| Interacting proteins: Q03405 and P42224 |
Pubmed |
SVM Score :0.0 |
| Upon clustering of uPA . uPAR complex by a monoclonal antibody , JAK 1 associates with uPAR , which in turn leads to STAT 1 phosphorylation , dimerization , specific binding to DNA , and gene activation . ^^^ To prove the dependence of STAT 1 activation on the uPAR , TCL 598 cells were treated with sense and antisense uPAR oligonucleotides . ^^^ In antisense treated cells in which uPAR expression was reduced to less then one third , activation of STAT 1 by the clustering antibody was abolished while STAT 1 activation by interferon gamma was unaffected . ^^^ |
|
| Interacting proteins: Q03405 and P42224 |
Pubmed |
SVM Score :0.0 |
| However , the important question whether other transcription factors of the Stat family , in addition to Stat 1 , are involved in the uPAR related signaling has not been addressed . ^^^ |
|
| Interacting proteins: Q03405 and P42224 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that both kinases are associated with the uPA receptor ( uPAR ) and mediate uPA induced activation of signal transducers and activators of transcription ( Stat 1 , Stat 2 , and Stat 4 ) in human vascular smooth muscle cells ( VSMC ) . ^^^ |
|
| Interacting proteins: Q03405 and P42224 |
Pubmed |
SVM Score :0.0 |
| The VSMC uPA receptor ( uPAR ) receives the signal and activates the transcription factor Stat 1 that , in turn , mediates the antiproliferative effects . ^^^ |
|
| Interacting proteins: Q03405 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|