| Interacting proteins: Q01826 and P55212 |
Pubmed |
SVM Score :0.0 |
| In support of this model , the transcriptional suppressor special AT rich sequence binding protein 1 , a preferred caspase 6 substrate , was cleaved upon B cell stimulation . ^^^ |
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| Interacting proteins: Q01826 and P55212 |
Pubmed |
SVM Score :0.0 |
| Transient transfection of these into Jurkat or HeLa cells followed by initiation of apoptosis allowed us to map the potential caspase 6 cleavage site VEMD to the N terminal third of SATB 1 , leaving an intact DNA binding domain in the C terminal part of the protein . ^^^ |
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| Interacting proteins: Q01826 and P55212 |
Pubmed |
SVM Score :0.0 |
| SATB 1 cleavage by caspase 6 disrupts PDZ domain mediated dimerization , causing detachment from chromatin early in T cell apoptosis . ^^^ Here we show that SATB 1 is specifically cleaved by a caspase 6 like protease at amino acid position 254 to produce a 65 kDa major fragment containing both a base unpairing region ( BUR ) binding domain and a homeodomain . ^^^ |
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