| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.52347667 |
| We now show that 14 3 3 tau , a phosphoserine binding protein , mediates E2F1 stabilization . 14 3 3 tau interacts with ATM phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination . 0.52347667^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| We document here up regulation of E2F1 , but not other members of the E2F gene family , in 15 of 18 primary papillary thyroid cancers examined ( 83 % ) in comparison to corresponding noncancerous thyroid tissues and in all of 11 anaplastic thyroid cancer ( ATC ) cell lines ( 100 % ) . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Our prior studies demonstrated selective induction and stabilization of E2F1 through ATM dependent phosphorylation in response to DNA damage . ^^^ This interaction was induced by DNA damage and phosphorylation of E2F1 by ATM . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| E2F1 / DP1 , however , can mediate p 53 dependent apoptosis in the absence of ARF through the upregulation of the p 53 kinase ATM and by E2F1directly binding to p 53 , which enhances p 53 transcriptional activity . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm / Nbs1 / Chk2 . ^^^ E2F1 and E 7 mediated apoptosis are compromised in cells from patients with the related disorders ataxia telangiectasia and Nijmegen breakage syndrome lacking functional Atm and Nbs 1 gene products , respectively . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| E2F1 uses the ATM signaling pathway to induce p 53 and Chk 2 phosphorylation and apoptosis . ^^^ Here , we describe a novel connection between E2F1 and the ATM DNA damage response pathway . ^^^ In primary human fibroblasts lacking functional ATM , the ability of E2F1 to induce the phosphorylation of p 53 and apoptosis is impaired . ^^^ In contrast , ATM status has no effect on transcriptional activation of target genes or the stimulation of DNA synthesis by E2F1 . ^^^ Moreover , E2F1 induces ATM and NBS 1 dependent phosphorylation of the checkpoint kinase Chk 2 at Thr 68 , a phosphorylation site that stimulates Chk 2 activity . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Selective induction of E2F1 in response to DNA damage , mediated by ATM dependent phosphorylation . ^^^ We now show that DNA damage leads to a specific induction of E2F1 accumulation , dependent on ATM kinase activity and that the specificity of E2F1 induction reflects a specificity in the phosphorylation of E2F1 by ATM as well as the related kinase ATR . ^^^ We identify a site for ATM / ATR phosphorylation in the amino terminus of E2F1 and we show that this site is required for ATM mediated stabilization of E2F1 . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| ATM is a target for positive regulation by E2F 1 . ^^^ We show here that E2F 1 elevates ATM promoter activity and induces an increase in ATM mRNA and protein levels . ^^^ These data demonstrate that ATM is transcriptionally regulated by E2F 1 and suggest that ATM serves as a novel , ARF independent functional link between the RB / E2F pathway and p53 . . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Recently , we described the requirement for the DNA damage response proteins Atm , Nbs 1 , and Chk 2 in the E2F1 apoptosis pathway . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| We previously showed that T oligos act through ATM , p95 / Nbs1 , E2F1 , p16INK4A , p 53 , and the p 53 homologue p 73 to modulate downstream effectors and now additionally demonstrate striking down regulation of the inhibitor of apoptosis protein livin / ML IAP . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| First , ATM and Chk 2 phosphorylate common substrates including p 53 , E2F1 , BRCA 1 , and Chk 2 itself , which suggests that Chk 2 ( also known as CHECK 2 , Cds 1 in fission yeast , and Dmchk 2 or Dmnk or Loki in the fruit fly ) acts as a relay for ATM and / or as a salvage pathway when ATM is inactivated . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Deregulation of the Rb / E2F pathway in human fibroblasts results in an E2F1 mediated apoptosis dependent on Atm , Nbs 1 , Chk 2 and p 53 . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| Oncogenes and the DNA damage response : Myc and E2F1 engage the ATM signaling pathway to activate p 53 and induce apoptosis . ^^^ Deregulated expression of the E2F1 transcription factor also elicits an ATM dependent checkpoint response that activates p 53 and promotes apoptosis , although the mechanism by which E2F1 and Myc stimulate ATM may differ . ^^^ |
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| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13315 and Q01094 |
Pubmed |
SVM Score :0.0 |
| NA |
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