| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 2 beta 1 is a positive regulator of collagenase ( MMP 1 ) and collagen alpha 1 ( 1 ) gene expression . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| Here , we have studied in human KHOS 240 and MG 63 osteosarcoma cells and in human skin fibroblasts the effects of tyrosine kinase inhibitors on collagen gel contraction and on the regulation of MMP 1 and collagen alpha 1 ( 1 ) genes by extracellular collagen . ^^^ Thus , the collagen induced alterations in the expression of MMP 1 and collagen alpha 1 ( 1 ) seem to be dependent on distinct signal transduction pathways . ^^^ Thus , we suggest that the process of collagen gel contraction requires protein tyrosine phosphorylation and that the ability of cells to contract collagen gels is not related to the induction of MMP 1 or to the level of collagen alpha 1 ( 1 ) expression . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated that halofuginone , a widely used alkaloid coccidiostat , is a potent inhibitor of collagen alpha 1 ( 1 ) and matrix metalloproteinase 2 gene expression . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| Left ventricular ( LV ) mRNA [ MMP 1 , 2 , 3 , 7 , 9 , 11 , 13 , 14 ; TIMP 1 , 2 , 3 , 4 ; and collagen alpha 1 ( 1 ) and alpha 1 ( 3 ) ] and protein ( MMP 2 and MMP 9 zymographic activity ; Western blot analysis of MMP 13 , and TIMP 1 , 2 , 4 ) levels could be quantified . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated that halofuginone , a low molecular weight quinazolinone alkaloid , is a potent inhibitor of collagen alpha 1 ( 1 ) and matrix metalloproteinase 2 ( MMP 2 ) gene expression . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| MMP 2 activation by these cultures was blocked by inhibitors of prolyl 4 hydroxylase , or when fibroblasts derived from the collagen alpha 1 ( 1 ) gene deficient Mov 13 mouse were used . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| Halofuginone , a widely used alkaloid coccidiostat , is a potent inhibitor of collagen alpha 1 ( 1 ) and matrix metalloproteinase 2 gene expression . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| Genes that are involved in the modulation of extracellular proteins : tropomyosin , collagen alpha 1 , MMP 1 , MMP 19 , and connective tissue growth factor . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| Collagen alpha 1 ( 6 ) , collagen alpha 2 ( 1 ) , fibronectin , lumican , and matrix metalloproteinase 2 were among the proteins consistently detected from control and H2O2 treated cells . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNA expressions of collagen alpha 1 ( 1 ) , MMP 1 , TIMP 1 , TGF beta 1 were not changed by 17beta estradiol stimulations at a concentration of 10 ( 12 ) to 10 ( 8 ) M . ^^^ |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P08253 |
Pubmed |
SVM Score :0.0 |
| NA |
|