| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.82307319 |
| Recombinant uPAR binds vitronectin in the absence of urokinase , but vitronectin binding is promoted by concurrent receptor binding of either urokinase or fragments thereof containing its uPAR binding domain . 0.82307319^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.72610321 |
| In ligand blotting experiments we found that vitronectin binds uPAR but not uPAR ( 2+3 ) . 0.72610321^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.78187908 |
| Our findings highlight the ability of uPAR to interact simultaneously with vitronectin and uPA in breast cancer , supporting a dynamic coupling of the molecular mechanisms underlying plasminogen dependent matrix degradation and cell adhesion . . 0.78187908^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.97408794 |
| Direct interactions of u PAR with vitronectin and integrins further regulate cell invasion . 0.97408794^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.50813333 |
| Although the urokinase receptor ( uPAR ) binds to vitronectin ( VN ) and promotes the adhesion of cells to this matrix protein , the biochemical details of this interaction remain unclear . 0.50813333^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The results suggest that the expression of uPAR in metastatic melanoma cells is linked to the expression and function of the vitronectin receptor . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Only the fraction of specific scuPA binding to trophoblasts that was dependent on uPAR was susceptible to inhibition by oleic acid , while binding of scuPA to vitronectin , thombospondin , and the alpha 2 macroglobulin receptor / low density lipoprotein related receptor was not . [ 3H ] Oleic acid bound specifically to recombinant soluble uPAR in a 1 : 1 molar ratio in the presence or absence of plasma and totally blocked its specific binding to a cell line expressing glycosyl phosphatidylinositol linked single chain urokinase . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The urokinase type plasminogen activator receptor ( uPAR ) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to vitronectin via a ligand binding site on uPAR . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Stimulation of monoblastic U 937 cells with transforming growth factor beta 1 and 1 , 25 ( OH ) 2 vitamin D 3 ( TGF beta 1 / D3 ) upregulates urokinase receptor ( uPAR ) and confers urokinase dependent adhesiveness to the cells for serum or vitronectin coated surfaces . ^^^ Recent studies show that uPAR itself is a high affinity adhesion receptor for vitronectin and that urokinase ( uPA ) is an activator of this adhesive function . ^^^ In the course of exploring possible G protein involvement in this adhesion it was observed that TGF beta 1 / D3 primed U 937 cells became adhesive to vitronectin in an uPAR dependent manner when exposed to pertussis toxin ( PTX ) . ^^^ Together these data indicate that PTX B subunit may bind to Mac 1 integrin , which leads to a rapid rise in [ Ca2+ ] 1 and subsequent activation of uPAR for adherence to vitronectin , suggesting a functional link between Mac 1 and activation of uPAR important to cellular trafficking and host defence in response to Bordetella pertussis infection . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Induction of the urokinase type plasminogen activator receptor ( uPAR ) promotes cell adhesion through its interaction with vitronectin ( VN ) in the extracellular matrix , and facilitates cell migration and invasion by localizing uPA to the cell surface . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Both receptors promote degradation of fibrin ( ogen ) and also confer adhesive properties on cells because Mac 1 and uPAR bind fibrin and vitronectin , respectively . ^^^ Induction of Mac 1 and uPAR expression on monocytic cell lines by transforming growth factor beta 1 and 1 . 25 ( OH ) 2 vitamin D 3 conferred urokinase and uPAR dependent adhesion to vitronectin , which was further promoted by engagement of Mac 1 . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Specifically , induction of cell surface expression of uPA . uPAR by growth factors or phorbol ester was necessary for vitronectin dependent carcinoma cell migration , an event mediated by integrin alphavbeta 5 . ^^^ Cell migration on vitronectin was blocked with either a soluble form of uPAR , an antibody that disrupts uPA binding to uPAR , or a monoclonal antibody to alphavbeta 5 . ^^^ Growth factor mediated induction of uPA . uPAR on the carcinoma cell surface promotes a specific motility event mediated by integrin alphavbeta 5 , since cells transfected with the beta 3 integrin subunit expressed alphavbeta 3 and migrated on vitronectin independently of growth factors or uPA . uPAR expression . