| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| This is paralleled by the stimulation of MEK 1 and MAP kinase activity and by the phosphorylation of the transcription factor Elk 1 , a nuclear target of MAP kinase . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Constitutively active MAPKK 1 fully activates ERK 2 and the transcription factor Elk 1 , but does not substitute for activated p21ras and synergize with calcium / calcineurin signals to induce NFAT . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Using the Jurkat T lymphocyte cell line , we found that a stably expressed Gi protein coupled receptor ( the delta opioid receptor ( DOR 1 ) ) stimulates MEK 1 and extracellular signal regulated kinases 1 and 2 ( ERK 1 and ERK 2 ) and transcriptional activity by an ERK target , Elk 1 , via a mechanism requiring a PTX sensitive Gi protein . ^^^ Levels of beta adrenergic receptor kinase 1 C terminal fragment that inhibited signaling by Gi protein beta gamma subunits in these cells had no effect on DOR 1 stimulation of either MEK 1 or Elk 1 dependent transcription , indicating that this pathway is independent of beta gamma . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| However , a specific MEK 1 inhibitor , PD 98059 , significantly decreased TGF beta 1 induced Elk 1 phosphorylation in a dose dependent manner . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Interestingly , stimulation of Elk 1 transcriptional activity by MEK 1 , a p42 / p44 MAPK kinase , was significantly enhanced in cells overexpressing PKCzeta . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Altered regulation of ERK1b by MEK 1 and PTP SL and modified Elk 1 phosphorylation by ERK1b are caused by abrogation of the regulatory C terminal sequence of ERKs . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Furthermore , tyrosine phosphorylation of FAK and phosphotyrosine kinase ( Pyk ) 2 ; serine phosphorylation of c Raf , MEK 1 , and Elk 1 ; and tyrosine threonine phosphorylation of Erk 1 and 2 were time dependently activated in the presence of GDNF . ^^^ More specifically , the Ras inhibitor manumycin inhibited phosphorylation of c Raf , MEK 1 , Erk 1 and 2 , and Elk 1 , but not that of FAK . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| The GM CSF promoted cell survival and proliferation correlated with MEK 1 dependent ERK1 / 2 , Elk 1 and CREB phosphorylation and Egr 1 , c Fos expression as well as with increased STAT 5 , AP 1 , c Myb and NF kappaB DNA binding . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| While investigating the upstream signaling pathways , we found that ERK1 / 2 MAPK is activated and translocates to the nucleus to activate Elk 1 , and inhibition of the activation of ERK by specific inhibitors of MEK 1 blocks the up regulation of VEGF by low pH . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the antiproliferative effects of estrogen in RASMCs involved ERK inhibition followed by the inactivation of MEK 1 , 2 and downregulation of Elk 1 expression . . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| In the present study , we show that peptides corresponding to the MAPK docking sites of MEK 1 , MEK 2 , Ste 7 , Elk 1 and MAPK phosphatase ( MKP ) 2 potently inhibit MEK 2 phosphorylation of ERK 2 , ERK 2 phosphorylation of Elk 1 , and MKP 1 dephosphorylation of ERK 2 . ^^^ |
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| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| There is evidence indicating that the CD site and the substrate binding region defined here are also utilized for MEK 1 recognition , and indeed , we demonstrate that the binding of MKP 3 , Elk 1 , and MEK 1 to ERK 2 is mutually exclusive . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Using a constitutively active Mek 1 to bypass the regulation of Raf by Akt , we find that the Elk 1 and Sap1a proteins are dramatically decreased in the presence of activated Akt . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| The novel hybrid transcription factor TetR Elk 1 was regulated by MAPK ERK kinase 1 ( MEK 1 ) overexpression , and TetR CREB was regulated by protein kinase A ( PKA ) overexpression or elevation of cyclic AMP levels . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Pharmacological inhibitor studies as well as reporter assays for ERK dependent activation of the transcription factor Elk 1 revealed that the PP2A holoenzymes ABalphaC and ABdeltaC act downstream of Ras and upstream of MEK 1 to promote activation of this MAPK signaling cascade . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| The authors have developed and run a high throughput screen to find inhibitors of V600E BRAF using an enzyme cascade assay in which oncogenic BRAF activates MEK 1 , which in turn activates ERK 2 , which then phosphorylates the transcription factor ELK 1 . ^^^ These compounds did not inhibit a shortened activated MEK 1 to ELK 1 cascade but were active ( 0 . 5 27 . 9 microM ) in a V600E BRAF assay and represent a potential starting point for future drug discovery and development . . ^^^ |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19419 and Q02750 |
Pubmed |
SVM Score :0.0 |
| NA |
|