| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 is important in the regulation of ERK and cyclin D 1 . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 blocked the formation of neurites and the phosphorylation of Erk upon bFGF treatment in N2a cells . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| We find that co expression with caveolin 1 dramatically inhibits signaling from EGF R , Raf , MEK 1 and ERK 2 to the nucleus . ^^^ Peptides derived from this region of caveolin 1 also inhibit the in vitro kinase activity of purified MEK 1 and ERK 2 . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that caveolin 1 regulates shear activation of ERK . ^^^ Because caveolin 1 is not exposed to the outside , cells were minimally permeabilized by Triton 10 100 ( 0 . 01 % ) to deliver a neutralizing , polyclonal caveolin 1 antibody ( pCav 1 ) inside the cells . pCav 1 then bound to caveolin 1 and inhibited shear activation of ERK but not c Jun NH ( 2 ) terminal kinase . ^^^ Other antibodies , including m 2234 , which binds to caveolin 1 residues 1 21 , had no effect on shear activation of ERK . ^^^ Caveolin 1 residues 61 101 contain the scaffolding and oligomerization domains , suggesting that binding of pCav 1 to these regions likely disrupts the clustering of caveolin 1 or its interaction with signaling molecules involved in the shear sensitive ERK pathway . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| However , in the case of p 53 induced senescence , caveolin 1 was not induced , and EGF stimulation phosphorylated Erk 1 / 2 as much as young control cells . ^^^ Finally , we overexpressed caveolin 1 in young human diploid fibroblasts in which the activation of Erk 1 / 2 upon EGF stimulation was significantly suppressed . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| Indeed , caveolin 1 interacted with and potentiated the transactivation of an ERalpha mutant that can not be phosphorylated by extracellular signal regulated kinase ( ERK ) 1 / 2 [ ERalpha ( Ser ( 118 ) > Ala ) ] . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| We reduced the level of caveolin 1 in senescent human diploid fibroblasts using its antisense oligonucleotides and small interfering RNA , and this resulted in the restoration of normal growth factor responses such as the increased phosphorylation of Erk , the nuclear translocation of p Erk , and the subsequent activation of p Elk upon epidermal growth factor stimulation . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| In this cell line , caveolin 1 expression was up regulated , whereas , ERK was down regulated . ^^^ ERK was weakly but consistently co immunoprecipitated with alpha synuclein but caveolin 1 did not co immunoprecipitate with alpha synuclein . ^^^ Moreover , treatment of alpha synuclein overexpressing cells with caveolin 1 antisense oligonucleotides resulted in stimulation of ERK activity , with amelioration of the neuritic alterations . ^^^ Transduction of alpha synuclein overexpressing cells , with an adenoviral vector directing the expression of ERK , resulted in suppression of caveolin 1 expression and re establishment of the normal patterns of neurite outgrowth . ^^^ These results suggest that alpha synuclein may also interfere with ERK signaling by dysregulating caveolin 1 expression . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| METHODS : In the present study , we transfected caveolin 1 cDNA to rat primary mesangial cells and MES 13 cells , and examined the effects on Raf extracellular signal regulated protein kinase ( ERK ) kinase ( MEK ) mitogen activated protein ( MAP ) kinase pathway and cell proliferation stimulated by basic fibroblast growth factor ( bFGF ) and platelet derived growth factor ( PDGF ) . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| We found that palmitoylation of ERalpha enacts ERalpha association with the plasma membrane , interaction with the membrane protein caveolin 1 , and nongenomic activities , including activation of signaling pathways and cell proliferation ( i . e . , ERK and AKT activation , cyclin D 1 promoter activity , DNA synthesis ) . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that down regulation of endogenous caveolin 1 expression activates ERK and that activation of the p42 / 44 MAP kinase pathway is necessary to promote muscle regeneration . ^^^ Taken together , these results propose caveolin 1 as a novel regulator of satellite cell functions and suggest that the following signaling pathway modulates satellite cell activation during muscle repair : injured fibers release HGF > HGF down regulates caveolin 1 protein expression > down regulation of caveolin 1 activates ERK > activation of ERK promotes muscle repair by stimulating the proliferation and migration of MPCs toward the wounded area . . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK / ERK and caveolin 1 signaling . ^^^ The roles of MEK , ERK , the epsilon and alpha isoforms of protein kinase C ( PKC ) , and caveolin 1 in regulating collagen expression were studied in normal lung fibroblasts . ^^^ In another , increased PKCalpha induces caveolin 1 expression , which in turn inhibits MEK / ERK activation and collagen expression . ^^^ Consistent with their overexpression of collagen , scleroderma lung fibroblasts contain more activated MEK / ERK and less caveolin 1 than normal lung fibroblasts . ^^^ However , the distinctive levels of PKCepsilon , PKCalpha , and caveolin 1 in lung and dermal fibroblasts from scleroderma patients and control subjects indicate that the links between these signaling proteins and MEK / ERK must function differently in the four cell types . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| A shift in localization of phospho caveolin 1 from focal adhesions to caveolae induces CEMM internalization upon cell detachment , which mediates inhibition of Erk , PI ( 3 ) K and Rac . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| The Sprouty related protein , Spred 1 , localizes in a lipid raft / caveola and inhibits ERK activation in collaboration with caveolin 1 . ^^^ Caveolin 1 ( Cav 1 ) has been suggested to function as a negative regulator of mitogen stimulated proliferation and the Ras p42 / 44 ERK ( MAP kinase ) pathway in a variety of cell types . ^^^ |
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| Interacting proteins: Q03135 and P28482 |
Pubmed |
SVM Score :0.0 |
| Stress induced phosphorylation of caveolin 1 and p 38 , and down regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines . ^^^ |
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