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Here , we study the influence of the protease urokinasetype plasminogen activator ( uPA ) and its receptor ( uPAR ) on melanoma cell adhesion to , and migration on , the extracellular matrix protein vitronectin ( VN ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The staining patterns of uPAR and beta 1 integrins were strikingly similar when attached to fibronectin , laminin , or vitronectin but not polylysine coated substrates . ^^^ Resonance energy transfer ( RET ) between uPAR and beta 1 integrins was observed , especially at focal adhesion plaques ; this indicates that these molecules are within about 7 nm of each other on these cell membranes . uPAR and beta 3 integrin coclustering and RET were also observed on tumor cells adherent to vitronectin but not to fibronectin , laminin , or polylysine coated surfaces . ^^^ We found that : ( a ) alpha 5 colocalizes with uPAR on cells attached to fibronectin coated surfaces ; ( b ) alpha 5 and alpha ( 5 ) colocalize with uPAR on cells adherent to vitronectin ; and ( c ) alpha 3 and alpha 6 associate with uPAR on cells attached to laminin . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The di substitution does not affect pro uPA ability to interact with vitronectin or to enhance binding of urea denatured vitronectin to uPAR . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The difference in migration velocity was duplicated in culture wells that were precoated with serum or vitronectin and partially duplicated in wells coated with fibronectin but not in wells coated with type 1 collagen or Matrigel . uPA was detected in MEF 2 conditioned medium ( CM ) at a concentration of 0 . 30 + / 0 . 02 nM , which was 13 fold higher than the level detected in MEF 1 CM or PEA 10 CM , suggesting one potential mechanism for the enhanced migration of MEF 2 cells . uPAR was also increased on MEF 2 cells by 4 5 fold , as determined by PI PLC release , and by 2 . 5 fold , as determined by a uPA / uPAR activity assay . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The urokinase receptor ( uPAR ) coordinates plasmin mediated cell surface proteolysis and promotes cellular adhesion via a binding site for vitronectin on uPAR . ^^^ Because vitronectin also binds plasminogen activator inhibitor type 1 ( PAI 1 ) , and plasmin cleavage of vitronectin reduces PAI 1 binding , we explored the effects of plasmin and PAI 1 on the interaction between uPAR and vitronectin . ^^^ PAI 1 blocked cellular binding of and adhesion to vitronectin by over 80 % ( IC 50 approximately 5 nM ) , promoted detachment of uPAR bearing cells from vitronectin , and increased cellular migration on vitronectin . ^^^ Two peptides spanning res 364 380 blocked binding of uPAR to vitronectin ( IC 50 approximately 8 25 microM ) identifying this region as an important site of uPAR vitronectin interaction . ^^^ These data illuminate a complex regulatory scheme for uPAR dependent cellular adhesion to vitronectin : Active urokinase promotes adhesion and also subsequent detachment through activation of plasmin or complex formation with PAI 1 . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The urokinase receptor ( uPAR ) binds urokinase type plasminogen activator ( u PA ) through specific interactions with uPAR domain 1 , and vitronectin through interactions with a site within uPAR domains 2 and 3 . ^^^ These occur through a site within uPAR domains 2 and 3 , since the binding of 125I HKa to HUVEC is inhibited by vitronectin , anti uPAR domain 2 and 3 antibodies and soluble , recombinant uPAR ( suPAR ) , but not by antibody 7E3 , which recognizes the beta chain of the endothelial cell vitronectin receptor ( integrin alphavbeta 3 ) , or fibrinogen , another alphavbeta 3 ligand . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| In addition to its role in plasminogen activation , compelling evidence has demonstrated a role for uPAR in cell cell and cell extracellular matrix adhesion , both directly and indirectly . uPAR is directly involved in binding to the extracellular matrix molecule , vitronectin , and the affinity of this binding is increased when uPAR is occupied by ( pro ) uPA . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Regulation of the uPAR / uPA system expressed on monocytes by the deactivating cytokines , IL 4 , IL 10 and IL 13 : consequences on cell adhesion to vitronectin and fibrinogen . ^^^ The adhesive function of uPAR depends on a direct interaction with vitronectin which is increased by uPA and by modification of cell surface integrin ( such as CD11b CD 18 ) when associated to uPAR . ^^^ In this study we analysed the role of three deactivating cytokines , IL 4 , IL 10 and IL 13 , on the surface expression of uPA , uPAR and CD11b by monocytes and their consequences on monocyte adhesion to immobilized fibrinogen and vitronectin . ^^^ In addition , the increase in uPA induced by IL 4 could counterbalance the direct interaction of uPAR with vitronectin . