| Interaction and functional cooperation of the cancer amplified transcriptional coactivator activating signal cointegrator 2 and E2F 1 in cell proliferation . ^^^ Here , we show that the expression pattern of ASC 2 was correlated with that of E2F 1 for protein increases at G ( 1 ) and S phase . ^^^ These results prompted us to examine the functional interaction of ASC 2 and E2F 1 . ^^^ Biochemical evidence of protein interaction indicated that the transactivation domain of E2F 1 interacted with the COOH terminal region of ASC 2 . ^^^ The importance of the E2F 1 ASC 2 interaction was supported by the demonstration that the coexpression of ASC 2 and E2F 1 synergistically transactivated E2F 1 driven gene transcription and the acetylation of E2F 1 protein was necessary for ASC 2 mediated transcriptional coactivation . ^^^ |