| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| The neuronal cell adhesion molecule axonin 1 is composed of six immunoglobulin and four fibronectin type 3 domains . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Comm ) or vertebrates ( e . g . axonin 1 and NrCAM ) . . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| The human TAX 1 gene ( HGMW approved symbol TAX 1 ) is located on chromosome 1 ( 1q32 . 1 ) and encodes the neuronal cell adhesion molecule TAG 1 / axonin 1 . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| The neuronal cell adhesion molecule axonin 1 is specifically released by an endogenous glycosylphosphatidylinositol specific phospholipase . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| The neuronal cell adhesion molecule , TAG 1 , is transiently expressed on PF axons in the deep EGL ( Yamamoto et al . [ 1986 ] J . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Nr CAM is a neuronal cell adhesion molecule ( CAM ) belonging to the immunoglobulin superfamily that has been implicated as a ligand for another CAM , axonin 1 , in guidance of commissural axons across the floor plate in the spinal cord . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| In rSey2 / rSey2 fetuses , cortical efferent axons develop with normal trajectory , at least within the cortical anlage , when examined with immunohistochemistry of the neuronal cell adhesion molecule TAG 1 and 1 , 1 ' dioctadecyl 3 , 3 , 3 ' , 3 ' tetramethylindocarbocyanine perchlorate ( DiI ) labeling from the cortical surface . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Involvement of gangliosides in glycosylphosphatidylinositol anchored neuronal cell adhesion molecule TAG 1 signaling in lipid rafts . ^^^ The association of ganglioside GD 3 with TAG 1 , a glycosylphosphatidylinositol anchored neuronal cell adhesion molecule , was examined by coimmunoprecipitation experiments . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| A direct interaction of axonin 1 with NgCAM related cell adhesion molecule ( NrCAM ) results in guidance , but not growth of commissural axons . ^^^ An interaction of growth cone axonin 1 with the floor plate NgCAM related cell adhesion molecule ( NrCAM ) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Binding between the neural cell adhesion molecules axonin 1 and Nr CAM / Bravo is involved in neuron glia interaction . ^^^ Here we report on an interaction between axonin 1 and Nr CAM / Bravo . ^^^ By antibody blockage experiments an axonin 1 receptor on the glial cells was identified as Nr CAM . ^^^ The specificity of the interaction was confirmed with binding studies using purified axonin 1 and Nr CAM . ^^^ In cultures of dissociated dorsal root ganglia antibodies against axonin 1 and Nr CAM perturbed the formation of contacts between neurites and peripheral glial cells . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Axonin 1 , Nr CAM , and Ng CAM play different roles in the in vivo guidance of chick commissural neurons . ^^^ The present in vivo study demonstrates that interactions by two of these molecules , axonin 1 on commissural growth cones and Nr CAM on floor plate cells , are required for accurate pathfinding at the midline . ^^^ When axonin 1 or Nr CAM interactions were perturbed , many commissural axons failed to cross the midline and turned instead along the ipsilateral floor plate border . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| CHL 1 is most similar in its extracellular domain to chicken Ng CAM ( approximately 40 % amino acid identity ) , followed by mouse L 1 , chicken neurofascin , chicken Nr CAM , Drosophila neuroglian and zebrafish L1 . 1 ( 37 28 % amino acid identity ) , and mouse F 3 , rat TAG 1 and rat BIG 1 ( approximately 27 % amino acid identity ) . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Interference with axonin 1 and NrCAM interactions unmasks a floor plate activity inhibitory for commissural axons . ^^^ Axonin 1 and NrCAM were previously shown to be involved in the in vivo guidance of commissural growth cones across the floor plate of the embryonic chicken spinal cord . ^^^ Although commissural axons readily entered the floor plate under control conditions , perturbations of either axonin 1 or NrCAM interactions prevented the growth cones from entering the floor plate explants . ^^^ Therefore , axonin 1 and NrCAM are crucial for the contact mediated interaction between commissural growth cones and the floor plate , which in turn is required for the proper guidance of the axons across the ventral midline and their subsequent rostral turn into the longitudinal axis . . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| In addition to NrCAM , we here demonstrate that neurofascin also binds to the extracellular matrix glycoprotein tenascin R ( TN R ) and to the Ig superfamily members axonin 1 and F 11 . ^^^ In vitro neurite outgrowth and cell attachment assays on a neurofascin Fc substrate reveal a shift of cellular receptor usage from NrCAM to axonin 1 , F 11 , and at least one additional protein in the presence of TN R , presumably due to competition of the neurofascin NrCAM interaction . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| In addition , we provide evidence that interactions between commissural axons and floor plate cells are required to modulate the localization of Nr CAM and TAG 1 proteins on axons at the midline . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Axonin 1 , NgCAM , and NrCAM , three members of the immunoglobulin ( Ig ) superfamily of cell adhesion molecules ( CAMs ) , were shown to be important for the correct growth pattern of commissural axons . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Binding experiments with Fc chimeric proteins revealed that TAG 1 interacts with L 1 , NrCAM , and F3 / contactin . ^^^ Furthermore we investigated the putative role of L 1 and NrCAM as the neuronal TAG 1 receptors mediating neurite extension . ^^^ DRG neurons from L 1 deficient mice were found to extend neurites on TAG 1 substrates and blocking NrCAM function did not diminish the TAG 1 dependent neurite outgrowth . ^^^ These results indicate that neither L 1 nor NrCAM are required for TAG 1 elicited neurite outgrowth . . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Nr CAM and TAG 1 are expressed in distinct populations of developing precerebellar and cerebellar neurons . ^^^ Nr CAM and TAG 1 interact at the floor plate during the formation of spinal cord commissural projections [ Stoeckli , E . ^^^ Nr CAM and Tag 1 label distinct populations of precerebellar neurons at key steps of their development . ^^^ These results emphasize the possibility that TAG 1 / Nr CAM interactions are also involved in the development of the cerebellar system ( precerebellar and cerebellar neurons ) . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| The approach included an immunohistological analysis of the temporal and spatial expressions of choline acetyltransferase , of the neural glial related and neural glial cell adhesion molecules ( NrCAM and NgCAM , respectively ) and axonin 1 , and of inwardly rectifying potassium ( Kir ) channels in 5 to 19 day old ( E 5 E19 ) embryos . ^^^ |
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| Interacting proteins: Q92823 and Q02246 |
Pubmed |
SVM Score :0.0 |
| Using optical tweezers and single particle tracking of beads coated with the ligand TAG 1 , we analyzed the mobility of NrCAM deletion mutants transfected in a neuroblastoma cell line . ^^^ Photobleaching experiments showed that the lateral mobility of NrCAM increased with raft dispersion in these contact areas , further suggesting that TAG 1 coated beads induced the coalescence of lipid rafts . ^^^ |
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