| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| Analyses of over 400 genes in a mouse system transgenic for the E2F1 gene have identified several new downstream targets of E2F1 , including Brca 1 and Cdk 7 , in addition to several unidentified genes that are upregulated in the transgenic mice . ^^^ |
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| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| The Brca 1 gene is identified as an in vivo target of E2F1 in a transgenic mouse model . ^^^ The Brca 1 promoter contains E2F DNA binding sites that mediate transcriptional activation by E2F1 and repression by Rb . ^^^ The human BRCA 1 promoter also contains a conserved E2F site and is similarly regulated by E2F1 and Rb . ^^^ |
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| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| Furthermore , TopBP 1 relocalized E2F1 from diffuse nuclear distribution to discrete punctate nuclear foci , where E2F1 colocalized with TopBP 1 and BRCA 1 . ^^^ Thus , the specific interaction between TopBP 1 and E2F1 during DNA damage inhibits the known E2F1 activities but recruits E2F1 to a BRCA 1 containing repair complex , suggesting a direct role of E2F1 in DNA damage checkpoint / repair at stalled replication forks . . ^^^ |
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| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the E2F1 transcription factor in K 5 Cre : Brca 1 conditional knockout mice dramatically accelerated tumor development . ^^^ In addition , Brca 1 heterozygous female mice that had elevated E2F1 expression developed tumors of the reproductive tract at high incidence . ^^^ Moreover , inactivation of Brca 1 is shown to cooperate with deregulation of the Rb E2F1 pathway to promote tumorigenesis . . ^^^ |
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| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Recently , several transcription factors were found to possess large scale chromatin unfolding activity ; these include the VP 16 acidic activation domain , BRCA 1 , E2F1 , p 53 , and the glucocorticoid and estrogen steroid receptors . ^^^ |
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| Interacting proteins: Q01094 and P38398 |
Pubmed |
SVM Score :0.0 |
| First , ATM and Chk 2 phosphorylate common substrates including p 53 , E2F1 , BRCA 1 , and Chk 2 itself , which suggests that Chk 2 ( also known as CHECK 2 , Cds 1 in fission yeast , and Dmchk 2 or Dmnk or Loki in the fruit fly ) acts as a relay for ATM and / or as a salvage pathway when ATM is inactivated . ^^^ Functionally , Chk 2 can activate both apoptosis ( via p 53 , E2F1 and PML ) and cell cycle checkpoint ( via Cdc25A and Cdc25C , p 53 , and BRCA 1 ) . ^^^ |
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