| CD 147 which is a regulator of matrix metalloproteinase ( MMP ) production on the surface of many malignant tumor cells , shows a highly specific association with caveolin 1 ( Cav 1 ) . ^^^ This study investigated the possible role of Cav 1 in CD 147 glycosylation in the HcaF , HcaP and Hepa 1 6 mouse hepatocarcinoma cell lines , which have high , low and no metastatic potential in the lymph nodes , respectively , and in the normal mouse liver cell line IAR 20 . ^^^ Using an RNA interference ( RNAi ) strategy , we showed that the down regulation of Cav 1 in Hca F / RNAi cells could suppress the conversion of LG CD 147 to HG CD 147 , down regulate MMP 11 expression and decrease Hca F / RNAi cell invasion . ^^^ Conversely , a stable high expression of Cav 1 in Hepa 1 6 / Cav 1 cell could cause a specific increase of HG CD 147 , up regulate MMP 11 protein expression and enhance Hepa 1 6 / Cav 1 cell invasion . ^^^ In conclusion , Cav 1 expression leads to an increased proportion of HG CD 147 relative to LG CD 147 , increased production of MMP 11 and a higher invasive capability . ^^^ |