| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| In the present study , we purified a second type of HGF activator inhibitor ( HAI 2 ) from the conditioned medium of MKN 45 cells and molecularly cloned its cDNA . ^^^ Because HAI 2 and HAI 1 are potent inhibitors specific for HGF activator , they may be involved in regulation of proteolytic activation of HGF in injured tissues . . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was identified as a potent inhibitor of hepatocyte growth factor activator ( HGF activator ) . ^^^ Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was identified as a potent inhibitor of hepatocyte growth factor activator ( HGF activator ) . ^^^ These results suggest that the NH 2 terminal Kunitz domain is mainly responsible for the HGF activator inhibitory activity of HAI 2 . . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a new Kunitz type serine protease inhibitor , which is purified and cloned from human stomach cancer cell line MKN 45 . ^^^ The mature HAI 2 protein contains two Kunitz domains and the first domain is mainly responsible for the inhibitory activity against hepatocyte growth factor activator ( HGFA ) . ^^^ These results suggest that most of HAI 2 expressed in various tissues of mice may be unable to inhibit HGFA efficiently . . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was recently identified as a potent inhibitor of hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| To date , two specific inhibitors of HGFA have been identified , namely HGFA inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) / placental bikunin ( PB ) . ^^^ Here we show that an active form of HGFA is specifically complexed with membrane form HAI 1 , but not with HAI 2 / PB , on the surface of epithelial cells expressing both inhibitors . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Identification of hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) : its nuclear localization and generation of chimeric mRNA transcribed from both HAI 2 and H2RSP genes . ^^^ A novel small gene , designated hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) was cloned and characterized in the process of the search for splicing variant forms of HAI 2 by 3 ' rapid amplification of cDNA ends ( RACE ) . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a serine proteinase inhibitor containing two Kunitz type inhibitor domains , initially identified as a potent inhibitor of hepatocyte growth factor activator ( HGFA ) . ^^^ Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a serine proteinase inhibitor containing two Kunitz type inhibitor domains , initially identified as a potent inhibitor of hepatocyte growth factor activator ( HGFA ) . ^^^ Since KD 1 was reported to be responsible for the inhibition of HGFA in human HAI 2 and the second Kunitz domain ( KD 2 ) of human HAI 2 was much less inhibitory against HGFA , it has been suggested that most of mouse HAI 2 may be ineffective in inhibiting HGFA . ^^^ The results revealed that , unlike human HAI 2 , KD 2 of mouse HAI 2 efficiently inhibits HGFA . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are new Kunitz type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN 45 as specific inhibitors against HGF activator . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepsin activates pro hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) and HAI 2 . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| In addition to finding macromolecular hepsin substrates , the extracellular inhibitors of the HGF activator , HAI 1 and HAI 2 , were potent inhibitors of hepsin activity ( IC 50 4+ / 0 . 2 nM and 12+ / 0 . 5 nM respectively ) . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Serum hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) in prostate cancer . ^^^ BACKGROUND : Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are Kunitz type serine protease inhibitors for hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) in human testis : identification of a distinct transcription start site for the HAI 2 gene in testis . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently identified integral membrane Kunitz type proteinase inhibitors . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The activity of HGFA is regulated by two recently identified Kunitz type serine proteinase inhibitors , namely HGFA inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Characterization of transcripts generated from mouse hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) and HAI 2 related small peptide ( H2RSP ) genes : chimeric mRNA transcribed from both HAI 2 and H2RSP genes is detected in human but not in mouse . ^^^ We previously reported a novel small gene , designated hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) , in the process of the search for splicing variant forms of HAI 2 by 3 ( ' ) rapid amplification of cDNA ends method [ Biochem . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of HGFA and its endogenous inhibitors HAI 1 and HAI 2 in normal kidney and RCC . ^^^ MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Two new HGFA inhibitors , HAI 1 and HAI 2 , inhibit the generation of biologically active HGF , through their interaction with HGFA . ^^^ We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ CONCLUSIONS : This study shows that there are aberrant levels of HGF , c Met , HGFA , HAI 1 , and HAI 2 expressed in breast cancer tissues compared with background breast tissue . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The women ' s plasma concentrations of total HGF , active HGF , active HGF activator ( HGFA ) , HGF activator inhibitor type 1 ( HAI 1 ) and HGF activator inhibitor type 2 ( HAI 2 ) were determined by enzyme linked immunosorbent assay . