| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :1.1530117 |
| Most interestingly , the association of MT 1 MMP with phosphorylated caveolin 1 induced the recruitment of Src and a concomitant inhibition of the kinase activity of the enzyme , suggesting that this complex may be involved in the negative regulation of Src activity . 1.1530117^^^ The association of MT 1 MMP with phosphorylated caveolin 1 occurs in caveolae membranes and involves the cytoplasmic domain of MT 1 MMP because it was markedly reduced by mutation of Cys 574 and Val 582 residues of the cytoplasmic tail of the enzyme . 1.110888^^^ Overall these results indicate that MT 1 MMP associates with tyrosine phosphorylated caveolin 1 and that this complex may play an important role in MT 1 MMP regulation and function . . 0.55169598^^^ |
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| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :0.0 |
| This correlated with an increase in membrane type 1 matrix metalloproteinase ( MT 1 MMP ) protein expression , a crucial enzyme that promotes endothelial cell migration and tube formation , and of caveolin 1 , a protein that regulates tube formation . ^^^ |
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| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The results of cDNA arrays showed that 13 cancer related genes were up regulated > or =2 fold ( CDC25B , cyclin D 1 , PCNA , MET , Jagged 2 , Integrin alpha 3 , Integrin alpha 6 , Integrin beta 4 , Caveolin 2 , Caveolin 1 , MMP 13 , MMP 14 , and BIGH 3 ) and 5 genes were down regulated > or =2 fold ( CK 4 , Bad , IGFBP 2 , CSPCP , and IL 1RA ) in both ESCC cell lines at the mRNA level . ^^^ |
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| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :0.0 |
| MT 1 MMP , TIMP 2 , and the alphavbeta 3 integrin exhibited a similar pattern of staining , with pericellular patches that colocalized with either MMP 2 or caveolin 1 . ^^^ |
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| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Thus , ECM degradation triggered by MT 1 MMP / TIMP 2 / pro MMP 2 complex could be a novel mechanism of CAV . . ^^^ |
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| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Thus , MT 1 MMP is present at caveolae with caveolin 1 and both proteins together with alpha 5 beta 3 integrin colocalize at endothelial motility associated extensions . ^^^ Remarkably , caveolae traffic is required for proper MT 1 MMP localization , activity , and function in migratory ECs as demonstrated by both treatment with caveolae disrupting agents or selective targeting caveolin 1 expression by interference RNA . ^^^ |
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| Interacting proteins: P50281 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
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