| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| There is some controversy regarding the precise mechanism of upregulation of XPE DDB 2 or XPC by BRCA 1 , with some evidence suggesting that p 53 is involved in their regulation . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| The mechanism by which p 53 regulates NER may be through its ability to act as a transcription factor , and / or through direct interactions with damaged DNA or the repair machinery . p 53 has been shown to regulate the expression of the DDB 2 gene ( encoding the p 48 protein ) and the XPC gene , two important components of the NER pathway involved in DNA damage recognition . ^^^ We propose that p 53 functions to transcriptionally regulate the DDB 2 and XPC NER genes , but does not activate the NER pathway through direct interactions with UV induced damaged DNA or other repair factors . . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Induction of DDB 2 , CDKN1A ( also known at C1P1 / WAF1 ) and XPC showed a linear dose response relationship between 0 . 2 and 2 Gy at 24 and 48 h after irradiation , with less linearity at earlier or later times . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Here we show that BRCA 1 specifically enhances the GGR pathway , independent of p 53 , and can induce p 53 independent expression of the NER genes XPC , DDB 2 , and GADD 45 . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| In vivo recruitment of XPC to UV induced cyclobutane pyrimidine dimers by the DDB 2 gene product . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Although several theories have been proposed , accumulating evidence points to a transcriptional regulatory role for p 53 in NER , mediating expression of the global genomic repair ( GGR ) specific damage recognition genes , DDB 2 and XPC . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| UV radiation induced XPC translocation within chromatin is mediated by damaged DNA binding protein , DDB 2 . ^^^ Here , we have examined the influence of p 53 and damaged DNA binding complex ( DDB 2 ) proteins on the distribution of XPC within damaged chromatin in vivo and the recruitment of XPC to DNA damage sites in situ . ^^^ The UV radiation induced redistribution of XPC was equally compromised in p 53 deficient , as well as DDB 2 deficient , human cells . ^^^ Ectopic expression of DDB 2 in p 53 deficient cells overcame the requirement of p 53 function for UV induced translocation of XPC in vivo . ^^^ Restoration of DDB 2 function also enhanced the recruitment of XPC to DNA damage sites in situ and increased the global repair of cyclobutane pyrimidine dimer from the genome . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| The mechanisms involved in this process include both transcriptional and post translational regulation by p 53 of the DDB 2 and XPC gene products , two critical DNA damage recognition proteins required for GGR . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| By using several NER deficient cell lines , we found that DDB 2 and XPA are required for UV induced XPC modifications . ^^^ Taken together , we conclude that XPC protein is modified by SUMO 1 and ubiquitin following UV irradiation and these modifications require the functions of DDB 2 and XPA , as well as the ubiquitin proteasome system . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Basal levels of mRNA encoding the DNA damage recognition proteins , XPC and DDB 2 , were relatively insensitive to differentiation and p 53 levels . ^^^ However , following ultraviolet radiation , inductions of mRNA encoding the DNA damage recognition proteins , DDB 2 and XPC , were differentially affected by differentiation . ^^^ Rapid loss of DDB 2 mRNA induction was associated with differentiation , while XPC mRNA induction diminished more slowly with differentiation . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we found several genes associated with DNA repair namely p53R2 , DDB 2 , XPC , PCNA , BTG 2 , and MSH 2 that were highly induced in TK 6 compared to WTK 1 and NH 32 . p53R2 , which is regulated by the tumor suppressor p 53 , is a small subunit of ribonucleotide reductase . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Cullin 4A mediated proteolysis of DDB 2 protein at DNA damage sites regulates in vivo lesion recognition by XPC . ^^^ Here , we have provided evidence that Cullin 4A ( CUL 4A ) , a key component of CUL 4A based ubiquitin ligase , mediates DDB 2 degradation at the damage sites and regulates the recruitment of XPC and the repair of cyclobutane pyrimidine dimers . ^^^ CUL 4A was visualized in localized UV irradiated sites together with DDB 2 and XPC . ^^^ These results suggest that CUL 4A mediates the proteolytic degradation of DDB 2 and that this degradation event , initiated at the lesion sites , regulates damage recognition by XPC during the early steps of NER . . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| Evaluation of xeroderma pigmentosum XPA , XPC , XPD , XPF , XPB , XPG and DDB 2 genes in familial early onset lung cancer predisposition . ^^^ To formally investigate the role of XP related NER genes in lung cancer susceptibility , we screened germline DNA from 92 familial early onset lung cancer patients for mutations in all coding regions and intron exon boundaries of XPA , XPC , XPD , XPF , XPB , XPG and DDB 2 . ^^^ |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92466 and Q01831 |
Pubmed |
SVM Score :0.0 |
| NA |
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