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| These data suggest that uPA stimulates adhesion of SMCs specifically to vitronectin and that it is mediated by an interaction with uPAR . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The uPAR can bind to vitronectin , an adhesive extracellular matrix protein that contains the Arg gly Asp ( RGD ) cell adhesion domain and that serves as a ligand for several integrin receptors . uPAR also forms complexes with ( 1 , ( 2 , and ( 3 integrins , thereby allowing mutual interactions and regulation between cell adhesion and proteolysis . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Pro u PA induced a decrease in stress fiber content , membrane ruffling , actin ring formation , and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi ring located close to the leading edge of cells . u PAR effects on both chemotaxis and cytoskeleton were sensitive to pertussis toxin and , hence , possibly require G proteins . u PAR effects are accompanied by a relocation of u PAR , vitronectin receptor ( VNR ) alphavbeta 3 , beta 1 integrin subunit , and Src tyrosine kinase to the leading membrane of migrating cells . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Exposure to exogenous uPA increased uPA activity of cells exposed to wollastonite but not asbestos treated MeT5A cells . uPAR expression increased further when asbestos was preincubated with vitronectin ( VN ) or serum . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| To test the possibility that uPAR may physically and functionally interact with vitronectin ( Vn ) receptors , we determined the expression level of uPAR , alpha ( 5 ) beta 3 , and alpha ( 5 ) beta 5 Vn receptors in 10 human breast carcinomas . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Domain 1 of the urokinase receptor ( uPAR ) is required for uPAR mediated cell binding to vitronectin . ^^^ In the present paper we have analyzed uPAR mediated cellular binding to vitronectin using the murine erythroid progenitor cell line 32D . ^^^ We show that expression of uPAR in 32D cells promotes cellular binding to vitronectin , but fails to support cell spreading . ^^^ The failure of the mutant uPAR to promote cellular binding is paralleled by a strong reduction in the affinity for vitronectin in vitro . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| High motility also took place in medium containing a serum fraction passed by the 500 , 000 cutoff filter but retained by a 100 , 000 cutoff filter and in minimal medium containing added vitronectin ; however , under these conditions only a small percentage of the otherwise abundant focal adhesions contained colocalized uPAR . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Finally , VLA 4 engagement by VCAM 1 Fc or anti beta ( 1 ) integrin mAb induced uPAR dependent adhesion to immobilized vitronectin as well . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| On the other hand , mAb directed against uPAR significantly blocked PTX induced myeloid cell adhesion to serum and to immobilized vitronectin , a major extracellular matrix protein in serum . ^^^ Taken together , our data suggest that PTX may bind to cell surface CD 14 to induce myelomonocytic cell adhesion to vitronectin in serum via uPAR activation , which may represent a pathogenetic mechanism for the respiratory tract infection induced by Bordetella pertussis . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The results provide evidence that the vitronectin receptor can enhance invasion by regulating the uPAR / uPA / plasmin system of proteolysis and implicate PKCbeta as an intermediate in the activation pathway . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The role of vitronectin , PAI 1 , uPAR , and complement cascades in hantavirus pathogenesis are unstudied but may contribute to specific disease syndromes effected by hantaviruses . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The cytoskeletal changes are independent of uPA and activation of the RGD binding activity of integrins but require uPAR binding to vitronectin ( VN ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| We also show that SaOS 2 cells increase their proliferative response when cells are plated onto vitronectin , the second natural ligand of u PAR , and that culturing SaOS 2 cells in the presence of u PA represents a stimuli for u PAR expression . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Furthermore , uPAR ( 154 176 ) increased uPAR transfected BAF 3 cell adhesion on vitronectin in the presence of uPA , whereas uPAR ( 247 276 ) stimulated the cell adhesion both in the absence or presence of uPA . ^^^ The latter fragment was also able to augment the binding of vitronectin to uPAR in a purified system , thereby mimicking the effect of uPA on this interaction . