| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.66037388 |
| The purified caveolin 1 binds c Src , suppressing its autophosphorylation . 0.66037388^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| The activated pp 60 ( c Src ) and Fyn co immunoprecipitated with caveolin 1 in BPMVEC membrane . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 , a scaffolding protein of caveolae , is known to be tyrosine phosphorylated by Src kinases . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor receptor exposed to oxidative stress undergoes Src and caveolin 1 dependent perinuclear trafficking . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| PrP ( C ) associates in rafts with a variety of signalling molecules , including caveolin 1 and Fyn and Src tyrosine kinases . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that dramatic reduction of caveolin 1 expression occurs in mammary tumors derived from c Neu expressing transgenic mice and other transgenic mice expressing downstream effectors of Neu mediated signal transduction , such as Src and Ras . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the Src family kinase inhibitor , PP 1 , does not affect autophosphorylation of the receptor , but it does inhibit the EGF induced mobility shift and phosphorylation of caveolin 1 . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative Src ( dn Src ) and overexpression of wild type caveolin 1 also prevented gp 60 activated endocytosis . ^^^ Caveolin 1 overexpression resulted in the sequestration of G ( alphai ) with the caveolin 1 , whereas dn Src inhibited G ( alphai ) binding to caveolin 1 . ^^^ Thus , vesicle formation induced by gp 60 and migration of vesicles to the basolateral membrane requires the interaction of gp 60 with caveolin 1 , followed by the activation of the downstream G ( 1 ) coupled Src kinase signaling pathway . . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Constitutive and growth factor regulated phosphorylation of caveolin 1 occurs at the same site ( Tyr 14 ) in vivo : identification of a c Src / Cav 1 / Grb7 signaling cassette . ^^^ Using this approach , we show that caveolin 1 ( Y 14 ) is a specific tyrosine kinase substrate that is constitutively phosphorylated in Src and Abl transformed cells and transiently phosphorylated in a regulated fashion during growth factor signaling . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Palmitoylation of caveolin 1 at a single site ( Cys 156 ) controls its coupling to the c Src tyrosine kinase : targeting of dually acylated molecules ( GPI linked , transmembrane , or cytoplasmic ) to caveolae effectively uncouples c Src and caveolin 1 ( TYR 14 ) . ^^^ Previous studies have shown that caveolin 1 is phosphorylated on tyrosine 14 by c Src and that lipid modification of c Src is required for this phosphorylation event to occur in vivo . ^^^ However , the cellular factors that govern the coupling of caveolin 1 to the c Src tyrosine kinase remain largely unknown . ^^^ Here , we show that palmitoylation of caveolin 1 at a single site ( Cys 156 ) is required for coupling caveolin 1 to the c Src tyrosine kinase . ^^^ Furthermore , upon evaluating a battery of nonreceptor and receptor tyrosine kinases , we demonstrate that the tyrosine phosphorylation of caveolin 1 by c Src is a highly selective event . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| A phosphotyrosine dependent protein interaction screen reveals a role for phosphorylation of caveolin 1 on tyrosine 14 : recruitment of C terminal Src kinase . ^^^ Caveolin 1 is a substrate for nonreceptor tyrosine kinases including Src , Fyn , and Abl . ^^^ We identified two proteins in this screen that interact with caveolin 1 in a phosphorylation dependent manner : tumor necrosis factor alpha receptor associated factor 2 ( TRAF 2 ) and C terminal Src kinase ( Csk ) . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using pulmonary microvascular endothelial cells , we have identified the specific interactions between a cell surface albumin docking protein gp 60 and caveolin 1 as well as components of the signaling machinery , heterotrimeric G protein ( G ( 1 ) ) and Src family tyrosine kinase . ^^^ The Src induced phosphorylation of caveolin 1 is crucial in regulating interactions of caveolin 1 with other components of the signaling machinery such as G ( 1 ) , and key signaling entry of caveolae into the cytoplasm and endocytosis of albumin and other solutes . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| These results provide the first evidence that caveolin 1 and dynamin form a complex , and that the EGF induced tyrosine phosphorylation of dynamin occurs via a Src inhibitor sensitive signaling pathway that is associated with the aberrant actions induced by internalization defective EGF receptors . . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Endostatin associates with integrin alpha5beta1 and caveolin 1 , and activates Src via a tyrosyl phosphatase dependent pathway in human endothelial cells . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 phosphorylation in human squamous and epidermoid carcinoma cells : dependence on ErbB 1 expression and Src activation . ^^^ In addition , the EGF induced phosphorylation of caveolin 1 in A 431 cells was blocked by the Src kinase antagonists PP 1 and PP 2 , but not by the MEK inhibitor PD 98059 , the phosphoinositide 3 kinase inhibitors LY 294002 and wortmannin , or cytoskeleton disrupting agents , such as cytochalasin D , colchicine , and nocadazole . ^^^ Altogether , these data indicate that multiple human carcinoma cells exhibit an EGF receptor dependent tyrosine phosphorylation of caveolin 1 and that this process is sensitive to Src family kinase inhibitors . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Dissociation of the VEGFR 2 / caveolin 1 complex by VEGF or cyclodextrin led to a PP 2 sensitive phosphorylation of caveolin 1 on tyrosine 14 , suggesting the participation of Src family kinases in this process . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Oxidative stress activates both Src kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk : caveolin 1 and paxillin . