| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| Conversely , caveolin 1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes such as 5 abl and H ras ( G12V ) ; caveolae are absent from these cell lines . ^^^ Induction of caveolin 1 expression in 5 Abl transformed and H Ras ( G12V ) transformed NIH 3T3 cells abrogated the anchorage independent growth of these cells in soft agar and resulted in the de novo formation of caveolae as seen by transmission electron microscopy . ^^^ |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 mRNA and protein expression are down regulated in NIH 3T3 cells in response to transformation by activated oncogenes , such as H Ras ( G12V ) and 5 Abl . ^^^ In contrast , treatment of 5 Src and 5 Abl transformed NIH 3T3 cells with PD 98059 does not restore caveolin 1 expression . ^^^ |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 is a substrate for nonreceptor tyrosine kinases including Src , Fyn , and Abl . ^^^ A cDNA library was screened using the N terminus of caveolin 1 as bait in a yeast strain expressing the catalytic domain of Abl . ^^^ |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| Abl is required for oxidative stress induced phosphorylation of caveolin 1 on tyrosine 14 . ^^^ Tyrosine 14 is a consensus Abl phosphorylation site suggesting that caveolin 1 may be an Abl substrate . ^^^ We report here that expression of c Abl is required for oxidative stress induced caveolin 1 phosphorylation . ^^^ Oxidative stress induced tyrosine phosphorylation of caveolin 1 occurs only at the Abl site , tyrosine 14 . ^^^ Caveolin 1 is also a major phosphotyrosine signal detected in cells over expressing c Abl . ^^^ |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| Oxidative stress induced phosphorylation of caveolin 1 also requires expression of Abl [ Sanguinetti and Mastick ( 2003 ) Cell Signal . 15 , 289 298 ] . ^^^ |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| In comparison with the normal liver tissues from the healthy donors , it was found that while remained unmethylated the ABL , CAV , EPO , GATA 3 , LKB 1 , NEP , NFL , NIS and p27KIP1 genes , varying extents of the HCC specific hypermethylation were found associated with the ABO , AR , CSPG 2 , cyclin a 1 , DBCCR 1 , GALR 2 , IRF 7 , MGMT , MT1A , MYOD 1 , OCT 6 , p57KIP2 , p 73 , WT 1 genes , and demethylation with the MAGEA 1 gene , respectively . ^^^ |
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| Interacting proteins: Q03135 and P00519 |
Pubmed |
SVM Score :0.0 |
| The nonreceptor tyrosine kinase , proto oncogene cAbl is a substrate of Src and is a major mediator for ROS dependent tyrosine phosphorylation of Cav 1 . ^^^ We thus hypothesized that cAbl is important for ROS , cSrc , and Cav 1 dependent growth related AT1R signal transduction . ^^^ Cell fractionation shows that both EGF Rs and cAbl are found basally in Cav 1 enriched membrane fractions . ^^^ Knockdown of cAbl protein using small interference RNA inhibits Ang 2 stimulated : ( 1 ) trafficking of AT1R into , and EGF R out of , Cav 1 enriched lipid rafts ; ( 2 ) EGF R transactivation ; ( 3 ) appearance of the transactivated EGF R and phospho Cav 1 at focal adhesions ; and ( 4 ) vascular hypertrophy . ^^^ |
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