| Interacting proteins: Q03405 and P08631 |
Pubmed |
SVM Score :0.0 |
| By using co immunoprecipitation techniques and in vitro kinase assays , the uPAR associated proteins were identified as Janus ( Jak ) and Src non receptor protein tyrosine kinases ( PTK ) Jak 1 , Tyk 2 , and p 59 ( fyn ) , p53 / 56 ( lyn ) , p53 / 59 ( hck ) , and p 55 ( fgr ) . ^^^ |
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| Interacting proteins: Q03405 and P08631 |
Pubmed |
SVM Score :0.0 |
| We have found that anti uPAR Ig precipitate the src type protein tyrosine kinases fyn , hck and lck , which belong to a family of structurally and functionally related effectors participating in signalling from antigen and cytokine receptors . ^^^ Of the three uPAR associated kinases , only hck is activated by uPA , whereas no changes in the activities of either fyn or lck could be detected by an in vitro immune complex kinase assay . ^^^ |
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| Interacting proteins: Q03405 and P08631 |
Pubmed |
SVM Score :0.0 |
| In this article we show that ( 1 ) both uPAR and FPRL1 / LXA4R are necessary for the chemotactic activity of uPA whereas FPRL1 / LXA4R is sufficient to mediate D2D3 ( 88 274 ) induced cell migration . ( 2 ) Inhibition or desensitization of FPRL1 / LXA4R by antibodies or specific ligands specifically prevents chemotaxis induced by D2D3 ( 88 274 ) in THP 1 cells and human peripheral blood monocytes . ( 3 ) Desensitization of FPRL1 / LXA4R prevents the activation of tyrosine kinase Hck induced by D2D3 ( 88 274 ) . ( 4 ) D2D3 ( 88 274 ) directly binds to FPRL1 / LXA4R and is competed by two specific FPRL1 / LXA4R agonists , the synthetic MMK 1 peptide and a stable analog of LXA 4 . ^^^ |
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| Interacting proteins: Q03405 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
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