| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Two cyanogen bromide peptides of the collagen alpha 1 ( 2 ) chain , CB 8 and CB 12 , derived from different parts of the chain , were active in fibronectin binding . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Changes similar to those observed for fibronectin mRNA , although of different magnitudes , were observed in mRNA levels for collagen alpha 1 ( 3 ) and beta 1 integrin . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| GH dependent reduction of levels of collagen alpha 1 ( 1 ) mRNA expression occurred later and was less pronounced than effects on levels of fibronectin mRNA , suggesting a specificity in the matrix altering function of GH . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Steady state mRNA levels of collagen alpha 1 ( 1 ) and alpha 1 ( 3 ) , collagenase , fibronectin , and beta actin were studied using specific cDNA probes and compared to those of 12 sex and age matched healthy individuals . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Neointima formation and TGF beta 1 immunoreactivity were correlated with increases in fibronectin , collagen alpha 2 ( 1 ) , and collagen alpha 1 ( 3 ) gene expression . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| The effect of TGF beta 1 on the expression of the basement membrane genes , fibronectin , laminin B 1 , and collagen alpha 1 ( 4 ) , was examined . ^^^ Treatment of these differentiated cells with TGF beta 1 induced the expression of fibronectin mRNA to levels seen in TGF beta treated , undifferentiated keratinocytes but only marginally increased the expression of collagen alpha 1 ( 4 ) and laminin B 1 mRNA . ^^^ The inclusion of cycloheximide in the protocol indicated that TGF beta induction of collagen alpha 1 ( 4 ) mRNA was signaled by proteins already present in the cells but that TGF beta required the synthesis of a protein ( s ) to fully induce expression of fibronectin and laminin B 1 mRNA . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| The current data are interpreted as follows . ( 1 ) The ability of the liver endothelial cells and the Kupffer cells to sequester circulating 125I alpha 1 efficiently may indicate a physiological pathway for the breakdown of connective tissue collagen . ( 2 ) The liver endothelial cells express receptors that specifically recognize and mediate the endocytosis of collagen alpha 1 ( 1 ) monomers . ( 3 ) The receptors also recognize denatured collagen ( gelatin ) . ( 4 ) Fibronectin is not involved in the binding of alpha 1 to the receptors . ( 5 ) Degradation occurs intralysosomally by leupeptin inhibitable cathepsins . . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to identify the cell types that express collagen alpha 1 ( 1 ) , alpha 1 ( 3 ) and alpha 1 ( 4 ) , fibronectin and laminin B 1 genes in normal rat liver . ^^^ Fibronectin and collagen alpha 1 ( 3 ) mRNAs were detected in total RNA of purified parenchymal cells . ^^^ In total RNA of freshly isolated fat storing cells , collagen alpha 1 ( 3 ) , alpha 1 ( 4 ) , and laminin B 1 transcripts were found , whereas collagen alpha 1 ( 1 ) and fibronectin mRNAs were not detected . ^^^ Cultured fat storing cells , however , did contain high levels of collagen alpha 1 ( 1 ) and fibronectin mRNAs . ^^^ When fat storing cells are allowed to differentiate into myofibroblast like cells , they express high levels of collagen alpha 1 ( 1 ) and fibronectin mRNAs , in addition to collagen alpha 1 ( 3 ) and alpha 1 ( 4 ) , and laminin B 1 chain mRNAs . . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Dexamethasone stimulated the expression of collagen alpha 1 ( 4 ) , fibronectin , and laminin B 1 mRNA levels by 1 . 4 , 2 . 4 , and 1 . 6 fold respectively , in primary fat storing cells . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we investigated the effect of CsA on the expression of collagen alpha 1 ( 1 ) , fibronectin and matrix metalloprotease 1 genes in dermal fibroblasts from untreated donors . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| KRH 594 ( 10 mg / kg / day ) also suppressed the injury induced gene expressions for transforming growth factor beta 1 and fibronectin and reduced collagen alpha 1 ( 1 ) and alpha 1 ( 3 ) mRNA levels for the first 7 days after injury . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Significant increases in mRNA for fibronectin ( 7 . 5 fold , P < 0 . 01 ) , heparan sulfate proteoglycan core protein ( 53 fold , P < 0 . 001 ) , laminin beta 1 ( 12 fold , P < 0 . 001 ) , collagen alpha 1 ( 4 ) ( 17 fold , P < 0 . 001 ) , collagen alpha 1 ( 3 ) ( fourfold , P < 0 . 001 ) , and MMP 9 ( twofold , P < 0 . 05 ) were observed after perfusion with TGF beta 1 . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNAs encoding TGF beta 1 ( in both mouse and human ) , entactin , fibronectin , and the collagen alpha 1 ( 4 ) and alpha 2 ( 4 ) chains were significantly induced in total kidney as a function of Alport renal disease progression . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed overexpression of collagen alpha 1 ( 4 ) mRNA and fibronectin mRNA in OBKs . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Functional HGF receptors were deed in MMC by HGF induced extracellular acidification , a response that was inhibited by the HGF inhibitor HGF / NK2 , a splice variant expressing the N terminal domain through the second kringle domain HGF also increased fibronectin and collagen alpha 1 ( 4 ) mRNA levels in these cells ; the increases were associated with a concentration dependent increase in transcriptional activity of the collagen alpha 1 ( 4 ) gene . ^^^ HGF also stimulated fibronectin and collagen alpha 1 ( 4 ) mRNA levels in primary rabbit proximal tubule epithelial cells To evaluate the potential consequences of chronic elevation of HGF on renal fuction , HGF was administered continuously for 18 days to normal and diabetic C57BLKS / J lepr ( db ) mice . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| In this study , an endothelin antagonist was used to assess the effects of endothelin blockage on the production of two basement membrane transcripts , fibronectin and collagen alpha 1 ( 4 ) . ^^^ Semiquantitative reverse transcription polymerase chain reaction for fibronectin and collagen alpha 1 ( 4 ) was conducted after 1 month of follow up with comparison to beta actin housekeeping gene using slot blot hybridization and densitometry . ^^^ After 1 month of follow up , increased fibronectin and collagen alpha 1 ( 4 ) mRNA were present in the retina of diabetic and galactosemic animals , and the bosentan treated groups exhibited mRNA levels similar to the control animals . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| In keeping with focal fibrosis , myocardium from diabetic rats further showed significantly increased mRNA expression of two extracellular matrix protein transcripts , fibronectin and collagen alpha 1 ( 4 ) which were completely prevented by treatment with bosentan . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Ang 2 increased both collagen alpha 1 ( 92 % , SEM + / 20 % ) mRNA expression and fibronectin ( 21 % + / 6 % ) protein synthesis in static VSM cells compared with unstimulated controls . ^^^ Similarly , mechanical strain induced an increase in both collagen alpha 1 ( 102 % + / 30 % ) mRNA expression and fibronectin ( 50 % + / 21 % ) protein synthesis . ^^^ |
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| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| In primary cultured stellate cells , TJ 135 suppressed DNA synthesis and the expression of collagen alpha 1 ( 1 ) , collagen 3 , and fibronectin mRNAs . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Collagen alpha 1 ( 6 ) , collagen alpha 2 ( 1 ) , fibronectin , lumican , and matrix metalloproteinase 2 were among the proteins consistently detected from control and H2O2 treated cells . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that IL 10 gene therapy attenuated liver TGF beta 1 , collagen alpha 1 , fibronectin , and cell adhesion molecule mRNA upregulation . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| Identification of COL7A1 alternative splicing inserting 9 amino acid residues into the fibronectin type 3 linker domain . ^^^ |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02388 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|