| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.70719118 |
| Moreover , P gp interacts with caveolin 1 and caveolin 2 ; together , they form a high molecular mass complex . 0.70719118^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| By means of single and dual color FISH on metaphase , prometaphase , and interphase chromatin , 15 genes in rat Chr 4q11 q 23 ( Cdk 5 , Hgf , Dmtf 1 , Abcb 1 , Cyp 51 , Cdk 6 , Tac 1 , Asns , Cav 1 , Met , Wnt 2 , Cftr , Smoh , Braf , Arhgef 5 ) were mapped and aligned . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| MDR 1 mRNA expression was absent in the tumor of this fifth patient before chemotherapy , but both the mice receiving the corresponding xenograft and the patient showed expression of MDR 1 after C ' CAV treatment . ^^^ |
|
| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Opposite pattern of MDR 1 and caveolin 1 gene expression in human atherosclerotic lesions and proliferating human smooth muscle cells . ^^^ The objective of this study was to analyse cholesterol esterification and the expression of MDR 1 ( multidrug resistance ) , ACAT ( acyl CoA : cholesterol acyltransferase ) and caveolin 1 genes in atherosclerotic and healthy vascular walls , in SMCs obtained from atherosclerotic lesions and saphenous veins . ^^^ Results demonstrated higher levels of cholesterol esters , ACAT and MDR 1 mRNAs and lower levels of caveolin 1 mRNA in atherosclerotic segments compared to adjacent serial sections of the same artery and the corresponding non atherosclerotic arteries from cadaveric donors . ^^^ An increase in ACAT and MDR 1 expression and a concomitant decrease in caveolin 1 expression were also observed in SMCs isolated from atherosclerotic arteries as early as 12 h after serum stimulation . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 expression in ovarian carcinoma is MDR 1 independent . ^^^ We studied the role of caveolin 1 in tumor progression and prognosis in serous ovarian carcinoma and the association between caveolin 1 and MDR 1 expression . ^^^ The study involved immunohistochemical analysis for caveolin 1 and P glycoprotein ( P gp ) expression in 75 effusions and 90 solid lesions from ovarian and primary peritoneal carcinoma ; in situ hybridization for MDR 1 messenger RNA ( mRNA ) expression in 62 effusions and all 90 tumors ; and reverse transcription polymerase chain reaction ( RT PCR ) for caveolin 1 mRNA expression in 23 effusions . ^^^ Caveolin 1 protein expression showed no association with that of P gp protein or MDR 1 mRNA . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Results showed that serum induced VSMC proliferation was preceded by an increased ability of the cells to esterify cholesterol as well as by an increased expression of ACAT and multidrug resistance ( MDR 1 ) mRNAs and extracellular related kinases 1 / 2 ( ERK1 / 2 ) , whereas caveolin 1 levels were markedly decreased . ^^^ The effect was associated with a rapid inhibition of ERK1 / 2 mitogenic signaling pathway ; a down regulation of cyclin D 1 , ACAT , and MDR 1 mRNA ; and an up regulation of caveolin 1 . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Little is known about how caveolin 1 influences the expression of P glycoprotein ( P gp ) , an ABC transporter encoded by multi drug resistance ( MDR 1 ) gene . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Among them , the up regulated expression of ATP binding cassette transporter genes ( MDR 1 , MRP 1 , and MRP 2 ) , CD 55 , and PGK 1 and down regulated expression of Caveolin 1 were further confirmed by semiquantitative reverse transcriptase polymerase chain reaction ( PCR ) or real time PCR . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Caveolin 2 expression is also up regulated in MCF 7 AdrR cells , but neither caveolin 1 nor caveolin 2 were detected in MCF 7 cells stably transfected with P gp . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| The expression of P gp , EGF R , and caveolin 1 by these tumoral ependymocytes could be useful in studies on new drugs . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to identify the site of cellular expression of P gp in human brain in situ and to morphologically determine whether an association may exist between P gp and caveolin 1 , a structural and functional protein of the caveolar frame . ^^^ The study was carried out on human cerebral cortex by immunoconfocal microscopy with antibodies to both P gp and caveolin 1 . ^^^ The results show that P gp marks the microvessels of the cortex and that the transporter is localized in the luminal endothelial compartment , where it co localizes with caveolin 1 . ^^^ The demonstration of this co localization of P gp with caveolin 1 contributes a morphological backing to biochemical studies on P gp / caveolin 1 relationships and leads us to suggest that interactions between these molecules may occur at the BBB endothelia . . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To study the expression of P glycoprotein ( P gp ) , lung resistance related protein ( LRP ) , and caveolin 1 ( cav 1 ) in the human bronchial epithelial cell line 16HBE14o . ^^^ METHODS : The presence of P gp , LRP , and cav 1 in 16HBE14o cell layers was evaluated using immunocytochemical staining and visualization with confocal laser scanning microscopy ( CLSM ) . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Using confocal fluorescence microscopy , we determined that caveolin 1 and GM ( 1 ) colocalized , while Pgp and caveolin 1 , or Pgp and GM ( 1 ) , did not . ^^^ Our results suggest that Pgp does not interact directly with caveolin 1 , and is localized in intermediate density domains , distinct from classical lipid rafts and caveolae , which can be isolated using Brij 96 . . ^^^ |
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| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08183 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
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