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Translationally controlled display of UPAR by monocytes confers recognition of the matrix protein , vitronectin . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| On dissociation of the uPAR integrin complexes by p 25 , tumor cell attachment to the extracellular matrix was either decreased ( vitronectin ) or increased ( fibronectin ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Furthermore , adhesion to vitronectin and fibronectin was reduced by compounds that interfere with integrin function , such as EDTA , anti integrin antibodies , or by antibodies that interfere with the binding of pro uPA to uPAR , soluble uPAR , soluble vitronectin , phosphatidylinositol specific phospholipase C , as well as plasminogen activator inhibitor 1 . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Infecting the malignant glioma cell line SNB 19 with Ad uPAR , Ad p 16 , or Ad uPAR / p16 in the presence of vitronectin resulted in decreased alpha ( 5 ) beta ( 3 ) integrin expression and integrin mediated biological effects , including adhesion , migration , proliferation , and survival Our results support the therapeutic potential of simultaneously targeting uPAR and p 16 in the treatment of gliomas . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| It inhibits the adhesion of U 937 cells to vitronectin by competing with the urokinase receptor ( uPAR ; CD 87 ) on these cells for binding to the same domain . ^^^ These results affirm that PAI 1 can inhibit both uPAR and integrin mediated cell adhesion , and demonstrate that the SMB domain of vitronectin is required for these effects . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| In uPAR transfected 293 cells uPAR complexed ( > 90 % ) with alpha3beta1 and antibodies to alpha 3 blocked uPAR dependent vitronectin ( Vn ) adhesion . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Proteolytic cleavage of single chain , high molecular weight kininogen ( HK ) by kallikrein releases the short lived vasodilator bradykinin and leaves behind a two chain , high molecular weight kininogen ( HKa ) reported to bind to the beta 2 integrin Mac 1 ( CR 3 , CD11b / CD18 , alphaMbeta 2 ) on neutrophils and exert antiadhesive properties by binding to the urokinase receptor ( uPAR ) and vitronectin . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Urokinase ( uPA ) and urokinase receptor ( uPAR ) dependent cell adhesion to the extracellular matrix protein vitronectin ( Vn ) is an important event in wound healing , tissue remodeling , immune response , and cancer . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The presence of uPAR plays a crucial role in beta 2 integrin mediated adhesion of leukocytes ; uPAR also directly mediates leukocyte adhesion to vitronectin , a multifunctional adhesion protein that is associated with the extracellular matrix . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Adhesion of monocytes to the extracellular matrix is mediated by a direct high affinity interaction between cell surface urokinase type plasminogen activator ( uPA ) receptor ( uPAR ) and the extracellular matrix protein vitronectin . ^^^ We demonstrate a tight connection between uPA regulated uPAR oligomerization and high affinity binding to immobilized vitronectin . ^^^ We find that binding of soluble uPAR ( suPAR ) to immobilized vitronectin is strictly ligand dependent with a linear relationship between the observed binding and the concentration of ligand added . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Proteolytic cleavage of the urokinase plasminogen activator receptor ( uPA ( R ) ) prevents the binding of uPA and vitronectin while generating biologically active uPAR fragments . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The urokinase receptor ( urokinase plasminogen activator receptor ; uPAR ) regulates monocyte adhesion by direct binding to vitronectin and by forming complexes with integrins . ^^^ Isolated mononuclear cells ( MNCs ) from patients with AMI showed enhanced adhesiveness to human umbilical vein endothelial cells ( HUVECs ) , to fibrinogen ( Mac 1 ligand ) , and to vitronectin ( uPAR ligand ) . ^^^ The mAb anti uPAR R 3 blocked adhesion of cells from patients with AMI to vitronectin ( 95 % ) but also beta ( 2 ) integrin mediated adhesion to fibrinogen ( 79 % ) and HUVECs ( 66 % ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Urokinase type plasminogen activator ( uPA ) and vitronectin activate cell signaling pathways by binding to the uPA receptor ( uPAR ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The binding of urokinase plaminogen activator ( uPA ) to its cell surface receptor ( uPAR ; CD 87 ) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin ( VN ) and integrins . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Absence of the uPAR scavenger receptor was associated with significantly greater accumulation of plasminogen activator inhibitor 1 protein ( PAI 1 ) ( 20 . 