| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.53821308 |
| In this work , we report that VEGFR 2 is localized in endothelial caveolae , associated with caveolin 1 , and that this complex is rapidly dissociated upon stimulation with VEGF . 0.53821308^^^ |
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| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that stimulation of endothelial cells with vascular endothelial growth factor ( VEGF ) induces dissociation of caveolin 1 from the VEGFR 2 receptor , followed by Src family kinase dependent tyrosine phosphorylation of the protein ( Labrecque , L . , Royal , I . , Surprenant , D . ^^^ |
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| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| VEGF stimulation results in the release of VEGFR 2 from caveolae / lipid rafts and caveolin 1 without affecting localization of ARF 6 , Rac 1 , or caveolin 1 in these fractions . ^^^ The egress of VEGFR 2 from caveolae / lipid rafts is contemporaneous with the tyrosine phosphorylation of caveolin 1 ( Tyr 14 ) and VEGFR 2 and with their association with each other . ^^^ |
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| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that caveolin 1 can function as a negative regulator of VEGF R ( KDR ) signal transduction in vivo . ^^^ |
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| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| According to the known functions of their genes , the clusters were designated as proliferating cell ( CDC 42 , TOP2A , FGFR 3 , MYC , etc . ) , neoangiogenesis and blood cell ( LCK , VAV 1 , KDR , VEGF , MMP 9 , SYK , PTPRS , and FLT 4 ) , invasion 1 and invasion 2 ( ADAM 17 , TRPM 2 , DUSP 6 , VIM , CAV 1 , CAV 2 , JAK 1 , PTPNS 1 , FYN , and PDGFB ) , HER 2 , and PSA / PSM / HER3 . ^^^ |
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| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that KDR is present on the plasma membrane , on endosomes , and in the perinuclear region of EC and colocalizes with early endosomal antigen ( EEA 1 ) , caveolin 1 , and dynamin 2 , a signal transducing GTPase involved in receptor endocytosis . ^^^ |
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| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|