| Interacting proteins: Q03405 and P29597 |
Pubmed |
SVM Score :0.0 |
| By using co immunoprecipitation techniques and in vitro kinase assays , the uPAR associated proteins were identified as Janus ( Jak ) and Src non receptor protein tyrosine kinases ( PTK ) Jak 1 , Tyk 2 , and p 59 ( fyn ) , p53 / 56 ( lyn ) , p53 / 59 ( hck ) , and p 55 ( fgr ) . ^^^ Migration experiments with double immunofluorescence staining revealed polarization of uPAR , and colocalization with Jak 1 and Tyk 2 to the leading edge of the migrating cells . ^^^ |
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| Interacting proteins: Q03405 and P29597 |
Pubmed |
SVM Score :0.0 |
| In human vascular smooth muscle cell ( VSMC ) uPA stimulates migration via the uPA receptor ( uPAR ) signalling complex containing the Janus kinase Tyk 2 and phosphatidylinositol 3 kinase ( PI 3 K ) . ^^^ We report that active GTP bound forms of small GTPases RhoA and Rac 1 , but not Cdc 42 , are directly associated with Tyk 2 and PI 3 K in an uPA / uPAR dependent fashion . ^^^ |
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| Interacting proteins: Q03405 and P29597 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P29597 |
Pubmed |
SVM Score :0.0 |
| NA |
|