| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Conversely , caveolin 1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes such as 5 abl and H ras ( G12V ) ; caveolae are absent from these cell lines . ^^^ Induction of caveolin 1 expression in 5 Abl transformed and H Ras ( G12V ) transformed NIH 3T3 cells abrogated the anchorage independent growth of these cells in soft agar and resulted in the de novo formation of caveolae as seen by transmission electron microscopy . ^^^ |
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| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 mRNA and protein expression are down regulated in NIH 3T3 cells in response to transformation by activated oncogenes , such as H Ras ( G12V ) and 5 Abl . ^^^ Down regulation of caveolin 1 protein expression by Ras is independent of ( 1 ) the type of activating mutation ( G12V versus Q61L ) and ( 2 ) the form of activated Ras transfected ( H Ras versus K Ras versus N Ras ) . ^^^ The activity of a panel of caveolin 1 promoter constructs was evaluated using transient expression in H Ras ( G12V ) transformed NIH 3T3 cells . ^^^ Using electrophoretic mobility shift assays we provide evidence that the caveolin 1 promoter ( from 156 to 561 ) is differentially bound by transcription factors in normal and H Ras ( G12V ) transformed cells . ^^^ |
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| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Finally , we determined the binding of [ ( 3 ) H ] labeled free cholesterol and recombinant H Ras to Cav 1 fusion proteins in vitro . ^^^ |
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| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| Activating point mutations were found in codon 12 of the K ras gene ( wild type : GGT ) in MIA ( GTT ) , H2T ( GAT ) , CAPAN 2 ( TGT ) , and PANC 1 ( GAT ) but not in CAV . ^^^ |
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| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| This study investigated the relation between cyclin D 1 expression and clinicopathological parameters in carcinoma of the ampulla of Vater ( CAV ) , and also assessed the relation between increased cyclin D 1 expression and beta catenin / k ras status in this series . ^^^ |
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| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| The deletion of active K ras in HKh 2 cells reduced the steady state levels of p 11 and caveolin 1 and the distribution of p 11 to caveolae . ^^^ |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and Q03135 |
Pubmed |
SVM Score :0.0 |
| NA |
|