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of ct betaARK also prevented Src mediated tyrosine phosphorylation of caveolin 1 and dynamin 2 and the resultant phosphorylation dependent association of dynamin 2 and caveolin 1 . ^^^ Also , the direct activation of Gbetagamma using a specific cell permeant activating peptide ( myristoylated SIRKALNILGYPDYD ) simulated the effects of gp 60 in inducing Src activation , caveolin 1 , and dynamin 2 phosphorylation as well as caveolae mediated endocytosis of cholera toxin subunit B . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src mediated tyrosine phosphorylation of caveolin 1 induces its association with membrane type 1 matrix metalloproteinase . ^^^ We have recently shown that stimulation of endothelial cells with vascular endothelial growth factor ( VEGF ) induces dissociation of caveolin 1 from the VEGFR 2 receptor , followed by Src family kinase dependent tyrosine phosphorylation of the protein ( Labrecque , L . , Royal , I . , Surprenant , D . ^^^ This interaction requires the phosphorylation of caveolin 1 on tyrosine 14 by members of the Src family of protein kinases , such as Src and Fyn , because it is completely abolished by expression of a catalytically inactive Src mutant or by site directed mutagenesis of tyrosine 14 of caveolin 1 . ^^^ Most interestingly , the association of MT 1 MMP with phosphorylated caveolin 1 induced the recruitment of Src and a concomitant inhibition of the kinase activity of the enzyme , suggesting that this complex may be involved in the negative regulation of Src activity . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| In manipulating Src family kinase ( SFK ) activity with knockdown of Csk or type 1 protein phosphatase ( PP 1 ) treatment , we observed coordinate increase and decrease in shear induced caveolin 1 phosphorylation , respectively . ^^^ |
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| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PI 3 K and Akt were resistant to activation when Src kinases were inhibited pharmacologically or by overexpression of a kinase dead c Src mutant . alpha ( 5 ) beta 3 integrins were identified to colocalize with PI 3 K / caveolin 1 complexes , and blockade of alpha ( 5 ) beta 3 integrins prevented Akt activation . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| ROS derived DRMs were dramatically enriched in caveolin 1 , contained significant amounts of transducin alpha and c Src , and were relatively devoid of arrestin . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Depletion of caveolin 1 also significantly reduced the ouabain induced accumulation of Na / K ATPase alpha 1 subunit , EGFR , Src , and MAPKs in clathrin coat vesicles , as well as early and late endosomes . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of caveolin 1 by oxidative stress is reversible and dependent on the c src tyrosine kinase but not mitogen activated protein kinase pathways in placental artery endothelial cells . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ouabain induced endocytosis of the Na / K ATPase depends on the activation of Src kinase , clathrin coated pits formation , and caveolin 1 ( the major component of caveolae ) . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Analysis of the light fraction indicated that both PLC gamma 1 and IP 3 receptors ( isoforms 2 and 3 , IP3R2 and IP3R3 ) were coenriched with the Na / K ATPase , caveolin 1 and Src . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ang 2 induced EGF R transactivation is mediated through cSrc , a proximal target of reactive oxygen species ( ROS ) derived from NAD ( P ) H oxidase ( NOX ) and is dependent on AT ( 1 ) R trafficking through caveolin 1 ( Cav 1 ) enriched lipid rafts . ^^^ |
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| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Simultaneous expression of caveolin 1 and E cadherin in ovarian carcinoma cells stabilizes adherens junctions through inhibition of src related kinases . ^^^ Together , our data suggest that caveolin 1 expression indirectly promotes cell cell adhesion in ovarian carcinoma cells by a mechanism involving inhibition of src related kinases . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Upon E 2 treatment , Src kinase is tyrosine phosphorylated , which , in turn , stimulates Src kinase to phosphorylate caveolin 1 . ^^^ |
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| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| The findings point to an antioncogenic role for CD 99 in osteosarcoma , likely through the regulation of caveolin 1 and inhibition of c Src kinase activity . . ^^^ |
|
| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we report that non receptor Src tyrosine kinase and the membrane protein caveolin 1 ( Cav 1 ) play a key role in the activation of RAGE by S100B in VSMCs . ^^^ S100B increased the activation of Src kinase and tyrosine phosphorylation of caveolin 1 in VSMCs . ^^^ |
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| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Uptake of fluorescent labeled albumin , as well as phosphorylation of Src kinase and caveolin 1 , was also determined . ^^^ Isoflurane also caused a twofold increase in Src and caveolin 1 phosphorylation . ^^^ |
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| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Accumulating evidence shows that endocytosis mediated by caveolae requires unique structural and signaling machinery ( caveolin 1 , src kinase ) , which indicates that caveolar endocytosis occurs through a mechanism which is distinct from other forms of lipid microdomain associated , clathrin independent endocytosis . ^^^ |
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| Interacting proteins: Q03135 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src activation induced the phosphorylation of caveolin 1 , Akt and eNOS , and promoted dissociation of eNOS from caveolin 1 . ^^^ |
|