| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| In four experiments , bovine pulmonary artery ( BPA ) was incubated with GTN ( 0 . 1 mM ) in Krebs ' solution ( 2 mL ) containing 30 mM KCl , and in anaerobic conditions using 95 % Ar 5 % CO 2 , in a sealed micro Fernbach flask ( 6 . 2 mL volume ) . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| We have analyzed the expression of androgen receptor ( AR ) , progesterone receptor ( PR ) , estrogen receptor ( ER ) , clusterin ( CLU ) , complement C 3 ( C 3 ) , and GAPDH mRNA in the rat uterus following oral administration of ethinylestradiol ( EE ) , bisphenol A ( BPA ) , o , p ' DDT ( DDT ) , p tert octylphenol ( OCT ) and daidzein ( DAI ) . ^^^ Although DAI and BPA were very weak stimulators of uterine growth , these substances were able to alter the expression of AR , ER and C 3 very strongly . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| On the other hand , the xenoestrogens bisphenol A ( BPA ) and octyiphenol polyethoxilate ( OP ) do not exert any direct effect on calcium fluxes and AR in human spermatozoa either in basal conditions or in response to P challenge . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| Prenatal exposure to BPA increases the fibroblastic : smooth muscle cells ratio and decreases the number of AR positive cells of periductal stroma of the ventral prostate . ^^^ In contrast , no differences in AR expression were observed in epithelial cells between control and BPA treated groups . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| In the presented study , we have analysed effects of the environmental estrogens bisphenol A ( BPA ) , p tert octylphenol ( OCT ) , o , p ' DDT ( DDT ) and coumestrol ( COU ) on cell proliferation , apoptosis induction , progesterone receptor ( PR ) and androgen receptor ( AR ) mRNA expression and ER alpha protein expression in comparison to estradiol ( E 2 ) and the selective ER modulator ( SERM ) raloxifene ( RAL ) and the pure antiestrogen faslodex ( ICI 182780 ) in the human breast cancer cell line MCF 7 . ^^^ AR mRNA expression was down regulated by COU , but not effected by BPA , DDT and OCT . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| We show that BPA stimulated nuclear translocation of the tumor derived receptor ( AR T877A ) , albeit with delayed kinetics compared with dihydrotestosterone . ^^^ Moreover , the ability of BPA to stimulate AR T877A activity was demonstrated by reporter assays and by analysis of an endogenous AR target gene , prostate specific antigen . ^^^ Thus , BPA is able to activate AR T877A in the absence of androgens . ^^^ Lastly , full mitogenic function of BPA is dependent on activation of the tumor derived AR T877A . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| Adriamycin ( ADR ) was loaded into the BPA nanoparticles as a model drug . ^^^ The loading efficiencies and ADR content in the BPA nanoparticles decreased with increasing vitamin H content due to a lower hydrophobicity . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| In the ARhLBD activating signal cointegrator 1 ( ASC 1 ) yeast two hybrid system , which reflects the androgen dependent interaction between androgen receptor ( AR ) and its coactivator , ASC 1 , BPA and NP acted as potent AR antagonists comparable to a known strong antagonist , cyproterone acetate . ^^^ Ligand competition assays revealed that [ 3H ] 5alpha dihydroxytestosterone ( DHT ) binding to AR is inhibited a maximum of 30 and 40 % at approximately 5 nM of NP and 50 nM of BPA , respectively . ^^^ In addition , the nuclear translocation of green fluorescent protein ( GFP ) AR fusion protein in the presence of testosterone was affected by the addition of BPA and NP , which cause rather dispersed distribution of GFP AR between the nuclear and the cytoplasmic compartments . ^^^ Furthermore , in transient transfection assays , BPA and NP inhibited androgen induced AR transcriptional activity . ^^^ Taken together , the results suggest that BPA and NP affect multiple steps of the activation and function of AR , thereby inhibiting the binding of native androgens to AR , AR nuclear localization , AR interaction with its coregulator , and its subsequent transactivation . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| We have shown previously that a known xenoestrogen , bisphenol A ( BPA ) , activates a tumor derived AR mutant ( T877A ) , leading to androgen independent prostate cancer cell proliferation . ^^^ Here , we show that BPA cooperates with androgen to activate AR T877A as shown by both reporter assays and increased levels of prostate specific antigen expression . ^^^ Further investigations using both yeast and mammalian model systems revealed that multiple AR alleles are responsive to BPA , thus expanding the potential influence of xenoestrogens on prostate cancer . ^^^ Moreover , in vitro radioligand binding assay revealed that BPA alters 5alpha dihydrotestosterone binding to AR T877A likely through noncompetitive inhibition . ^^^ We also show that higher concentrations of BPA block proliferation of AR positive , androgen dependent prostate adenocarcinoma cells ( LNCaP and LAPC 4 ) , with a more modest inhibitory effect on androgen independent cells ( 22Rv 1 ) . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| We investigated BPA , 4 octylphenol ( OP ) and 4 nonylphenol ( NP ) for their agonistic and antagonistic activities by the AR reporter gene assay . ^^^ In conclusion , BPA , OP and NP all act as AR antagonists , and BPA possesses the highest activity . . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| Androgen like effects of BPA on prostates and seminal vesicles were assessed by the Hershberger assay , densitometric analysis of androgen receptor ( AR ) immunoreactivity , cell proliferation index and a morphometric analysis . ^^^ Staining intensity for AR immunoreactivity was increased at low but not at higher doses of BPA in comparison to the orchiectomized rats . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| Previously , we developed an androgen receptor ( AR ) mediated reporter gene assay system , and verified the antiandrogenic activity of bisphenol A ( BPA ) based on this assay . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Prophylactic use of DSG in living related renal transplant recipients treated with DST improves long term graft survival , even in patients with AR episodes . . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to estimate the influence of DST on LRTx graft function , acute rejection rate ( AR ) and survival in the early and late posttransplant period . ^^^ |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03001 and P15121 |
Pubmed |
SVM Score :0.0 |
| NA |
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