| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| The components of this assay include human cRaf 1 , MEK 1 , and ERK 2 and a biotinylated peptide substrate for ERK 2 . cRaf 1 was expressed as a his tagged protein in insect cells in an active form . ^^^ When the purified components are incubated together , cRaf 1 phosphorylates and activates MEK 1 , MEK 1 phosphorylates and activates ERK 2 , and ERK 2 phosphorylates the peptide , biotin AAATGPLSPGPFA . ^^^ The assay detects inhibitors of cRaf 1 , MEK 1 , or ERK 2 , and has been used to screen large numbers of compounds . ^^^ |
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| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| We report here that CD 40 induced TRAF 3 dependent activation of mitogen activated protein kinase ( MAPK ) / extracellular signal regulated kinase ( ERK ) kinase 1 ( MEK 1 ) is involved in the upregulation of IL 4 driven germline C epsilon transcription in a human Burkitt ' s lymphoma B cell line , DG 75 . ^^^ Antisense oligodeoxynucleotide ( ODN ) for TRAF 3 inhibited CD 40 induced activation of MEK 1 ERK pathway by decreasing expression of TRAF 3 protein , but antisense ODNs for TRAF 2 , 5 , and 6 were ineffective . ^^^ Furthermore , CD 40 mediated enhancement of IL 4 driven germline C epsilon transcription was inhibited by antisense ODN for TRAF 3 and by a MEK 1 inhibitor , PD 98059 . ^^^ These results suggest that in DG 75 cells , TRAF 3 induced MEK 1 activation may be involved in CD 40 mediated upregulation of IL 4 driven germline C epsilon transcription . . ^^^ |
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| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02750 and Q13114 |
Pubmed |
SVM Score :0.0 |
| NA |
|