| We examined the hypothesis that hyperglycemia induced changes in Cav 1 expression and p75NTR signaling may contribute to altered neurotrophism in DPN by modulating SC responses to neuregulins . ^^^ Intriguingly , nerve growth factor antagonized the enhanced mitogenic response of SCs to neuregulin 1 beta1 and inhibited the glucose induced down regulation of Cav 1 transcription , mRNA , and protein expression through p75NTR dependent activation of JNK . ^^^ Our data suggest that Cav 1 down regulation may contribute to altered neurotrophism in DPN by enhancing the response of SCs to neuregulins and that p75NTR mediated JNK activation may provide a mechanism for the neurotrophic modulation of hyperglycemic stress . . ^^^ |