| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| A protein called MP 1 ( MEK Partner 1 ) was identified that bound specifically to MEK 1 and ERK 1 and facilitated their activation . ^^^ Expression of MP 1 in cells increased binding of ERK 1 to MEK 1 . ^^^ |
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| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| The scaffold protein MP 1 ( MEK 1 partner ) assembles a scaffold complex in the ERK cascade . ^^^ |
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| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Mapping of highly conserved , surface exposed residues on MP 1 and p 14 provided insight into the potential sites of binding of the signaling kinases MEK 1 and ERK 1 to this complex , as well as the areas potentially involved in other protein protein interactions . . ^^^ |
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| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the interactions of MP 1 with the ERK pathway , we analyzed the ability of MP 1 to bind to MEK 1 , ERK 1 , and to itself , and the regulation of these interactions . ^^^ An MP 1 mutant that lost MEK 1 binding no longer enhanced RasV 12 stimulated ERK 1 activity , and functioned as a dominant negative , consistent with the concept that MP 1 function depends on facilitating these oligomerizations . ^^^ These results support the concept that MP 1 functions as a regulator of MAP kinase signaling by binding to MEK 1 and regulating its association with a larger signaling complex that may sequentially service multiple molecules of ERK . . ^^^ |
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| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein p 14 is associated with the cytoplasmic face of late endosomes that is involved in cell surface receptor endocytosis and it also directly interacts with MP 1 , a scaffolding protein that binds the MAP kinase ERK 1 and its upstream kinase activator MEK 1 . ^^^ The interaction of p 14 with MP 1 recruits the latter to late endosomes and the endosomal localization of p14 / MP1 MEK 1 ERK1 scaffolding complex is required for signaling via ERK MAP kinase in an efficient and specific manner upon receptor stimulation . ^^^ |
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| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| The MEK 1 scaffolding protein MP 1 regulates cell spreading by integrating PAK 1 and Rho signals . ^^^ MP 1 associates with active but not inactive PAK 1 and controls PAK 1 phosphorylation of MEK 1 . ^^^ Our data further show that MP 1 , p 14 , and MEK 1 serve to inhibit Rho / Rho kinase functions necessary for the turnover of adhesion structures and cell spreading and reveal a signal channeling function for a MEK1 / ERK scaffold in orchestrating cytoskeletal rearrangements important for cell motility . . ^^^ |
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| Interacting proteins: Q9UHA4 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
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