5 + / 3 . 5 versus 9 . 1 + / 2 . 9 % area , day 14 UUO ) and vitronectin protein ( 2 . 4 + / 1 . 1 versus 0 . 9 + / 0 . 4 % area , day 14 UUO ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The receptor for urokinase type plasminogen activator ( uPAR ) plays important roles in a number of physiological and pathological processes by virtue of its interactions with urokinase type plasminogen activator ( uPA ) , vitronectin ( Vn ) , and several other proteins . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Secondly , uPA / uPAR regulates cell / ECM interactions as an adhesion receptor for vitronectin ( Vn ) and through its capacity to modulate integrin function . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Functionally , peptides uPAR ( 84 95 ) and uPAR ( 240 248 ) could partially inhibit differentiated human U 937 monocyte adhesion to vitronectin in the presence of uPA , indicating that these two uPAR regions might be involved not only in uPAR uPAR but also in uPAR vitronectin interactions . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| METHOD : We studied urokinase ( uPA ) , tissue type plasminogen activator ( tPA ) , urokinase receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) expression by in situ hybridization and by immunohistochemistry in 14 NF 2 and 15 sporadic patients with 34 schwannomas . uPAR and vitronectin immunohistochemistry were also studied . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| To understand alterations to the urokinase system that may occur in progressively metastatic prostate cancer cells , we assessed urokinase plasminogen activator receptor ( uPAR ) expression , in vitro motility towards vitronectin , urokinase plasminogen activator ( uPA ) induced growth and growth factor regulation of uPAR expression in three cell lines PC 3 and two derivatives from secondary metastases , PC 3M and PC 3MM2 . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The N terminal cysteine rich somatomedin B ( SMB ) domain ( residues 1 44 ) of the human glycoprotein vitronectin contains the high affinity binding sites for plasminogen activator inhibitor 1 ( PAI 1 ) and the urokinase receptor ( uPAR ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The human uPAR expressing Raw264 . 7 cells showed increased adhesion to both human uPA and vitronectin ( Vn ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of uPA , tPA , urokinase receptor ( uPAR ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and vitronectin was investigated by immunohistochemical staining , in addition to uPA , tPA and PAI 1 expression by in situ hybridization , in samples from eight chronic venous ulcers , five decubitus ulcers , five well granulating acute wounds and five normal skin samples . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Binding of uPAR to the beta propeller of alpha3beta1 empowers vitronectin adhesion by this integrin . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The urokinase receptor ( uPAR ) is a key molecule of this system and can bind extracellular and cell membrane molecules such as urokinase ( uPA ) , vitronectin ( VN ) , integrins and chemotaxis receptors . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| This model reveals that the receptor binding module of uPA engages the uPAR central cavity , thus leaving the external receptor surface accessible for other protein interactions ( vitronectin and integrins ) . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Vitronectin ( VN ) induces cell migration by binding to alphavbeta 3 , but expression of the uPAR boosts its efficacy . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| Cell exposure to SRSRY peptide promotes directional migration on vitronectin coated filters , regardless of uPAR expression , in a specific and dose dependent manner , with maximal effect at a concentration level as low as 10 nm . ^^^ Moreover , cell exposure to SRSRY promotes FPR dependent vitronectin release and increased uPAR . alphavbeta5 vitronectin receptor physical association , indicating that alphavbeta 5 activity is regulated by the SRSRY uPAR sequence via FPR . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| The identification of new extracellular ligands , such as vitronectin , and of cell surface interactors , such as integrins and fMet Leu Phe receptors , shed new light on its possible roles , totally independent of the enzymatic properties of its ligand . uPAR ligands and interactors and the functional consequences of the multiple binding capability of this intriguing receptor are reviewed here . . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| HKa physically disrupts the complex by interfering with the binding of vitronectin to uPAR . ^^^ |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03405 and P04004 |
Pubmed |
SVM Score :0.0 |
| NA |
|