased proHGF was quickly recovered to the initial levels in the liver . ^^^ These results indicate that exogenously administered HGF activator produces a biologically active HGF from its precursor form and increases the potential for liver regeneration in vivo . . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| The novel serine protease HGF activator and urokinase type plasminogen activator ( u PA ) are responsible for the latter extracellular processing . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , HGF activator inhibitor 1 ( HAI 1 ) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu , suggesting that the inhibitor serves to prevent undesired proteolysis in these cells . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| Effect of exogenously administered HGF activator in liver regeneration . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| In addition to finding macromolecular hepsin substrates , the extracellular inhibitors of the HGF activator , HAI 1 and HAI 2 , were potent inhibitors of hepsin activity ( IC 50 4+ / 0 . 2 nM and 12+ / 0 . 5 nM respectively ) . ^^^ |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and P14210 |
Pubmed |
SVM Score :0.0 |
| NA |
|