| Interacting proteins: O15519 and Q02750 |
Pubmed |
SVM Score :0.0 |
| We further demonstrated that activation of MKK 1 led to expression of FLIP , a specific inhibitor of FADD . ^^^ MKK 1 inhibition of FADD induced cell death was abrogated if induction of FLIP was prevented , indicating that FLIP mediates MKK 1 suppression of FADD mediated apoptosis . ^^^ |
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| Interacting proteins: O15519 and Q02750 |
Pubmed |
SVM Score :0.0 |
| Although FLIP expression is regulated primarily by MEK 1 activity in activated T cells , the oncogenic signaling pathways that regulate FLIP expression in tumor cells are largely unknown . ^^^ We observed that the MEK 1 inhibitor PD 98059 reduced FLIP levels in only 2 of 11 tumor cell lines tested . ^^^ |
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