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Ribosomal protein S 3 was underexpressed only in squamous cell carcinomas , whereas expression of hepatocyte growth factor activator inhibitor type 2 , ubiquitin conjugating enzyme UBC 9 , and clone 333E23 on chromosome Xq21 . 1 were altered only in adenocarcinomas . ^^^ |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43291 and Q04756 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Purification and cloning of hepatocyte growth factor activator inhibitor type 2 , a Kunitz type serine protease inhibitor . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was identified as a potent inhibitor of hepatocyte growth factor activator ( HGF activator ) . ^^^ Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2 . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a new Kunitz type serine protease inhibitor , which is purified and cloned from human stomach cancer cell line MKN 45 . ^^^ The mature HAI 2 protein contains two Kunitz domains and the first domain is mainly responsible for the inhibitory activity against hepatocyte growth factor activator ( HGFA ) . ^^^ Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz type serine proteinase inhibitor domain is a predominant product in mouse but not in human . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) was recently identified as a potent inhibitor of hepatocyte growth factor activator . ^^^ Conserved expression of hepatocyte growth factor activator inhibitor type 2 / placental bikunin in human colorectal carcinomas . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Ribosomal protein S 3 was underexpressed only in squamous cell carcinomas , whereas expression of hepatocyte growth factor activator inhibitor type 2 , ubiquitin conjugating enzyme UBC 9 , and clone 333E23 on chromosome Xq21 . 1 were altered only in adenocarcinomas . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) in human testis : identification of a distinct transcription start site for the HAI 2 gene in testis . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently identified integral membrane Kunitz type proteinase inhibitors . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Characterization of transcripts generated from mouse hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) and HAI 2 related small peptide ( H2RSP ) genes : chimeric mRNA transcribed from both HAI 2 and H2RSP genes is detected in human but not in mouse . ^^^ We previously reported a novel small gene , designated hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) , in the process of the search for splicing variant forms of HAI 2 by 3 ( ' ) rapid amplification of cDNA ends method [ Biochem . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepsin activates pro hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) and HAI 2 . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Serum hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) in prostate cancer . ^^^ BACKGROUND : Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are Kunitz type serine protease inhibitors for hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Identification of hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) : its nuclear localization and generation of chimeric mRNA transcribed from both HAI 2 and H2RSP genes . ^^^ A novel small gene , designated hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) related small peptide ( H2RSP ) was cloned and characterized in the process of the search for splicing variant forms of HAI 2 by 3 ' rapid amplification of cDNA ends ( RACE ) . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 2 ( HAI 2 ) is a serine proteinase inhibitor containing two Kunitz type inhibitor domains , initially identified as a potent inhibitor of hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| To date , two specific inhibitors of HGFA have been identified , namely HGFA inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) / placental bikunin ( PB ) . ^^^ Here we show that an active form of HGFA is specifically complexed with membrane form HAI 1 , but not with HAI 2 / PB , on the surface of epithelial cells expressing both inhibitors . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| The activity of HGFA is regulated by two recently identified Kunitz type serine proteinase inhibitors , namely HGFA inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of HGFA and its endogenous inhibitors HAI 1 and HAI 2 in normal kidney and RCC . ^^^ MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Two new HGFA inhibitors , HAI 1 and HAI 2 , inhibit the generation of biologically active HGF , through their interaction with HGFA . ^^^ We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ CONCLUSIONS : This study shows that there are aberrant levels of HGF , c Met , HGFA , HAI 1 , and HAI 2 expressed in breast cancer tissues compared with background breast tissue . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| The women ' s plasma concentrations of total HGF , active HGF , active HGF activator ( HGFA ) , HGF activator inhibitor type 1 ( HAI 1 ) and HGF activator inhibitor type 2 ( HAI 2 ) were determined by enzyme linked immunosorbent assay . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are new Kunitz type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN 45 as specific inhibitors against HGF activator . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| In addition to finding macromolecular hepsin substrates , the extracellular inhibitors of the HGF activator , HAI 1 and HAI 2 , were potent inhibitors of hepsin activity ( IC 50 4+ / 0 . 2 nM and 12+ / 0 . 5 nM respectively ) . ^^^ |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and O43291 |
Pubmed |
SVM Score :0.0 |
| NA |
|