| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.92517591 |
| Our findings indicate that although the EGFR associates with caveolin 1 constitutively , caveolin 1 is hyperphosphorylated only under oxidative stress , which is essential in transporting the EGFR to a perinuclear location , where it is not degraded and remains active . 0.92517591^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| We find that co expression with caveolin 1 dramatically inhibits signaling from EGF R , Raf , MEK 1 and ERK 2 to the nucleus . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Enhanced caveolin 1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of P gp , EGF R , and caveolin 1 by these tumoral ependymocytes could be useful in studies on new drugs . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| We found in cultured human keratinocytes that UV irradiation induced both caveolin 1 and EGFR phosphorylation . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| The endocytosis linked protein dynamin associates with caveolin 1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal growth factor receptor mutant . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| In those senescent cells , we found an increased level of caveolin proteins and strong interactions between caveolin 1 and EGFR . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Although caveolin 1 is thought to facilitate the interaction of receptors and signaling components , its role in epidermal growth factor receptor ( EGFR ) signaling remains poorly understood . ^^^ Ganglioside GM 3 inhibits EGFR autophosphorylation and may thus affect the interaction of caveolin 1 and the EGFR . ^^^ We report here that endogenous overexpression of GM 3 leads to the clustering of GM 3 on the cell membrane of the keratinocyte derived SCC 12 cell line and promotes co immunoprecipitation of caveolin 1 and GM 3 with the EGFR . ^^^ Overexpression of GM 3 does not affect EGFR distribution but shifts caveolin 1 to the detergent soluble , EGFR containing region ; consistently , caveolin 1 is retained in the detergent insoluble membrane when ganglioside is depleted . ^^^ GM 3 overexpression inhibits EGFR tyrosine phosphorylation and receptor dimerization and concurrently increases both the content and tyrosine phosphorylation of EGFR associated caveolin 1 , providing evidence that tyrosine phosphorylation of caveolin 1 inhibits EGFR signaling . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 phosphorylation in human squamous and epidermoid carcinoma cells : dependence on ErbB 1 expression and Src activation . ^^^ Previous studies have shown that EGF can induce the tyrosine phosphorylation of caveolin 1 in murine fibroblasts following ErbB 1 ( EGF receptor ) mutation or overexpression , but the cell signaling events linking EGF action with caveolin phosphorylation are not fully established . ^^^ We observed that EGF and HB EGF , but not heregulin , promoted caveolin 1 phosphorylation in A 431 cells , suggesting that these responses are linked to EGF receptor activation and not solely occurring via the activation of other endogenous ErbB family members . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Hence , ET 1 activates mesangial cell ERK1 / 2 predominantly through a pathway involving EGF R transactivation , leading to a mechanism involving attachment to caveolin 1 , presumably in caveolae . . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Oxytocin receptor elicits different EGFR / MAPK activation patterns depending on its localization in caveolin 1 enriched domains . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Antisense RNA mediated reduction of caveolin 1 expression in EGFR overexpressing tumor cells recapitulated these EGF induced effects and enhanced invasion into collagen gels . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Interactions of EGFR and caveolin 1 in human glioblastoma cells : evidence that tyrosine phosphorylation regulates EGFR association with caveolae . ^^^ A colocalization of EGFR , but not of EGFRvIII , with lipid rafts and caveolin 1 was observed by immunocytochemistry . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Depletion of caveolin 1 also significantly reduced the ouabain induced accumulation of Na / K ATPase alpha 1 subunit , EGFR , Src , and MAPKs in clathrin coat vesicles , as well as early and late endosomes . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Agonist induced phosphorylation and association of caveolin 1 with the AT ( 1 ) R was observed , consistent with a scaffolding role of caveolin during transactivation of the EGF R by Ang 2 . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| In addition , in a subgroup of 28 patients for whom the remaining tumor tissue was available , we examined the relationship among EGFR mutations , CA repeats in intron 1 of EGFR , EGFR and caveolin 1 mRNA levels , and increased EGFR gene copy numbers . ^^^ EGFR mutations tended to be associated with increased numbers of CA repeats and increased EGFR gene copy numbers but not with EGFR and caveolin 1 mRNA overexpression ( P = not significant ) . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Ang 2 induced EGF R transactivation is mediated through cSrc , a proximal target of reactive oxygen species ( ROS ) derived from NAD ( P ) H oxidase ( NOX ) and is dependent on AT ( 1 ) R trafficking through caveolin 1 ( Cav 1 ) enriched lipid rafts . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Additional changes in the DU 145 gene expression profile with potential interaction to ErbB signaling include down regulation of caveolin 1 and hypoxia inducible factor 1 alpha ( HIF 1 alpha ) , and up regulation of gelsolin , p 19 ( INK4D ) and Nur 77 . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| With these fresh tissues , semi quantitative RT PCR was performed by coamplification of the gene for caveolin 1 , EGFR and Akt 1 with beta actin . ^^^ But , the expression of caveolin 1 and EGFR was not significantly related . ^^^ In conclusion , caveolin 1 is more expressed in cancer tissues than normal colon and related with Akt 1 , not with EGFR expression in colorectal cancer tissues , which suggests that signaling for caveolin 1 affects Akt 1 activation , but this reaction is not initiated by EGFR stimulation in colon cancer . . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 is down regulated and inversely correlated with HER 2 and EGFR expression status in invasive ductal carcinoma of the breast . ^^^ Using a tissue microarray , caveolin 1 expression was also correlated with the expression of other antigens such as eostrogen receptor , progesterone receptor , epidermal growth factor receptor ( EGFR ) , HER 2 , beta catenin , E cadherin , p 53 , Ki 67 and with clinicopathological parameters . ^^^ Furthermore , a statistically significant inverse correlation between caveolin 1 and EGFR and HER 2 was noted ( P < 0 . 001 ) . ^^^ Caveolin 1 also shows an inverse correlation with EGFR and HER 2 , which fits with its function as a negative regulator of signal transduction . . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Stress induced phosphorylation of caveolin 1 and p 38 , and down regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| The results suggested that , along with PSA , PSM ( FOLH 1 ) , kallikrein 2 , and a 2 macroglobulin , cell signaling genes EGFR , HER 2 , HER 3 , TOP 2 , KRT 8 , KRT 18 , VEGF , CD 44 , VIM , CAV 1 , and CAV 2 may serve as diagnostic and prognostic markers in PC . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| Cyclin D 1 , Fosl 1 , Hsp 47 , EGFR and AR , and Cav 1 are selected as the possible candidate genes of the metastatic phenotype , which need to be validated in later experiments . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Knockdown of Cav 1 protein by small interfering RNA ( siRNA ) inhibits Ang 2 stimulated Rac 1 activation and membrane translocation , H2O2 production , ROS dependent epidermal growth factor receptor ( EGF R ) transactivation , and subsequent phosphorylation of Akt without affecting ROS independent extracellular signal regulated kinase 1 / 2 phosphorylation . ^^^ |
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| Interacting proteins: Q03135 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of 10 proteins ( CAV 1 , CD 44 , EGFR , MET , ETS 1 , GATA 3 , luminal cytokeratin CK 19 , basal cytokeratin CK5 / 6 , CD 10 , and ERM protein moesin ) encoded by luminal vs basal discriminator genes confirmed the subtype classification and the validity of the identified markers . ^^^ |
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