| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| Recently , we reported the cloning and analysis of three human NER genes , XPC , HHR23A , and HHR23B . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| Consistent with a function in repair or DNA / chromatin metabolism , immunofluorescence studies show all XPC , HHR23B and ( the free ) HHR23A to reside in the nucleus . . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| However , a number of mammalian DNA repair proteins lack NLS clusters ; these proteins include ERCC 1 , ERCC 2 ( XPD ) , mouse RAD 51 , and the HHR23B / p58 and HHR23A subunits of XPC . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| XPC interacts with both HHR23B and HHR23A in vivo . ^^^ Here , we show that XPC interacts in vivo , by means of the yeast two hybrid system , with both HHR23B and a second homologue of RAD 23 , HHR23A . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that not only highly purified recombinant hHR23B ( rhHR23B ) but also a second human homolog of the Saccharomyces cerevisiae Rad 23 repair protein , hHR23A , stimulates the in vitro repair activity of recombinant human XPC ( rhXPC ) , revealing functional redundancy between these human Rad 23 homologs . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction . ^^^ The two human homologs of Rad 23 , hHR23A and B , are functionally redundant in NER and interact with xeroderma pigmentosum complementation group C ( XPC ) protein . ^^^ The interaction of the XPC binding domain ( XPCB ) of hHR23A / B with XPC protein has been shown to be important for its optimal function in NER . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| Human cells contain two homologs of the yeast RAD 23 protein , hHR23A and hHR23B , which participate in the DNA repair process . hHR23B houses a domain ( residues 277 332 , called XPCB ) that binds specifically and directly to the xeroderma pigmentosum group C protein ( XPC ) to initiate nucleotide excision repair ( NER ) . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| HHR23A and hHR23B are the human homologs of Saccharomyces cerevisiae Rad 23 . hHR23B is associated with the nucleotide excision repair ( NER ) factor xeroderma pigmentosum C ( XPC ) protein and is required for global genome repair . ^^^ In these hHR23A ( KD ) cells , the XPC gene was not normally induced by UVC irradiation , indicating that the hHR23A protein is involved in NER through regulation of the DNA damage recognition protein XPC . ^^^ Co immunoprecipitation experiments revealed that hHR23A was associated with a small portion of hHR23B and the majority of p 53 protein , indicating that hHR23A regulates the function of XPC by its association with the NER activator p53 . . ^^^ |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01831 and P54725 |
Pubmed |
SVM Score :0.0 |
| NA |
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