| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that yeast strains expressing human DNA topoisomerase 2 alpha provide a convenient system for studying drugs targeting the enzyme ; unlike mammalian systems , potential complications due to the presence of human DNA topoisomerase 2 beta can be eliminated in this system . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| Differential immunohistochemical staining for DNA topoisomerase 2 alpha and beta in human tissues and for DNA topoisomerase 2 beta in non Hodgkin ' s lymphomas . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression of the drug resistance related genes , multidrug resistance gene 1 ( MDR 1 ) , multidrug resistance associated protein gene ( MRP ) , and the DNA topoisomerase IIalpha , DNA topoisomerase IIbeta , and glutathione S transferase pi gene ( GST pi ) in three human hepatoma cell lines ( HepG 2 , HuH 7 , SK Hep 1 ) with or without drug treatment with interferon alpha ( IFN alpha ) and cisplatin ( CDDP ) , by a reverse transcription polymerase chain reaction ( RT PCR ) method and a competitive PCR method . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| A cloned yeast TOP 2 gene was modified to produce yeast DNA topoisomerase 2 ( EC 5 . 99 . 1 . 3 ) epitopically labeled at its amino or carboxyl terminus . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| A series of 13 anthrapyrazole compounds that are analogues of piroxantrone and losoxantrone were synthesized , and their cell growth inhibitory effects , DNA binding , topoisomerase IIalpha mediated ( EC 5 . 99 . 1 . 3 ) cleavage of DNA , and inhibition of DNA topoisomerase IIalpha decatenation catalytic activities were determined . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| The genes top2A and top2B encoding the two subunits of a DNA gyrase like enzyme have been cloned and sequenced . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| Structural organization of the human TOP2A and TOP2B genes . ^^^ Human topoisomerase IIalpha ( TOP2A ) is encoded by the TOP2A gene on chromosome 17q21 22 , and human topoisomerase IIbeta ( TOP2B ) is encoded by the TOP2B gene on chromosome 3p24 . ^^^ In the present study , we have defined the intron exon structures of TOP2A and TOP2B . ^^^ TOP2A is approx . 30kb whereas TOP2B is at least 49kb . ^^^ TOP2A and TOP2B contain 35 and 36 exons , respectively , and both genes contain a high proportion of class 0 introns . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| Human top2alpha promoted cleavage patterns that were much more similar to those of Drosophila top 2 ( both in vitro and in vivo ) than human top2beta . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| The two human topo 2 proteins are encoded by the TOP2A and TOP2B genes , respectively , which despite their highly conserved structural organization , are subject to distinctly different modes of regulation . ^^^ We found that the promoter activity of this TOP2B fragment was constant throughout the cell cycle , in contrast to the activity of the proximal promoter of TOP2A which was low in resting cells and enhanced during proliferation . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that the topoisomerase 2 ( TOP 2 ) beta DNA covalent complex arrests transcription and triggers 26S proteasome mediated degradation of TOP2beta . ^^^ These results suggest that proteasomal degradation of TOP2beta induced by the TOP 2 DNA covalent complex or the TOP 2 circular clamp is due to transcriptional arrest but not DNA damage . ^^^ |
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| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02880 and P11388 |
Pubmed |
SVM Score :0.0 |
| NA |
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