| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| Pax 5 recruits Ets 1 to bind the promoter , but not the closely related Ets protein SAP1a . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| Others , such as Pax 5 , alter Ets 1 DNA binding properties . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| By tethering deletion fragments of Pax 5 to a heterologous DNA binding domain , we show that 73 amino acids ( amino acids 12 to 84 ) of its amino terminal subdomain can recruit the ETS domain of Ets 1 to bind the composite site . ^^^ Furthermore , an amino acid ( Gln 22 ) within the highly conserved beta hairpin motif of Pax 5 is essential for efficient recruitment of Ets 1 . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| The structure of the ETS domain of Ets 1 and the paired domain of Pax 5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax 5 . ^^^ Comparison with structures of Ets 1 alone bound to both high and low affinity DNA sites reveals that Pax 5 alters the Ets 1 contacts with DNA . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| Ets 1 flips for new partner Pax 5 . ^^^ The newest Ets 1 partner Pax 5 directs a surprising conformational change that maximizes the protein interface and changes binding site preference . . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| Pax 5 recruits three members of the Ets family of transcription factors : Ets 1 , Fli 1 and GABPalpha ( with GABPbeta 1 ) , to assemble ternary complexes on the mb 1 promoter in vitro . ^^^ Using the Pax 5 : Ets 1 : DNA crystal structure as a guide , we defined amino acid requirements for transcriptional activation of endogenous mb 1 genes using a novel cell based assay . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| The present study analyzed the expression of the following 13 TFs : AML 1 , CEBPA , E2A , ETS 1 , GATA 1 , GATA 2 , GATA 3 , IKAROS , IRF 1 , PAX 5 , PU 1 , TBET and TCF 1 in 7 malignant NK cell lines together with 5 malignant NKT cell lines , 5 T cell acute lymphoblastic leukemia ( ALL ) cell lines including 3 gamma / delta T cell receptor ( TCR ) type and 2 alpha / beta TCR type , and 3 B cell precursor ( BCP ) leukemia cell lines . ^^^ |
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| Interacting proteins: Q02548 and P14921 |
Pubmed |
SVM Score :0.0 |
| To investigate the roles of TFs in human B cell precursors ( BCPs ) , the present study analyzed the expression of the following 16 hematopoietic TFs : AML 1 , C / EBPalpha , C / EBPbeta , C / EBPgamma , C / EBPepsilon , E2A , Ets 1 , GATA 1 , GATA 2 , GATA 3 , Ikaros , IRF 1 , Pax 5 , PU . 1 , T bet and TCF 1 in 30 human BCP leukemia cell lines . ^^^ All BCP leukemia cell lines were found to be positive for the expression of AML 1 , C / EBPgamma , E2A , Ets 1 , IRF 1 , Pax 5 and PU . 1 at the mRNA level . ^^^ |
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