| Interacting proteins: P25098 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Based on the identification of a consensus caveolin binding motif within the pleckstrin homology domain of GRK 2 , we tested the direct binding of purified full length GRK 2 to various glutathione S transferase caveolin 1 fusion proteins , and we discovered a specific interaction of GRK 2 with the caveolin scaffolding domain . ^^^ |
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| Interacting proteins: P25098 and Q03135 |
Pubmed |
SVM Score :0.0 |
| We questioned the effect of age on caveolin 1 expression and interaction between caveolin 1 and GRK 2 in vascular smooth muscle ( VSM ) isolated from 2 , 6 , 12 , and 24 mo old male Fischer 344 rat aorta . ^^^ Immunohistocytochemistry and confocal microscopy confirmed that GRK 2 and caveolin 1 colocalize in VSM . ^^^ These results suggest that in nonoverexpressed , intact tissue , the decline in beta AR mediated vasorelaxation may be caused by both a reduction in caveolin 1 expression and a reduction in binding of GRK 2 by caveolin 1 . ^^^ |
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| Interacting proteins: P25098 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
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