| Interacting proteins: Q02548 and P10242 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q02548 and P10242 |
Pubmed |
SVM Score :0.0 |
| Our work and that of others subsequently revealed that RAG 2 promoter expression is positively regulated by BSAP ( PAX 5 ) and c Myb transcription factors in B and T lineage cells , respectively . ^^^ Although BSAP and c Myb were deemed necessary for lymphocyte specific expression , our analysis also uncovered a G rich region at the 5 ' end of the core promoter that was essential for full activity in lymphocyte cell lines . ^^^ |
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| Interacting proteins: Q02548 and P10242 |
Pubmed |
SVM Score :0.0 |
| Cooperative binding of c Myb and Pax 5 activates the RAG 2 promoter in immature B cells . ^^^ The region contained 2 cis elements that bound c Myb and Pax 5 . ^^^ Cooperative activation of the RAG 2 promoter was seen by a combination of c Myb and Pax 5 in a human embryonic kidney cell line ( 293T ) , via their synergistic DNA binding . ^^^ These results suggest that cooperative binding of c Myb and Pax 5 to the RAG 2 promoter is one of the mechanisms to direct the restricted expression of the RAG 2 in immature B cells . . ^^^ |
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| Interacting proteins: Q02548 and P10242 |
Pubmed |
SVM Score :0.0 |
| Lymphoid enhancer binding factor 1 binds and activates the recombination activating gene 2 promoter together with c Myb and Pax 5 in immature B cells . ^^^ We studied the regulation of murine RAG 2 promoter and revealed that 41 / 17 RAG 2 promoter region , which was indispensable for the RAG 2 promoter activity in B cell lines , contained binding sites for lymphoid enhancer binding factor 1 ( LEF 1 ) , c Myb , and Pax 5 . ^^^ Cotransfection assays using a human embryonic kidney cell line ( 293T ) showed that LEF 1 , c Myb , and Pax 5 cooperatively activated the RAG 2 promoter , via their synergistic DNA binding . ^^^ We also showed that LEF 1 , c Myb , and Pax 5 physically interact in the cells . ^^^ These results suggest that LEF 1 / beta catenin complex regulates the RAG 2 promoter activation in concert with c Myb and Pax 5 in immature B cells . ^^^ |
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| Interacting proteins: Q02548 and P10242 |
Pubmed |
SVM Score :0.0 |
| Moreover , we also show that Egr 1 forms a complex with other redox sensitive transcription factors ( e . g . , AP 1 , AP 2 , NFATc , Sp 1 , PAX 5 , MTF 1 , c Myb , and CREB ) in rat duodenal mucosa and that cysteamine enhances the formation of these complexes . ^^^ |
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